(52 nodes) Nerve development network (Stegastes partitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103368266	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (1156 aa)
	ednra	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (451 aa)
	serpine2	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; Belongs to the serpin family. (397 aa)
	LOC103362802	Nerve growth factor a (beta polypeptide); Belongs to the NGF-beta family. (252 aa)
	LOC103354479	Uncharacterized protein. (452 aa)
	LOC103360578	SIX homeobox 7. (260 aa)
	LOC103356146	F-box protein 45. (289 aa)
	rest	RE1-silencing transcription factor. (962 aa)
	ILK	Integrin linked kinase. (454 aa)
	ackr3	Atypical chemokine receptor 3a; Belongs to the G-protein coupled receptor 1 family. (377 aa)
	slitrk6	SLIT and NTRK-like family, member 6. (845 aa)
	LOC103367784	T-box transcription factor 5a. (525 aa)
	dlx3	Distal-less homeobox 3b. (280 aa)
	LOC103373543	Neurogenin 1. (194 aa)
	ENSSPAP00000012851	Uncharacterized protein. (127 aa)
	ENSSPAP00000013869	Chondrolectin. (237 aa)
	phox2b	Paired like homeobox 2Bb. (285 aa)
	LOC103373591	Uncharacterized protein. (646 aa)
	ENSSPAP00000016973	Adhesion G protein-coupled receptor G4b; Belongs to the G-protein coupled receptor 2 family. (431 aa)
	LOC103362723	Ring finger protein 165b. (349 aa)
	kifbp	Kif1 binding protein. (637 aa)
	six6	SIX homeobox 6a. (245 aa)
	LOC103357368	Neuropilin; Belongs to the neuropilin family. (846 aa)
	ENSSPAP00000017677	Nerve growth factor receptor a (TNFR superfamily, member 16). (289 aa)
	LOC103373135	Peptidase S72 domain-containing protein. (881 aa)
	LOC103362426	Endothelin receptor type Ab. (313 aa)
	LOC103353066	Neurturin. (242 aa)
	LOC103353638	Fibroblast growth factor receptor. (833 aa)
	nes	IF rod domain-containing protein; Belongs to the intermediate filament family. (1284 aa)
	vax1	Ventral anterior homeobox 1. (317 aa)
	six3	SIX homeobox 3a. (294 aa)
	vax2	Ventral anterior homeobox 2. (306 aa)
	LOC103368088	Neuropilin; Belongs to the neuropilin family. (932 aa)
	LOC103370415	SIX homeobox 3b. (277 aa)
	mib1	Mindbomb E3 ubiquitin protein ligase 1. (1020 aa)
	dlx5	Distal-less homeobox 5a. (285 aa)
	LOC103360486	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa; Belongs to the semaphorin family. (790 aa)
	phox2a	Paired like homeobox 2A. (301 aa)
	ENSSPAP00000028771	Transmembrane protein 126A. (198 aa)
	sulf1	Extracellular sulfatase. (869 aa)
	egr2	Early growth response 2b. (443 aa)
	ENSSPAP00000000944	G_PROTEIN_RECEP_F1_2 domain-containing protein. (349 aa)
	sulf2	Extracellular sulfatase. (875 aa)
	ENSSPAP00000002700	Nerve growth factor b (beta polypeptide); Belongs to the NGF-beta family. (124 aa)
	LOC103375125	F-box protein 45. (290 aa)
	LOC103371090	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fb; Belongs to the semaphorin family. (805 aa)
	ret	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1074 aa)
	adgrg6	Adhesion G protein-coupled receptor G6; Belongs to the G-protein coupled receptor 2 family. (1247 aa)
	LOC103371033	Dystroglycan 1. (891 aa)
	ENSSPAP00000003300	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (208 aa)
	LOC103354448	Peptidase S72 domain-containing protein. (910 aa)
	lrig1	Leucine-rich repeats and immunoglobulin-like domains 1. (1049 aa)

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSPAP00000000944	ENSSPAP00000012851	ENSSPAP00000000944	ENSSPAP00000012851	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Uncharacterized protein.	0.501
