(89 nodes) Positive regulation of I-kappaB kinase/NF-kappaB signaling network (Stegastes partitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	edar	Ectodysplasin A receptor. (477 aa)
	ddx1	DEAD (Asp-Glu-Ala-Asp) box helicase 1. (712 aa)
	ENSSPAP00000030603	Phorbol-ester/DAG-type domain-containing protein. (56 aa)
	abl1	Tyrosine-protein kinase. (1119 aa)
	card9	CARD domain-containing protein. (180 aa)
	lpar1	Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (353 aa)
	tab2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (758 aa)
	dhx36	DEAH (Asp-Glu-Ala-His) box polypeptide 36. (1066 aa)
	LOC103358764	EF-hand domain-containing protein. (87 aa)
	irak4	Interleukin-1 receptor-associated kinase 4. (489 aa)
	LOC103373233	SHANK-associated RH domain interacting protein. (323 aa)
	fadd	Uncharacterized protein. (191 aa)
	tab3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (627 aa)
	LOC103360204	S100 calcium binding protein, beta (neural). (96 aa)
	cflar	Uncharacterized protein; Belongs to the peptidase C14A family. (464 aa)
	LOC103376203	Caspase 10, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (549 aa)
	DHX15	DEAH-box helicase 15. (762 aa)
	trim32	Tripartite motif containing 32. (685 aa)
	LOC103373869	Si:dkey-181m9.8. (753 aa)
	ENSSPAP00000026845	SEFIR domain-containing protein. (125 aa)
	LOC103376168	SEFIR domain-containing protein. (437 aa)
	nod2	Nucleotide-binding oligomerization domain containing 2. (989 aa)
	nod1	Nucleotide-binding oligomerization domain containing 1. (910 aa)
	LOC103371620	Metadherin a. (507 aa)
	htr2b	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled. (473 aa)
	pink1	PTEN induced kinase 1. (572 aa)
	LOC103367027	Uncharacterized protein. (1421 aa)
	LOC103365293	Tumor necrosis factor receptor superfamily, member 1a. (336 aa)
	mul1	Mitochondrial E3 ubiquitin protein ligase 1b. (352 aa)
	LOC103362524	Protein S100; Belongs to the S-100 family. (87 aa)
	LOC103361464	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (654 aa)
	abl2	Tyrosine-protein kinase. (1203 aa)
	LOC103356949	TRAF3 interacting protein 2-like. (436 aa)
	gprc5b	G protein-coupled receptor, class C, group 5, member Bb. (410 aa)
	LOC103360163	Protein kinase C. (674 aa)
	ENSSPAP00000021368	Sharpin and rbck1 related. (688 aa)
	ENSSPAP00000020683	AGC-kinase C-terminal domain-containing protein. (57 aa)
	LOC103364666	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (680 aa)
	LOC103356890	Mitochondrial E3 ubiquitin protein ligase 1a. (353 aa)
	LOC103367996	Leucine rich adaptor protein 1. (363 aa)
	tmem101	Transmembrane protein 101. (255 aa)
	LOC103364934	Uncharacterized protein. (529 aa)
	ENSSPAP00000019823	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (602 aa)
	LOC103354167	Fas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family. (263 aa)
	map3k7	Mitogen-activated protein kinase kinase kinase 7. (601 aa)
	LOC103356842	Glyceraldehyde-3-phosphate dehydrogenase. (345 aa)
	LOC103367454	Si:dkey-163m14.2; Belongs to the G-protein coupled receptor 1 family. (439 aa)
	LOC103368637	DEAH (Asp-Glu-Ala-His) box helicase 15. (765 aa)
	LOC103365125	DEAD (Asp-Glu-Ala-Asp) box helicase 21. (754 aa)
	prkcb	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (667 aa)
	myd88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (286 aa)
	ikbke	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (721 aa)
	LOC103374229	Mitogen-activated protein kinase kinase kinase 14a. (859 aa)
	tradd	Tnfrsf1a-associated via death domain. (292 aa)
	trim8	Tripartite motif containing 8b. (595 aa)
	ALPK1	Alpha kinase 1. (889 aa)
	rbck1	RanBP-type and C3HC4-type zinc finger containing 1. (519 aa)
	LOC103370178	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (270 aa)
	LOC103360712	G protein-coupled receptor, class C, group 5, member Ba. (397 aa)
	ajuba	Ajuba LIM protein. (730 aa)
	card11	Caspase recruitment domain family, member 11. (1164 aa)
	ENSSPAP00000010586	Si:ch211-15b10.6. (181 aa)
	terf2ip	Uncharacterized protein. (715 aa)
	ikbkb	Inhibitor of nuclear factor kappa B kinase subunit beta. (685 aa)
	LOC103369525	ADP-ribosylation factor 2b. (886 aa)
