(49 nodes) Regulation of epithelial to mesenchymal transition network (Stegastes partitus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	tgfb2	Transforming growth factor, beta 2. (144 aa)
	trim62	Tripartite motif containing 62, tandem duplicate 1. (475 aa)
	spry2	Sprouty RTK signaling antagonist 2. (353 aa)
	LOC103354549	Pleckstrin homology-like domain, family B, member 2b. (1161 aa)
	LOC103374198	Transforming growth factor beta; Belongs to the TGF-beta family. (422 aa)
	phldb1	Pleckstrin homology-like domain, family B, member 1b. (1482 aa)
	LOC103358766	Ephrin-A1a; Belongs to the ephrin family. (227 aa)
	ENSSPAP00000000280	Uncharacterized protein. (394 aa)
	ENSSPAP00000000292	PH domain-containing protein. (101 aa)
	tgfbr2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (583 aa)
	LOC103374507	Mothers against decapentaplegic homolog. (472 aa)
	LOC103361279	Lymphoid enhancer-binding factor 1. (364 aa)
	SMAD4	Mothers against decapentaplegic homolog. (528 aa)
	glipr2	GLI pathogenesis-related 2, like; Belongs to the CRISP family. (156 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2514 aa)
	LOC103354448	Peptidase S72 domain-containing protein. (910 aa)
	LOC103358884	Mothers against decapentaplegic homolog. (651 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (542 aa)
	LOC103361651	Mothers against decapentaplegic homolog. (503 aa)
	pofut2	Protein O-fucosyltransferase 2. (445 aa)
	llgl2	LLGL scribble cell polarity complex component 2. (1004 aa)
	LOC103372263	Eph receptor A4b. (968 aa)
	LOC103362262	C2H2-type domain-containing protein. (597 aa)
	tgfb3	Transforming growth factor beta; Belongs to the TGF-beta family. (405 aa)
	LOC103375280	Transforming growth factor beta; Belongs to the TGF-beta family. (333 aa)
	LOC103363473	Regulator of cell cycle. (126 aa)
	znf750	Zinc finger protein 750. (619 aa)
	mcrip1	MAPK regulated corepressor interacting protein 1. (98 aa)
	LOC103364526	Bone morphogenetic protein 16. (476 aa)
	LOC103362339	Interleukin-1. (247 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	alx1	ALX homeobox 1. (315 aa)
	LOC103373135	Peptidase S72 domain-containing protein. (881 aa)
	LOC103363570	Transforming growth factor beta; Belongs to the TGF-beta family. (408 aa)
	usf3	Upstream transcription factor family member 3. (2152 aa)
	ENSSPAP00000021125	PH domain-containing protein. (101 aa)
	LOC103359647	Pleckstrin homology-like domain, family B, member 1a. (1256 aa)
	hpn	Hepsin; Belongs to the peptidase S1 family. (425 aa)
	ENSSPAP00000023731	Homeobox domain-containing protein. (234 aa)
	spred3	Sprouty related EVH1 domain containing 3. (525 aa)
	GREM1	Gremlin; Belongs to the DAN family. (172 aa)
	bmp4	Bone morphogenetic protein 4. (403 aa)
	LOC103371952	Uncharacterized protein. (341 aa)
	bambi	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (258 aa)
	efna1	Ephrin-A1b; Belongs to the ephrin family. (234 aa)
	dab2	DAB adaptor protein 2. (787 aa)
	LOC103373263	Transforming growth factor beta; Belongs to the TGF-beta family. (384 aa)
	ENSSPAP00000030375	Uncharacterized protein. (293 aa)
	LOC103371033	Dystroglycan 1. (891 aa)

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSPAP00000000280	ENSSPAP00000000292	ENSSPAP00000000280	ENSSPAP00000000292	Uncharacterized protein.	PH domain-containing protein.	0.892
ENSSPAP00000000280	ENSSPAP00000021125	ENSSPAP00000000280	ENSSPAP00000021125	Uncharacterized protein.	PH domain-containing protein.	0.883
ENSSPAP00000000292	ENSSPAP00000000280	ENSSPAP00000000292	ENSSPAP00000000280	PH domain-containing protein.	Uncharacterized protein.	0.892
ENSSPAP00000000292	LOC103354549	ENSSPAP00000000292	ENSSPAP00000010224	PH domain-containing protein.	Pleckstrin homology-like domain, family B, member 2b.	0.899
ENSSPAP00000000292	LOC103359647	ENSSPAP00000000292	ENSSPAP00000021162	PH domain-containing protein.	Pleckstrin homology-like domain, family B, member 1a.	0.843
ENSSPAP00000021125	ENSSPAP00000000280	ENSSPAP00000021125	ENSSPAP00000000280	PH domain-containing protein.	Uncharacterized protein.	0.883
ENSSPAP00000021125	LOC103354549	ENSSPAP00000021125	ENSSPAP00000010224	PH domain-containing protein.	Pleckstrin homology-like domain, family B, member 2b.	0.882
ENSSPAP00000021125	LOC103359647	ENSSPAP00000021125	ENSSPAP00000021162	PH domain-containing protein.	Pleckstrin homology-like domain, family B, member 1a.	0.859
GREM1	LOC103363570	ENSSPAP00000026047	ENSSPAP00000019283	Gremlin; Belongs to the DAN family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.481
GREM1	LOC103364526	ENSSPAP00000026047	ENSSPAP00000014913	Gremlin; Belongs to the DAN family.	Bone morphogenetic protein 16.	0.857
GREM1	LOC103373263	ENSSPAP00000026047	ENSSPAP00000030243	Gremlin; Belongs to the DAN family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.503
GREM1	LOC103374198	ENSSPAP00000026047	ENSSPAP00000009403	Gremlin; Belongs to the DAN family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.498
GREM1	LOC103375280	ENSSPAP00000026047	ENSSPAP00000013200	Gremlin; Belongs to the DAN family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.498
GREM1	bmp4	ENSSPAP00000026047	ENSSPAP00000026584	Gremlin; Belongs to the DAN family.	Bone morphogenetic protein 4.	0.858
GREM1	tgfb2	ENSSPAP00000026047	ENSSPAP00000021337	Gremlin; Belongs to the DAN family.	Transforming growth factor, beta 2.	0.498
GREM1	tgfb3	ENSSPAP00000026047	ENSSPAP00000012361	Gremlin; Belongs to the DAN family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.481
LOC103354448	LOC103371033	ENSSPAP00000003995	ENSSPAP00000031011	Peptidase S72 domain-containing protein.	Dystroglycan 1.	0.933
LOC103354549	ENSSPAP00000000292	ENSSPAP00000010224	ENSSPAP00000000292	Pleckstrin homology-like domain, family B, member 2b.	PH domain-containing protein.	0.899
LOC103354549	ENSSPAP00000021125	ENSSPAP00000010224	ENSSPAP00000021125	Pleckstrin homology-like domain, family B, member 2b.	PH domain-containing protein.	0.882
LOC103358766	LOC103372263	ENSSPAP00000000027	ENSSPAP00000008919	Ephrin-A1a; Belongs to the ephrin family.	Eph receptor A4b.	0.801