(71 nodes) Lung development network (Stegastes partitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rc3h2	Ring finger and CCCH-type domains 2. (1156 aa)
	hspb11	Zgc:158640. (130 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (542 aa)
	pkdcc	Protein kinase domain containing, cytoplasmic b. (499 aa)
	hhip	Hedgehog interacting protein. (698 aa)
	LOC103354448	Peptidase S72 domain-containing protein. (910 aa)
	ctsz	Cathepsin Z; Belongs to the peptidase C1 family. (303 aa)
	ENSSPAP00000001331	Uncharacterized protein. (887 aa)
	ENSSPAP00000001228	Uncharacterized protein. (546 aa)
	SP3	Sp3a transcription factor. (705 aa)
	LOC103354964	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (237 aa)
	tgfbr2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (583 aa)
	LOC103358784	Endothelin 2. (162 aa)
	LOC103371033	Dystroglycan 1. (891 aa)
	LOC103371563	E1A binding protein p300 a. (2869 aa)
	LOC103373263	Transforming growth factor beta; Belongs to the TGF-beta family. (384 aa)
	bmpr2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1067 aa)
	LOC103353791	Sp3b transcription factor. (655 aa)
	sav1	Salvador family WW domain containing protein 1. (420 aa)
	LOC103364251	Insulin-like growth factor binding protein 5a. (267 aa)
	stk40	Serine/threonine kinase 40. (436 aa)
	timeless	Timeless circadian clock. (1248 aa)
	zfpm2	Zinc finger protein, FOG family member 2a. (1149 aa)
	fgf7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (202 aa)
	slc7a11	Solute carrier family 7 member 11. (511 aa)
	ENSSPAP00000024939	Protein phosphatase 3 (formerly 2B), regulatory s1ubunit B, alpha isoform, b. (168 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (314 aa)
	ep300	E1A binding protein p300 b. (2872 aa)
	LOC103366994	Uncharacterized protein. (679 aa)
	SRF-2	Serum response factor. (478 aa)
	LOC103359300	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
	ENSSPAP00000021025	ADAM_spacer1 domain-containing protein. (165 aa)
	wnt2b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (390 aa)
	tcf21	Transcription factor 21. (173 aa)
	aimp2	Aminoacyl tRNA synthetase complex interacting multifunctional protein 2. (323 aa)
	ctsh	Cathepsin H; Belongs to the peptidase C1 family. (323 aa)
	aard	Uncharacterized protein. (109 aa)
	ENSSPAP00000018277	Polycystic kidney disease 1b. (3029 aa)
	ENSSPAP00000018240	Uncharacterized protein. (124 aa)
	LOC103374289	Uncharacterized protein; Belongs to the peptidase C1 family. (336 aa)
	LOC103370300	Si:ch211-267e7.3. (763 aa)
	LOC103373135	Peptidase S72 domain-containing protein. (881 aa)
	hps1	HPS1 biogenesis of lysosomal organelles complex 3 subunit 1. (682 aa)
	pkd1	Polycystic kidney disease 1a. (4558 aa)
	bag6	BCL2 associated athanogene 6. (1217 aa)
	LOC103359141	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (149 aa)
	LOC103374798	Uncharacterized protein. (170 aa)
	fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (181 aa)
	LOC103369128	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1005 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	LOC103363938	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	ENSSPAP00000014599	Uncharacterized protein. (245 aa)
	LOC103355759	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (300 aa)
	dlg5	Discs, large homolog 5a (Drosophila); Belongs to the MAGUK family. (2028 aa)
	LOC103353494	Si:ch73-352p4.8. (462 aa)
	LOC103372955	Integrin, alpha 3b; Belongs to the integrin alpha chain family. (1056 aa)
	LOC103374719	ADAMTS-like 2. (390 aa)
	ccn2	Cellular communication network factor 2a. (347 aa)
	spry2	Sprouty RTK signaling antagonist 2. (353 aa)
