(97 nodes) Regulation of MAP kinase activity network (Stegastes partitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSSPAP00000009628	UEV domain-containing protein. (86 aa)
	sh2b3	SH2B adaptor protein 3. (749 aa)
	LOC103359902	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (169 aa)
	cdk5rap3	CDK5 regulatory subunit associated protein 3. (503 aa)
	axin1	Axin 1. (814 aa)
	pdcd10	Programmed cell death 10a. (212 aa)
	ENSSPAP00000003300	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (208 aa)
	LOC103367716	Tribbles pseudokinase 3. (356 aa)
	ptprc	Protein tyrosine phosphatase receptor type C. (1045 aa)
	LOC103354460	Uncharacterized protein. (566 aa)
	p2rx7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (578 aa)
	ENSSPAP00000005072	Protein kinase domain-containing protein. (120 aa)
	PIK3R5	Phosphoinositide-3-kinase regulatory subunit 5. (877 aa)
	LOC103374573	Dopamine receptor D4a; Belongs to the G-protein coupled receptor 1 family. (382 aa)
	smpd1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (598 aa)
	LOC103373436	Uncharacterized protein. (206 aa)
	LOC103363373	Si:dkey-175m17.7. (872 aa)
	nf1	Neurofibromin 1b. (2780 aa)
	SPRY3	Sprouty RTK signaling antagonist 3. (321 aa)
	map2k7	Mitogen-activated protein kinase kinase 7. (439 aa)
	pdgfc	Platelet derived growth factor c. (351 aa)
	LOC103370624	Uncharacterized protein. (1669 aa)
	LOC103370644	CD40 molecule, TNF receptor superfamily member 5. (300 aa)
	LOC103366227	Uncharacterized protein. (886 aa)
	map3k4	Mitogen-activated protein kinase kinase kinase 4. (1587 aa)
	cav3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
	LOC103368476	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (166 aa)
	tsg101	Tumor susceptibility 101a. (390 aa)
	LOC103355977	Dual specificity phosphatase 19a. (198 aa)
	htr2b	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled. (473 aa)
	map2k5	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (438 aa)
	pdgfa	Platelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family. (226 aa)
	LOC103364206	SAM and SH3 domain containing 1b. (950 aa)
	sorl1	Sortilin-related receptor, L(DLR class) A repeats containing. (2133 aa)
	ENSSPAP00000026225	Dystrobrevin binding protein 1b. (237 aa)
	bmp4	Bone morphogenetic protein 4. (403 aa)
	LOC103371952	Uncharacterized protein. (341 aa)
	nox4	FAD-binding FR-type domain-containing protein. (559 aa)
	fzd4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (531 aa)
	LOC103365874	Programmed cell death 10b. (210 aa)
	LOC103359761	Progestin and adipoQ receptor family member IIIb. (314 aa)
	map3k13	Mitogen-activated protein kinase kinase kinase. (1014 aa)
	pik3r5	Phosphoinositide-3-kinase, regulatory subunit 5. (803 aa)
	LOC103362006	Si:rp71-17i16.5; Belongs to the PI3/PI4-kinase family. (1081 aa)
	vegfa	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (212 aa)
	LOC103362026	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
	gba	Glucosylceramidase. (411 aa)
	LOC103373263	Transforming growth factor beta; Belongs to the TGF-beta family. (384 aa)
	sash1	SAM and SH3 domain containing 1a. (1227 aa)
	spry2	Sprouty RTK signaling antagonist 2. (353 aa)
	ENSSPAP00000010882	Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (578 aa)
	dkk1	Dickkopf WNT signaling pathway inhibitor 1a. (253 aa)
	ajuba	Ajuba LIM protein. (730 aa)
	pik3cg	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1123 aa)
	drd4	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (381 aa)
	LOC103370178	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (270 aa)
	ENSSPAP00000012851	Uncharacterized protein. (127 aa)
	tmem130	Transmembrane protein 130. (305 aa)
	hgs	Hepatocyte growth factor-regulated tyrosine kinase substrate. (766 aa)
	LOC103373576	3-hydroxy-3-methylglutaryl coenzyme A reductase. (941 aa)
	LOC103363938	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	agt	Angiotensinogen; Belongs to the serpin family. (463 aa)
	LOC103364526	Bone morphogenetic protein 16. (476 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	ENSSPAP00000015132	Tpd52 like 1. (225 aa)
	spry1	Sprouty homolog 1, antagonist of FGF signaling (Drosophila). (360 aa)
	LOC103362339	Interleukin-1. (247 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	trib2	Tribbles pseudokinase 2. (346 aa)
	il34	Interleukin 34. (215 aa)
	fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (181 aa)
	spry4	Sprouty homolog 4 (Drosophila). (379 aa)
	lrrk2	Leucine-rich repeat kinase 2. (2421 aa)
	LOC103359141	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (149 aa)
	LOC103364579	Progestin and adipoQ receptor family member IIIa. (344 aa)
