(15 nodes) Positive regulation of insulin secretion involved in cellular response to glucose stimulus network (Stegastes partitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	mpc2	Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (126 aa)
	ENSSPAP00000029940	annotation not available (118 aa)
	LOC103360989	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1155 aa)
	bad	BCL2 associated agonist of cell death b. (166 aa)
	pla2g6	Phospholipase A2, group VI (cytosolic, calcium-independent). (767 aa)
	c2cd2l	C2cd2 like. (692 aa)
	pdx1	Pancreatic and duodenal homeobox 1. (257 aa)
	nr1h4	Nuclear receptor subfamily 1, group H, member 4. (485 aa)
	LOC103354601	Grancalcin. (249 aa)
	ENSSPAP00000012050	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (323 aa)
	sri	Uncharacterized protein. (185 aa)
	ENSSPAP00000001250	Guanylate cyclase domain-containing protein. (118 aa)
	ENSSPAP00000011040	Nuclear receptor subfamily 1, group H, member 5. (378 aa)
	rfx6	Regulatory factor X, 6. (855 aa)
	adcy8	Adenylate cyclase 8 (brain); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (913 aa)

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSPAP00000001250	ENSSPAP00000012050	ENSSPAP00000001250	ENSSPAP00000012050	Guanylate cyclase domain-containing protein.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.947
ENSSPAP00000001250	adcy8	ENSSPAP00000001250	ENSSPAP00000005445	Guanylate cyclase domain-containing protein.	Adenylate cyclase 8 (brain); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.943
ENSSPAP00000012050	ENSSPAP00000001250	ENSSPAP00000012050	ENSSPAP00000001250	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein.	0.947
ENSSPAP00000012050	ENSSPAP00000029940	ENSSPAP00000012050	ENSSPAP00000029940	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	annotation not available	0.947
ENSSPAP00000029940	ENSSPAP00000012050	ENSSPAP00000029940	ENSSPAP00000012050	annotation not available	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.947
ENSSPAP00000029940	adcy8	ENSSPAP00000029940	ENSSPAP00000005445	annotation not available	Adenylate cyclase 8 (brain); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.943
adcy8	ENSSPAP00000001250	ENSSPAP00000005445	ENSSPAP00000001250	Adenylate cyclase 8 (brain); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein.	0.943
adcy8	ENSSPAP00000029940	ENSSPAP00000005445	ENSSPAP00000029940	Adenylate cyclase 8 (brain); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	annotation not available	0.943