	trim62	Tripartite motif containing 62, tandem duplicate 1. (475 aa)
	LOC103369011	Component of inhibitor of nuclear factor kappa B kinase complex. (735 aa)
	LOC103370644	CD40 molecule, TNF receptor superfamily member 5. (300 aa)
	inava	Innate immunity activator a. (591 aa)
	JMJD8	Jumonji domain containing 8. (180 aa)
	C18orf32	Chromosome 18 open reading frame 32. (81 aa)
	prkn	RBR-type E3 ubiquitin transferase. (341 aa)
	cth	Cystathionase (cystathionine gamma-lyase), like. (403 aa)
	LOC103366604	Uncharacterized protein. (301 aa)
	rnf31	Uncharacterized protein. (1150 aa)
	TIRAP	TIR domain containing adaptor protein. (238 aa)
	ENSSPAP00000005790	Protein kinase domain-containing protein. (138 aa)
	LURAP1L	Leucine rich adaptor protein 1 like. (236 aa)
	ENSSPAP00000005072	Protein kinase domain-containing protein. (120 aa)
	LOC103370560	Bromodomain containing 4. (1543 aa)
	ENSSPAP00000003306	RING-type domain-containing protein. (568 aa)
	tnfsf10	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (287 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (582 aa)
	LOC103359374	Innate immunity activator b. (617 aa)
	ENSSPAP00000002820	Uncharacterized protein. (45 aa)
	LOC103362164	Uncharacterized protein. (1002 aa)
	ENSSPAP00000002342	Gp_dh_N domain-containing protein. (181 aa)
	LOC103375115	Uncharacterized protein; Belongs to the peptidase C14A family. (497 aa)
	LOC103376304	Glyceraldehyde-3-phosphate dehydrogenase. (339 aa)

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALPK1	ENSSPAP00000005072	ENSSPAP00000012703	ENSSPAP00000005072	Alpha kinase 1.	Protein kinase domain-containing protein.	0.616
ALPK1	ENSSPAP00000010586	ENSSPAP00000012703	ENSSPAP00000010586	Alpha kinase 1.	Si:ch211-15b10.6.	0.862
ALPK1	map3k7	ENSSPAP00000012703	ENSSPAP00000019194	Alpha kinase 1.	Mitogen-activated protein kinase kinase kinase 7.	0.616
ALPK1	ripk2	ENSSPAP00000012703	ENSSPAP00000002933	Alpha kinase 1.	Receptor-interacting serine-threonine kinase 2.	0.469
DHX15	LOC103362164	ENSSPAP00000027809	ENSSPAP00000002502	DEAH-box helicase 15.	Uncharacterized protein.	0.521
DHX15	LOC103365125	ENSSPAP00000027809	ENSSPAP00000017417	DEAH-box helicase 15.	DEAD (Asp-Glu-Ala-Asp) box helicase 21.	0.805
DHX15	LOC103368637	ENSSPAP00000027809	ENSSPAP00000018157	DEAH-box helicase 15.	DEAH (Asp-Glu-Ala-His) box helicase 15.	0.898
DHX15	LOC103373869	ENSSPAP00000027809	ENSSPAP00000027265	DEAH-box helicase 15.	Si:dkey-181m9.8.	0.521
DHX15	ddx1	ENSSPAP00000027809	ENSSPAP00000031421	DEAH-box helicase 15.	DEAD (Asp-Glu-Ala-Asp) box helicase 1.	0.775
DHX15	dhx36	ENSSPAP00000027809	ENSSPAP00000029510	DEAH-box helicase 15.	DEAH (Asp-Glu-Ala-His) box polypeptide 36.	0.602
DHX15	myd88	ENSSPAP00000027809	ENSSPAP00000015555	DEAH-box helicase 15.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.428
DHX15	rnf31	ENSSPAP00000027809	ENSSPAP00000007115	DEAH-box helicase 15.	Uncharacterized protein.	0.521
ENSSPAP00000002342	ENSSPAP00000005072	ENSSPAP00000002342	ENSSPAP00000005072	Gp_dh_N domain-containing protein.	Protein kinase domain-containing protein.	0.504
ENSSPAP00000002342	cth	ENSSPAP00000002342	ENSSPAP00000007537	Gp_dh_N domain-containing protein.	Cystathionase (cystathionine gamma-lyase), like.	0.470
ENSSPAP00000002342	fadd	ENSSPAP00000002342	ENSSPAP00000028894	Gp_dh_N domain-containing protein.	Uncharacterized protein.	0.533
ENSSPAP00000002342	map3k7	ENSSPAP00000002342	ENSSPAP00000019194	Gp_dh_N domain-containing protein.	Mitogen-activated protein kinase kinase kinase 7.	0.504
ENSSPAP00000002342	prkn	ENSSPAP00000002342	ENSSPAP00000007653	Gp_dh_N domain-containing protein.	RBR-type E3 ubiquitin transferase.	0.401
ENSSPAP00000002342	ripk2	ENSSPAP00000002342	ENSSPAP00000002933	Gp_dh_N domain-containing protein.	Receptor-interacting serine-threonine kinase 2.	0.510
ENSSPAP00000002342	tradd	ENSSPAP00000002342	ENSSPAP00000013332	Gp_dh_N domain-containing protein.	Tnfrsf1a-associated via death domain.	0.806
ENSSPAP00000002820	ENSSPAP00000005072	ENSSPAP00000002820	ENSSPAP00000005072	Uncharacterized protein.	Protein kinase domain-containing protein.	0.908