	LOC103358541	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (520 aa)
	LOC103359183	Endoplasmic reticulum to nucleus signaling 2. (854 aa)
	LOC103366446	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (409 aa)
	tenm1	Teneurin transmembrane protein 1. (2703 aa)
	ENSSPAP00000019170	Apolipoprotein Ea. (259 aa)
	map3k7	Mitogen-activated protein kinase kinase kinase 7. (601 aa)
	ENSSPAP00000019319	NIMA-related kinase 10. (732 aa)
	ENSSPAP00000019920	Uncharacterized protein. (101 aa)
	LOC103359245	Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family. (207 aa)
	LOC103353638	Fibroblast growth factor receptor. (833 aa)
	ENSSPAP00000020489	Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (589 aa)
	LOC103376406	Tribbles pseudokinase 1. (356 aa)
	aida	Axin interactor, dorsalization associated. (305 aa)
	dusp10	Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (472 aa)
	LOC103359300	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
	ern1	Endoplasmic reticulum to nucleus signaling 1. (1075 aa)
	hmgcr	3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
	ptpn5	Protein tyrosine phosphatase non-receptor type 5. (403 aa)
	pdgfb	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (569 aa)
	ENSSPAP00000023641	Transforming growth factor, alpha. (218 aa)
	LOC103361918	EGF-like domain-containing protein. (161 aa)
	LOC103376103	Tumor necrosis factor receptor superfamily, member 11a, NFKB activator. (661 aa)

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSPAP00000003300	ENSSPAP00000005072	ENSSPAP00000003300	ENSSPAP00000005072	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	Protein kinase domain-containing protein.	0.413
ENSSPAP00000003300	ENSSPAP00000019319	ENSSPAP00000003300	ENSSPAP00000019319	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	NIMA-related kinase 10.	0.411
ENSSPAP00000003300	LOC103353638	ENSSPAP00000003300	ENSSPAP00000020376	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	Fibroblast growth factor receptor.	0.837
ENSSPAP00000003300	LOC103359183	ENSSPAP00000003300	ENSSPAP00000017882	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	Endoplasmic reticulum to nucleus signaling 2.	0.411
ENSSPAP00000003300	ern1	ENSSPAP00000003300	ENSSPAP00000023317	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	Endoplasmic reticulum to nucleus signaling 1.	0.411
ENSSPAP00000003300	map3k7	ENSSPAP00000003300	ENSSPAP00000019194	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	Mitogen-activated protein kinase kinase kinase 7.	0.413
ENSSPAP00000003300	sorl1	ENSSPAP00000003300	ENSSPAP00000025930	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	Sortilin-related receptor, L(DLR class) A repeats containing.	0.480
ENSSPAP00000005072	ENSSPAP00000003300	ENSSPAP00000005072	ENSSPAP00000003300	Protein kinase domain-containing protein.	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	0.413
ENSSPAP00000005072	ENSSPAP00000019319	ENSSPAP00000005072	ENSSPAP00000019319	Protein kinase domain-containing protein.	NIMA-related kinase 10.	0.435
ENSSPAP00000005072	LOC103355977	ENSSPAP00000005072	ENSSPAP00000024413	Protein kinase domain-containing protein.	Dual specificity phosphatase 19a.	0.480
ENSSPAP00000005072	LOC103362006	ENSSPAP00000005072	ENSSPAP00000029152	Protein kinase domain-containing protein.	Si:rp71-17i16.5; Belongs to the PI3/PI4-kinase family.	0.526
ENSSPAP00000005072	LOC103362339	ENSSPAP00000005072	ENSSPAP00000015284	Protein kinase domain-containing protein.	Interleukin-1.	0.462
ENSSPAP00000005072	LOC103363373	ENSSPAP00000005072	ENSSPAP00000006536	Protein kinase domain-containing protein.	Si:dkey-175m17.7.	0.416
ENSSPAP00000005072	LOC103364526	ENSSPAP00000005072	ENSSPAP00000014913	Protein kinase domain-containing protein.	Bone morphogenetic protein 16.	0.424
ENSSPAP00000005072	LOC103366227	ENSSPAP00000005072	ENSSPAP00000009134	Protein kinase domain-containing protein.	Uncharacterized protein.	0.462
ENSSPAP00000005072	LOC103367716	ENSSPAP00000005072	ENSSPAP00000004452	Protein kinase domain-containing protein.	Tribbles pseudokinase 3.	0.545
ENSSPAP00000005072	LOC103370644	ENSSPAP00000005072	ENSSPAP00000008871	Protein kinase domain-containing protein.	CD40 molecule, TNF receptor superfamily member 5.	0.542
ENSSPAP00000005072	LOC103373263	ENSSPAP00000005072	ENSSPAP00000030243	Protein kinase domain-containing protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.471
ENSSPAP00000005072	LOC103376406	ENSSPAP00000005072	ENSSPAP00000020530	Protein kinase domain-containing protein.	Tribbles pseudokinase 1.	0.545
ENSSPAP00000005072	SPRY3	ENSSPAP00000005072	ENSSPAP00000007235	Protein kinase domain-containing protein.	Sprouty RTK signaling antagonist 3.	0.434