ENSSPAP00000002700	ENSSPAP00000003300	ENSSPAP00000002700	ENSSPAP00000003300	Nerve growth factor b (beta polypeptide); Belongs to the NGF-beta family.	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	0.407
ENSSPAP00000002700	ENSSPAP00000017677	ENSSPAP00000002700	ENSSPAP00000017677	Nerve growth factor b (beta polypeptide); Belongs to the NGF-beta family.	Nerve growth factor receptor a (TNFR superfamily, member 16).	0.988
ENSSPAP00000002700	LOC103353066	ENSSPAP00000002700	ENSSPAP00000018963	Nerve growth factor b (beta polypeptide); Belongs to the NGF-beta family.	Neurturin.	0.491
ENSSPAP00000002700	LOC103353638	ENSSPAP00000002700	ENSSPAP00000020376	Nerve growth factor b (beta polypeptide); Belongs to the NGF-beta family.	Fibroblast growth factor receptor.	0.829
ENSSPAP00000002700	LOC103362802	ENSSPAP00000002700	ENSSPAP00000005273	Nerve growth factor b (beta polypeptide); Belongs to the NGF-beta family.	Nerve growth factor a (beta polypeptide); Belongs to the NGF-beta family.	0.830
ENSSPAP00000002700	ret	ENSSPAP00000002700	ENSSPAP00000000498	Nerve growth factor b (beta polypeptide); Belongs to the NGF-beta family.	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.	0.664
ENSSPAP00000003300	ENSSPAP00000002700	ENSSPAP00000003300	ENSSPAP00000002700	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	Nerve growth factor b (beta polypeptide); Belongs to the NGF-beta family.	0.407
ENSSPAP00000003300	ENSSPAP00000017677	ENSSPAP00000003300	ENSSPAP00000017677	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	Nerve growth factor receptor a (TNFR superfamily, member 16).	0.990
ENSSPAP00000003300	LOC103353638	ENSSPAP00000003300	ENSSPAP00000020376	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	Fibroblast growth factor receptor.	0.837
ENSSPAP00000003300	LOC103362802	ENSSPAP00000003300	ENSSPAP00000005273	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	Nerve growth factor a (beta polypeptide); Belongs to the NGF-beta family.	0.421
ENSSPAP00000003300	ret	ENSSPAP00000003300	ENSSPAP00000000498	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.	0.679
ENSSPAP00000012851	ENSSPAP00000000944	ENSSPAP00000012851	ENSSPAP00000000944	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.501
ENSSPAP00000012851	LOC103362426	ENSSPAP00000012851	ENSSPAP00000018883	Uncharacterized protein.	Endothelin receptor type Ab.	0.992
ENSSPAP00000012851	ackr3	ENSSPAP00000012851	ENSSPAP00000009648	Uncharacterized protein.	Atypical chemokine receptor 3a; Belongs to the G-protein coupled receptor 1 family.	0.501
ENSSPAP00000012851	dlx5	ENSSPAP00000012851	ENSSPAP00000025865	Uncharacterized protein.	Distal-less homeobox 5a.	0.418
ENSSPAP00000012851	ednra	ENSSPAP00000012851	ENSSPAP00000004293	Uncharacterized protein.	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	0.993
ENSSPAP00000012851	nes	ENSSPAP00000012851	ENSSPAP00000021374	Uncharacterized protein.	IF rod domain-containing protein; Belongs to the intermediate filament family.	0.426
ENSSPAP00000012851	serpine2	ENSSPAP00000012851	ENSSPAP00000004751	Uncharacterized protein.	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; Belongs to the serpin family.	0.408
ENSSPAP00000017677	ENSSPAP00000002700	ENSSPAP00000017677	ENSSPAP00000002700	Nerve growth factor receptor a (TNFR superfamily, member 16).	Nerve growth factor b (beta polypeptide); Belongs to the NGF-beta family.	0.988