(56 nodes) Erythrocyte homeostasis network (Stegastes partitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103366884	Ion_trans domain-containing protein; Belongs to the potassium channel family. (500 aa)
	LOC103354132	Ribosomal protein S19. (146 aa)
	cdk5rap3	CDK5 regulatory subunit associated protein 3. (503 aa)
	LOC103360505	Phospholipase A(2). (153 aa)
	ercc2	Excision repair cross-complementation group 2. (760 aa)
	gpi	Glucose-6-phosphate isomerase; Belongs to the GPI family. (553 aa)
	ENSSPAP00000004906	Uncharacterized protein. (100 aa)
	hspa9	Heat shock protein 9; Belongs to the heat shock protein 70 family. (683 aa)
	LOC103365994	Glucose-6-phosphate isomerase; Belongs to the GPI family. (502 aa)
	acin1	SAP domain-containing protein. (1750 aa)
	ENSSPAP00000029839	CCAAT enhancer binding protein gamma. (147 aa)
	adar	Adenosine deaminase RNA specific. (1338 aa)
	LOC103359829	ATP synthase inhibitory factor subunit 1b. (107 aa)
	rps3	Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (245 aa)
	LOC103365900	GATA binding protein 1a. (425 aa)
	med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1827 aa)
	maea	Macrophage erythroblast attacher. (396 aa)
	LOC103353791	Sp3b transcription factor. (655 aa)
	zfpm1	Zinc finger protein, FOG family member 1. (1225 aa)
	melk	Non-specific serine/threonine protein kinase. (679 aa)
	rpl35	Ribosomal protein L35. (123 aa)
	tert	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1107 aa)
	LOC103371456	Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family. (397 aa)
	LOC103357506	5-aminolevulinate synthase. (623 aa)
	RPS19	Ribosomal protein S19. (152 aa)
	LOC103368781	5-aminolevulinate synthase. (602 aa)
	SRF-2	Serum response factor. (478 aa)
	rps15a	Ribosomal protein S15a; Belongs to the universal ribosomal protein uS8 family. (130 aa)
	slc25a38	Mitochondrial glycine transporter; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis. Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. (283 aa)
	ENSSPAP00000021526	BHLH domain-containing protein. (108 aa)
	hdac9	Histone deacetylase 9b. (625 aa)
	LOC103355903	Zgc:154061. (343 aa)
	LOC103365158	T-cell acute lymphocytic leukemia 1. (388 aa)
	bdh2	3-hydroxybutyrate dehydrogenase, type 2. (245 aa)
	rb1	Retinoblastoma 1. (909 aa)
	lmo2	LIM domain only 2 (rhombotin-like 1). (160 aa)
	LOC103364442	Mitochondrial glycine transporter; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis. Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. (286 aa)
	SRF	Serum response factor. (601 aa)
	trim33	Tripartite motif containing 33. (1204 aa)
	mfhas1	Malignant fibrous histiocytoma amplified sequence 1. (1038 aa)
	ism1	Isthmin 1. (455 aa)
	ENSSPAP00000011163	RRM domain-containing protein. (598 aa)
	ENSSPAP00000011175	SAP domain-containing protein. (72 aa)
	kcnq1	Potassium voltage-gated channel, KQT-like subfamily, member 1.1; Belongs to the potassium channel family. (630 aa)
	rpl27	60S ribosomal protein L27; Belongs to the eukaryotic ribosomal protein eL27 family. (136 aa)
	alas2	5-aminolevulinate synthase. (591 aa)
	kmt2e	Lysine (K)-specific methyltransferase 2E. (1212 aa)
	ENSSPAP00000015564	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (391 aa)
	ufl1	UFM1-specific ligase 1. (795 aa)
	sh2b3	SH2B adaptor protein 3. (749 aa)