	errfi1	ERBB receptor feedback inhibitor 1a. (425 aa)
	LOC103371819	Insulin-like growth factor binding protein 5a. (264 aa)
	LOC103356172	Sphingomyelin phosphodiesterase 3, neutral. (516 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1081 aa)
	SRF	Serum response factor. (601 aa)
	phf14	Uncharacterized protein. (945 aa)
	LOC103357002	BCL2 associated athanogene 6, like. (1189 aa)
	atxn1l	Ataxin 1-like. (835 aa)
	phex	Phosphate regulating endopeptidase homolog, X-linked. (744 aa)
	itgb6	Integrin beta; Belongs to the integrin beta chain family. (783 aa)
	LOC103374062	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (342 aa)
	tab1	TGF-beta activated kinase 1/MAP3K7 binding protein 1. (497 aa)

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSPAP00000001228	ENSSPAP00000018240	ENSSPAP00000001228	ENSSPAP00000018240	Uncharacterized protein.	Uncharacterized protein.	0.814
ENSSPAP00000001228	LOC103354448	ENSSPAP00000001228	ENSSPAP00000003995	Uncharacterized protein.	Peptidase S72 domain-containing protein.	0.730
ENSSPAP00000001228	LOC103371033	ENSSPAP00000001228	ENSSPAP00000031011	Uncharacterized protein.	Dystroglycan 1.	0.730
ENSSPAP00000001228	LOC103372955	ENSSPAP00000001228	ENSSPAP00000010763	Uncharacterized protein.	Integrin, alpha 3b; Belongs to the integrin alpha chain family.	0.814
ENSSPAP00000001228	LOC103373135	ENSSPAP00000001228	ENSSPAP00000017723	Uncharacterized protein.	Peptidase S72 domain-containing protein.	0.729
ENSSPAP00000001228	itgb6	ENSSPAP00000001228	ENSSPAP00000006945	Uncharacterized protein.	Integrin beta; Belongs to the integrin beta chain family.	0.862
ENSSPAP00000001331	ENSSPAP00000018240	ENSSPAP00000001331	ENSSPAP00000018240	Uncharacterized protein.	Uncharacterized protein.	0.814
ENSSPAP00000001331	LOC103354448	ENSSPAP00000001331	ENSSPAP00000003995	Uncharacterized protein.	Peptidase S72 domain-containing protein.	0.730
ENSSPAP00000001331	LOC103371033	ENSSPAP00000001331	ENSSPAP00000031011	Uncharacterized protein.	Dystroglycan 1.	0.730
ENSSPAP00000001331	LOC103372955	ENSSPAP00000001331	ENSSPAP00000010763	Uncharacterized protein.	Integrin, alpha 3b; Belongs to the integrin alpha chain family.	0.814
ENSSPAP00000001331	LOC103373135	ENSSPAP00000001331	ENSSPAP00000017723	Uncharacterized protein.	Peptidase S72 domain-containing protein.	0.729
ENSSPAP00000001331	itgb6	ENSSPAP00000001331	ENSSPAP00000006945	Uncharacterized protein.	Integrin beta; Belongs to the integrin beta chain family.	0.862
ENSSPAP00000014599	LOC103354964	ENSSPAP00000014599	ENSSPAP00000000461	Uncharacterized protein.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.639
ENSSPAP00000014599	LOC103374289	ENSSPAP00000014599	ENSSPAP00000018014	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.639
ENSSPAP00000014599	ctsh	ENSSPAP00000014599	ENSSPAP00000018626	Uncharacterized protein.	Cathepsin H; Belongs to the peptidase C1 family.	0.639
ENSSPAP00000018240	ENSSPAP00000001228	ENSSPAP00000018240	ENSSPAP00000001228	Uncharacterized protein.	Uncharacterized protein.	0.814
ENSSPAP00000018240	ENSSPAP00000001331	ENSSPAP00000018240	ENSSPAP00000001331	Uncharacterized protein.	Uncharacterized protein.	0.814
ENSSPAP00000018240	LOC103373263	ENSSPAP00000018240	ENSSPAP00000030243	Uncharacterized protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.681
ENSSPAP00000018240	PTK7	ENSSPAP00000018240	ENSSPAP00000008528	Uncharacterized protein.	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.621
ENSSPAP00000018240	itgb6	ENSSPAP00000018240	ENSSPAP00000006945	Uncharacterized protein.	Integrin beta; Belongs to the integrin beta chain family.	0.920