(8 nodes) 5-flap endonuclease activity network (Stegastes partitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSSPAP00000004481	Uncharacterized protein. (226 aa)
	fen1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (381 aa)
	LOC103356596	Zgc:110269. (347 aa)
	LOC103361641	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (261 aa)
	ENSSPAP00000004515	Chromo_2 domain-containing protein. (692 aa)
	exo1	Exonuclease 1. (784 aa)
	dna2	DNA replication helicase/nuclease 2. (1044 aa)
	fan1	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (997 aa)

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSPAP00000004481	ENSSPAP00000004515	ENSSPAP00000004481	ENSSPAP00000004515	Uncharacterized protein.	Chromo_2 domain-containing protein.	0.900
ENSSPAP00000004481	LOC103356596	ENSSPAP00000004481	ENSSPAP00000002183	Uncharacterized protein.	Zgc:110269.	0.728
ENSSPAP00000004481	LOC103361641	ENSSPAP00000004481	ENSSPAP00000005292	Uncharacterized protein.	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	0.604
ENSSPAP00000004481	dna2	ENSSPAP00000004481	ENSSPAP00000017314	Uncharacterized protein.	DNA replication helicase/nuclease 2.	0.885
ENSSPAP00000004481	exo1	ENSSPAP00000004481	ENSSPAP00000022016	Uncharacterized protein.	Exonuclease 1.	0.700
ENSSPAP00000004481	fen1	ENSSPAP00000004481	ENSSPAP00000011428	Uncharacterized protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.728
ENSSPAP00000004515	ENSSPAP00000004481	ENSSPAP00000004515	ENSSPAP00000004481	Chromo_2 domain-containing protein.	Uncharacterized protein.	0.900
ENSSPAP00000004515	LOC103356596	ENSSPAP00000004515	ENSSPAP00000002183	Chromo_2 domain-containing protein.	Zgc:110269.	0.728
ENSSPAP00000004515	LOC103361641	ENSSPAP00000004515	ENSSPAP00000005292	Chromo_2 domain-containing protein.	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	0.604
ENSSPAP00000004515	dna2	ENSSPAP00000004515	ENSSPAP00000017314	Chromo_2 domain-containing protein.	DNA replication helicase/nuclease 2.	0.885
ENSSPAP00000004515	exo1	ENSSPAP00000004515	ENSSPAP00000022016	Chromo_2 domain-containing protein.	Exonuclease 1.	0.700
ENSSPAP00000004515	fen1	ENSSPAP00000004515	ENSSPAP00000011428	Chromo_2 domain-containing protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.728
LOC103356596	ENSSPAP00000004481	ENSSPAP00000002183	ENSSPAP00000004481	Zgc:110269.	Uncharacterized protein.	0.728
LOC103356596	ENSSPAP00000004515	ENSSPAP00000002183	ENSSPAP00000004515	Zgc:110269.	Chromo_2 domain-containing protein.	0.728
LOC103356596	LOC103361641	ENSSPAP00000002183	ENSSPAP00000005292	Zgc:110269.	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	0.681
LOC103356596	dna2	ENSSPAP00000002183	ENSSPAP00000017314	Zgc:110269.	DNA replication helicase/nuclease 2.	0.973
LOC103356596	exo1	ENSSPAP00000002183	ENSSPAP00000022016	Zgc:110269.	Exonuclease 1.	0.896
LOC103356596	fen1	ENSSPAP00000002183	ENSSPAP00000011428	Zgc:110269.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.904
LOC103361641	ENSSPAP00000004481	ENSSPAP00000005292	ENSSPAP00000004481	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	Uncharacterized protein.	0.604
LOC103361641	ENSSPAP00000004515	ENSSPAP00000005292	ENSSPAP00000004515	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	Chromo_2 domain-containing protein.	0.604