(78 nodes) BMP signaling pathway network (Stegastes partitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rgma	Repulsive guidance molecule BMP co-receptor a. (450 aa)
	gdf15	TGF_BETA_2 domain-containing protein. (372 aa)
	LOC103361051	Programmed cell death 4a. (458 aa)
	ENSSPAP00000001621	TGF_BETA_2 domain-containing protein. (112 aa)
	LOC103374507	Mothers against decapentaplegic homolog. (472 aa)
	LOC103361279	Lymphoid enhancer-binding factor 1. (364 aa)
	SMAD4	Mothers against decapentaplegic homolog. (528 aa)
	znf831	Uncharacterized protein. (1755 aa)
	smad1	Mothers against decapentaplegic homolog. (467 aa)
	smad9	Mothers against decapentaplegic homolog. (469 aa)
	ccdc142	Uncharacterized protein. (1213 aa)
	LOC103358884	Mothers against decapentaplegic homolog. (651 aa)
	acvr1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (678 aa)
	LOC103361063	Mothers against decapentaplegic homolog. (467 aa)
	LOC103356680	CTCK domain-containing protein. (208 aa)
	LOC103361651	Mothers against decapentaplegic homolog. (503 aa)
	bmp10	Bone morphogenetic protein 10. (468 aa)
	LOC103361652	Bone morphogenetic protein 10, like. (459 aa)
	pdcd4	Programmed cell death 4b. (474 aa)
	LOC103353951	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (511 aa)
	smad7	Mothers against decapentaplegic homolog. (362 aa)
	TBX2	T-box transcription factor 2. (684 aa)
	LOC103356172	Sphingomyelin phosphodiesterase 3, neutral. (516 aa)
	LOC103369016	Muscle segment homeobox 3. (255 aa)
	LOC103374198	Transforming growth factor beta; Belongs to the TGF-beta family. (422 aa)
	LOC103371821	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
	LOC103363430	Spartin b. (604 aa)
	bmp6	Bone morphogenetic protein 6. (429 aa)
	acvr2b	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (563 aa)
	usp9x	Ubiquitin specific peptidase 9; Belongs to the peptidase C19 family. (2489 aa)
	tgfb3	Transforming growth factor beta; Belongs to the TGF-beta family. (405 aa)
	bmpr1b	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
	LOC103375280	Transforming growth factor beta; Belongs to the TGF-beta family. (333 aa)
	yap1	Yes-associated protein 1. (438 aa)
	smad2	Mothers against decapentaplegic homolog. (470 aa)
	LOC103363483	Mothers against decapentaplegic homolog. (476 aa)
	bmp5	Bone morphogenetic protein 5. (456 aa)
	LOC103360771	Ventral homeobox. (250 aa)
	bmpr2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1067 aa)
	bmpr1a	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (487 aa)
	bmper	BMP binding endothelial regulator. (726 aa)
	LOC103353199	Mothers against decapentaplegic homolog. (425 aa)
	LOC103353200	Mothers against decapentaplegic homolog. (503 aa)
	bmp4	Bone morphogenetic protein 4. (403 aa)
	inppl1	Inositol polyphosphate phosphatase-like 1a. (1262 aa)
	LOC103371952	Uncharacterized protein. (341 aa)
	bmp7	Bone morphogenetic protein 7a. (425 aa)
	hivep1	Human immunodeficiency virus type I enhancer binding protein 1. (2440 aa)
	rgmb	Repulsive guidance molecule BMP co-receptor b. (467 aa)
	LOC103364526	Bone morphogenetic protein 16. (476 aa)
	LOC103375337	Southpaw. (467 aa)
	bmp2	Bone morphogenetic protein 2b. (416 aa)
	fam83g	FAM83 domain-containing protein. (1535 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	LOC103374786	Lefty1. (351 aa)
	LOC103369128	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1005 aa)
	sostdc1	Sclerostin domain containing 1a. (250 aa)
	gdf3	Growth differentiation factor 3. (377 aa)
	LOC103359174	Family with sequence similarity 83 member G. (834 aa)
	LOC103363570	Transforming growth factor beta; Belongs to the TGF-beta family. (408 aa)
	msx1	Muscle segment homeobox 1a. (283 aa)
	ENSSPAP00000020948	TGF_BETA_2 domain-containing protein. (115 aa)
	LOC103364677	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
	tgfb2	Transforming growth factor, beta 2. (144 aa)
	LOC103356906	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
