STRINGSTRING
tgfbr2 tgfbr2 ARF6 ARF6 LOC103354964 LOC103354964 ATP5F1A ATP5F1A plcg1 plcg1 ENSSPAP00000001400 ENSSPAP00000001400 LOC103372209 LOC103372209 GATA2 GATA2 igf2 igf2 rreb1 rreb1 glipr2 glipr2 itgb1bp1 itgb1bp1 mtor mtor LOC103360542 LOC103360542 gpi gpi TGFBR2 TGFBR2 LOC103358913 LOC103358913 LOC103355037 LOC103355037 LOC103366454 LOC103366454 LOC103360654 LOC103360654 sirt1 sirt1 LOC103374663 LOC103374663 LOC103370644 LOC103370644 LOC103374198 LOC103374198 LOC103359516 LOC103359516 LOC103365633 LOC103365633 met met nfe2l2 nfe2l2 pik3cg pik3cg LOC103354591 LOC103354591 LOC103375280 LOC103375280 ENSSPAP00000014533 ENSSPAP00000014533 aamp aamp LOC103363938 LOC103363938 agt agt fgf2 fgf2 plcg2 plcg2 LOC103362358 LOC103362358 LOC103369128 LOC103369128 fgf1 fgf1 zc3h12a zc3h12a LOC103359141 LOC103359141 fgf16 fgf16 LOC103358541 LOC103358541 LOC103374289 LOC103374289 ctsh ctsh ENSSPAP00000019452 ENSSPAP00000019452 LOC103357988 LOC103357988 cib1 cib1 RIN2 RIN2 LOC103376433 LOC103376433 nrp1 nrp1 tgfb2 tgfb2 lgmn lgmn capn7 capn7 LOC103359300 LOC103359300 tsta3 tsta3 ENSSPAP00000023532 ENSSPAP00000023532 LOC103363690 LOC103363690 pdgfb pdgfb LOC103371395 LOC103371395 bsg bsg LOC103364206 LOC103364206 fgf7 fgf7 LOC103360420 LOC103360420 LOC103374411 LOC103374411 mst1r mst1r LOC103362006 LOC103362006 vegfa vegfa bmpr2 bmpr2 LOC103373263 LOC103373263 sp1 sp1 LOC103370974 LOC103370974 LOC103359878 LOC103359878 LOC103365994 LOC103365994 ENSSPAP00000031321 ENSSPAP00000031321 sash1 sash1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (583 aa)
ARF6ADP ribosylation factor 6. (123 aa)
LOC103354964Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (237 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (551 aa)
plcg11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1313 aa)
ENSSPAP00000001400Uncharacterized protein. (1302 aa)
LOC103372209Ras and Rab interactor 2. (1110 aa)
GATA2GATA binding protein 2. (455 aa)
igf2Insulin-like growth factor 2b. (215 aa)
rreb1Ras responsive element binding protein 1a. (1730 aa)
glipr2GLI pathogenesis-related 2, like; Belongs to the CRISP family. (156 aa)
itgb1bp1Integrin beta 1 binding protein 1. (198 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2514 aa)
LOC103360542ADAM metallopeptidase domain 17a. (876 aa)
gpiGlucose-6-phosphate isomerase; Belongs to the GPI family. (553 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (542 aa)
LOC1033589131-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1312 aa)
LOC103355037ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (518 aa)
LOC103366454acidPPc domain-containing protein. (313 aa)
LOC103360654SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (204 aa)
sirt1Deacetylase sirtuin-type domain-containing protein. (695 aa)
LOC103374663TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (587 aa)
LOC103370644CD40 molecule, TNF receptor superfamily member 5. (300 aa)
LOC103374198Transforming growth factor beta; Belongs to the TGF-beta family. (422 aa)
LOC103359516BCAS3 microtubule associated cell migration factor. (711 aa)
LOC103365633Phospholipid phosphatase 3. (307 aa)
metMET proto-oncogene, receptor tyrosine kinase. (1417 aa)
nfe2l2Nuclear factor, erythroid 2-like 2a. (613 aa)
pik3cgPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1123 aa)
LOC103354591ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (517 aa)
LOC103375280Transforming growth factor beta; Belongs to the TGF-beta family. (333 aa)
ENSSPAP00000014533Uncharacterized protein. (111 aa)
aampAngio-associated, migratory cell protein. (418 aa)
LOC103363938Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
agtAngiotensinogen; Belongs to the serpin family. (463 aa)
fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
plcg2Phosphoinositide phospholipase C. (1088 aa)
LOC103362358RAB25, member RAS oncogene family b. (208 aa)
LOC103369128Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1005 aa)
fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (181 aa)
zc3h12aZinc finger CCCH-type containing 12A. (621 aa)
LOC103359141Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (149 aa)
fgf16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
LOC103358541Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (520 aa)
LOC103374289Uncharacterized protein; Belongs to the peptidase C1 family. (336 aa)
ctshCathepsin H; Belongs to the peptidase C1 family. (323 aa)
ENSSPAP00000019452Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (282 aa)
LOC103357988ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (551 aa)
cib1Calcium and integrin binding 1 (calmyrin). (189 aa)
RIN2Ras and Rab interactor 2. (962 aa)
LOC103376433RAB25, member RAS oncogene family a. (211 aa)
nrp1Neuropilin; Belongs to the neuropilin family. (917 aa)
tgfb2Transforming growth factor, beta 2. (144 aa)
lgmnLegumain. (436 aa)
capn7Calpain 7; Belongs to the peptidase C2 family. (819 aa)
LOC103359300Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
tsta3Tissue specific transplantation antigen P35B. (326 aa)
ENSSPAP00000023532Macrophage stimulating 1 receptor b. (259 aa)
LOC103363690Heat shock protein, alpha-crystallin-related, 1; Belongs to the small heat shock protein (HSP20) family. (202 aa)
pdgfbPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (569 aa)
LOC103371395ADAM metallopeptidase domain 17b. (836 aa)
bsgBasigin. (273 aa)
LOC103364206SAM and SH3 domain containing 1b. (950 aa)
fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (202 aa)
LOC103360420Macrophage stimulating 1 receptor a. (1375 aa)
LOC103374411Si:dkey-206d17.12. (601 aa)
mst1rMacrophage stimulating 1 receptor b. (1369 aa)
LOC103362006Si:rp71-17i16.5; Belongs to the PI3/PI4-kinase family. (1081 aa)
vegfaVascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (212 aa)
bmpr2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1067 aa)
LOC103373263Transforming growth factor beta; Belongs to the TGF-beta family. (384 aa)
sp1Sp1 transcription factor. (710 aa)
LOC103370974JunE proto-oncogene, AP-1 transcription factor subunit. (340 aa)
LOC103359878GATA binding protein 2a. (459 aa)
LOC103365994Glucose-6-phosphate isomerase; Belongs to the GPI family. (502 aa)
ENSSPAP00000031321Vascular endothelial growth factor c; Belongs to the PDGF/VEGF growth factor family. (305 aa)
sash1SAM and SH3 domain containing 1a. (1227 aa)
Your Current Organism:
Stegastes partitus
NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish
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