	sfxn4	Sideroflexin 4. (325 aa)
	SP3	Sp3a transcription factor. (705 aa)
	epo	Erythropoietin; Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Belongs to the EPO/TPO family. (185 aa)
	slc40a1	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (573 aa)
	lyar	Ly1 antibody reactive homolog (mouse). (338 aa)
	uba5	Ubiquitin-like modifier activating enzyme 5. (403 aa)

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSPAP00000004906	ENSSPAP00000011163	ENSSPAP00000004906	ENSSPAP00000011163	Uncharacterized protein.	RRM domain-containing protein.	0.525
ENSSPAP00000004906	ENSSPAP00000011175	ENSSPAP00000004906	ENSSPAP00000011175	Uncharacterized protein.	SAP domain-containing protein.	0.525
ENSSPAP00000004906	acin1	ENSSPAP00000004906	ENSSPAP00000030681	Uncharacterized protein.	SAP domain-containing protein.	0.525
ENSSPAP00000004906	ercc2	ENSSPAP00000004906	ENSSPAP00000002762	Uncharacterized protein.	Excision repair cross-complementation group 2.	0.438
ENSSPAP00000004906	mfhas1	ENSSPAP00000004906	ENSSPAP00000010830	Uncharacterized protein.	Malignant fibrous histiocytoma amplified sequence 1.	0.408
ENSSPAP00000004906	rpl27	ENSSPAP00000004906	ENSSPAP00000013620	Uncharacterized protein.	60S ribosomal protein L27; Belongs to the eukaryotic ribosomal protein eL27 family.	0.445
ENSSPAP00000004906	rpl35	ENSSPAP00000004906	ENSSPAP00000027706	Uncharacterized protein.	Ribosomal protein L35.	0.509
ENSSPAP00000004906	rps15a	ENSSPAP00000004906	ENSSPAP00000022147	Uncharacterized protein.	Ribosomal protein S15a; Belongs to the universal ribosomal protein uS8 family.	0.517
ENSSPAP00000004906	rps3	ENSSPAP00000004906	ENSSPAP00000029604	Uncharacterized protein.	Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family.	0.546
ENSSPAP00000011163	ENSSPAP00000004906	ENSSPAP00000011163	ENSSPAP00000004906	RRM domain-containing protein.	Uncharacterized protein.	0.525
ENSSPAP00000011175	ENSSPAP00000004906	ENSSPAP00000011175	ENSSPAP00000004906	SAP domain-containing protein.	Uncharacterized protein.	0.525
ENSSPAP00000021526	LOC103365900	ENSSPAP00000021526	ENSSPAP00000028230	BHLH domain-containing protein.	GATA binding protein 1a.	0.907
ENSSPAP00000021526	lmo2	ENSSPAP00000021526	ENSSPAP00000018565	BHLH domain-containing protein.	LIM domain only 2 (rhombotin-like 1).	0.980
ENSSPAP00000021526	zfpm1	ENSSPAP00000021526	ENSSPAP00000027763	BHLH domain-containing protein.	Zinc finger protein, FOG family member 1.	0.490
ENSSPAP00000029839	melk	ENSSPAP00000029839	ENSSPAP00000027747	CCAAT enhancer binding protein gamma.	Non-specific serine/threonine protein kinase.	0.456
LOC103353791	LOC103365900	ENSSPAP00000028113	ENSSPAP00000028230	Sp3b transcription factor.	GATA binding protein 1a.	0.592
LOC103353791	med1	ENSSPAP00000028113	ENSSPAP00000028174	Sp3b transcription factor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.404
LOC103353791	trim33	ENSSPAP00000028113	ENSSPAP00000010443	Sp3b transcription factor.	Tripartite motif containing 33.	0.404
LOC103354132	LOC103366884	ENSSPAP00000017355	ENSSPAP00000016777	Ribosomal protein S19.	Ion_trans domain-containing protein; Belongs to the potassium channel family.	0.650
LOC103354132	RPS19	ENSSPAP00000017355	ENSSPAP00000027041	Ribosomal protein S19.	Ribosomal protein S19.	0.899