	fkbp8	Peptidylprolyl isomerase. (404 aa)
	bmp15	Bone morphogenetic protein 15. (452 aa)
	LOC103370385	T-box transcription factor 2a. (618 aa)
	slc33a1	Solute carrier family 33 member 1. (619 aa)
	TMEM100	Transmembrane protein 100. (172 aa)
	acvr2a	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (476 aa)
	LOC103363674	Hemojuvelin BMP co-receptor. (420 aa)
	LOC103374962	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (520 aa)
	LOC103371300	RGM domain family, member D. (434 aa)
	LOC103370837	Bone morphogenetic protein 7b. (427 aa)
	smad6	Mothers against decapentaplegic homolog. (488 aa)
	smad3	Mothers against decapentaplegic homolog. (425 aa)
	LOC103371424	Bone morphogenetic protein 8a. (415 aa)

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSPAP00000001621	ENSSPAP00000020948	ENSSPAP00000001621	ENSSPAP00000020948	TGF_BETA_2 domain-containing protein.	TGF_BETA_2 domain-containing protein.	0.823
ENSSPAP00000001621	LOC103353199	ENSSPAP00000001621	ENSSPAP00000025771	TGF_BETA_2 domain-containing protein.	Mothers against decapentaplegic homolog.	0.473
ENSSPAP00000001621	LOC103353200	ENSSPAP00000001621	ENSSPAP00000025788	TGF_BETA_2 domain-containing protein.	Mothers against decapentaplegic homolog.	0.434
ENSSPAP00000001621	LOC103353951	ENSSPAP00000001621	ENSSPAP00000007907	TGF_BETA_2 domain-containing protein.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.939
ENSSPAP00000001621	LOC103356906	ENSSPAP00000001621	ENSSPAP00000021340	TGF_BETA_2 domain-containing protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.675
ENSSPAP00000001621	LOC103358884	ENSSPAP00000001621	ENSSPAP00000005222	TGF_BETA_2 domain-containing protein.	Mothers against decapentaplegic homolog.	0.434
ENSSPAP00000001621	LOC103361063	ENSSPAP00000001621	ENSSPAP00000005664	TGF_BETA_2 domain-containing protein.	Mothers against decapentaplegic homolog.	0.473
ENSSPAP00000001621	LOC103361651	ENSSPAP00000001621	ENSSPAP00000005949	TGF_BETA_2 domain-containing protein.	Mothers against decapentaplegic homolog.	0.434
ENSSPAP00000001621	LOC103363483	ENSSPAP00000001621	ENSSPAP00000014003	TGF_BETA_2 domain-containing protein.	Mothers against decapentaplegic homolog.	0.447
ENSSPAP00000001621	LOC103364526	ENSSPAP00000001621	ENSSPAP00000014913	TGF_BETA_2 domain-containing protein.	Bone morphogenetic protein 16.	0.542
ENSSPAP00000001621	LOC103364677	ENSSPAP00000001621	ENSSPAP00000021041	TGF_BETA_2 domain-containing protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.675
ENSSPAP00000001621	LOC103369128	ENSSPAP00000001621	ENSSPAP00000016060	TGF_BETA_2 domain-containing protein.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.657
ENSSPAP00000001621	LOC103371821	ENSSPAP00000001621	ENSSPAP00000009916	TGF_BETA_2 domain-containing protein.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.939
ENSSPAP00000001621	LOC103374507	ENSSPAP00000001621	ENSSPAP00000001838	TGF_BETA_2 domain-containing protein.	Mothers against decapentaplegic homolog.	0.434
ENSSPAP00000001621	LOC103374786	ENSSPAP00000001621	ENSSPAP00000015693	TGF_BETA_2 domain-containing protein.	Lefty1.	0.934
ENSSPAP00000001621	LOC103374962	ENSSPAP00000001621	ENSSPAP00000023554	TGF_BETA_2 domain-containing protein.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.675
ENSSPAP00000001621	LOC103375337	ENSSPAP00000001621	ENSSPAP00000014935	TGF_BETA_2 domain-containing protein.	Southpaw.	0.898
ENSSPAP00000001621	SMAD4	ENSSPAP00000001621	ENSSPAP00000003348	TGF_BETA_2 domain-containing protein.	Mothers against decapentaplegic homolog.	0.434
ENSSPAP00000001621	acvr1	ENSSPAP00000001621	ENSSPAP00000005358	TGF_BETA_2 domain-containing protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.675
ENSSPAP00000001621	acvr2a	ENSSPAP00000001621	ENSSPAP00000030119	TGF_BETA_2 domain-containing protein.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.939