(107 nodes) Negative regulation of MAPK cascade network (Stegastes partitus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103368476	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (166 aa)
	LOC103358766	Ephrin-A1a; Belongs to the ephrin family. (227 aa)
	sh2b3	SH2B adaptor protein 3. (749 aa)
	LOC103374507	Mothers against decapentaplegic homolog. (472 aa)
	dusp2	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (315 aa)
	LOC103358823	Cylindromatosis (turban tumor syndrome), b. (681 aa)
	cdk5rap3	CDK5 regulatory subunit associated protein 3. (503 aa)
	atf3	Activating transcription factor 3. (210 aa)
	ENSSPAP00000003172	Uncharacterized protein. (83 aa)
	SMAD4	Mothers against decapentaplegic homolog. (528 aa)
	itgb1bp1	Integrin beta 1 binding protein 1. (198 aa)
	LOC103366646	Uncharacterized protein. (431 aa)
	LOC103354448	Peptidase S72 domain-containing protein. (910 aa)
	ENSSPAP00000004315	Uncharacterized protein. (1249 aa)
	LOC103372831	Elastin microfibril interfacer 1b. (1212 aa)
	LOC103356322	Ash1 (absent, small, or homeotic)-like (Drosophila). (2963 aa)
	ptprc	Protein tyrosine phosphatase receptor type C. (1045 aa)
	p2rx7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (578 aa)
	LOC103358884	Mothers against decapentaplegic homolog. (651 aa)
	smpd1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (598 aa)
	dact1	Dishevelled-binding antagonist of beta-catenin 1. (817 aa)
	LOC103364400	C18h3orf33 homolog (H. sapiens). (268 aa)
	LOC103352826	Uncharacterized protein. (551 aa)
	LOC103361651	Mothers against decapentaplegic homolog. (503 aa)
	LOC103373436	Uncharacterized protein. (206 aa)
	dusp5	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (376 aa)
	LOC103363373	Si:dkey-175m17.7. (872 aa)
	nf1	Neurofibromin 1b. (2780 aa)
	SPRY3	Sprouty RTK signaling antagonist 3. (321 aa)
	prkn	RBR-type E3 ubiquitin transferase. (341 aa)
	LOC103369006	Si:ch211-223p8.8; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (253 aa)
	LOC103369021	Dual specificity phosphatase 13a; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (384 aa)
	mecom	MDS1 and EVI1 complex locus. (1202 aa)
	cav3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
	dusp10	Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (472 aa)
	dusp27	Dual specificity phosphatase 27; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (1164 aa)
	vrk3	VRK serine/threonine kinase 3. (518 aa)
	hmgcr	3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
	ptpn5	Protein tyrosine phosphatase non-receptor type 5. (403 aa)
	spred3	Sprouty related EVH1 domain containing 3. (525 aa)
	LOC103355977	Dual specificity phosphatase 19a. (198 aa)
	dusp1	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (376 aa)
	men1	Multiple endocrine neoplasia I. (626 aa)
	TIMP3	TIMP metallopeptidase inhibitor 3. (214 aa)
	phb	Prohibitin. (271 aa)
	LOC103371505	Tyrosine-protein phosphatase non-receptor type. (408 aa)
	sorl1	Sortilin-related receptor, L(DLR class) A repeats containing. (2133 aa)
	DUSP13	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (183 aa)
	LOC103355373	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (275 aa)
	LOC103355376	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (189 aa)
	LOC103372579	Inhibitor_Mig-6 domain-containing protein. (351 aa)
	LOC103368780	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (369 aa)
	cyld	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family. (917 aa)
	bmp4	Bone morphogenetic protein 4. (403 aa)
	LOC103357502	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (384 aa)
	LOC103371952	Uncharacterized protein. (341 aa)
	LOC103367618	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (195 aa)
	LOC103373881	Uncharacterized protein. (460 aa)
	LOC103361988	WNK lysine deficient protein kinase 2. (2640 aa)
	LOC103372632	Si:ch211-153j24.3. (385 aa)
	dusp4	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (368 aa)
	LOC103376215	TNFAIP3 interacting protein 1. (688 aa)
	LOC103359761	Progestin and adipoQ receptor family member IIIb. (314 aa)
	LOC103355463	E3 ubiquitin-protein ligase. (868 aa)
	efna1	Ephrin-A1b; Belongs to the ephrin family. (234 aa)
	dab2	DAB adaptor protein 2. (787 aa)
	LOC103356527	Uncharacterized protein. (1928 aa)
	gba	Glucosylceramidase. (411 aa)
	LOC103371033	Dystroglycan 1. (891 aa)
	errfi1	ERBB receptor feedback inhibitor 1a. (425 aa)
	spry2	Sprouty RTK signaling antagonist 2. (353 aa)
	foxm1	Forkhead box M1. (579 aa)
	LOC103357298	Cylindromatosis (turban tumor syndrome), like; Belongs to the peptidase C19 family. (773 aa)
	fktn	Fukutin. (458 aa)
	DUSP26	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (200 aa)
	LOC103372345	Elastin microfibril interfacer 1a. (1037 aa)
	tmem130	Transmembrane protein 130. (305 aa)
	PRDM15	PR/SET domain 15. (1079 aa)
	qars1	Glutaminyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (775 aa)
	LOC103373576	3-hydroxy-3-methylglutaryl coenzyme A reductase. (941 aa)
	pin1	Peptidyl-prolyl cis-trans isomerase. (156 aa)
	PEBP4	Phosphatidylethanolamine binding protein 4. (192 aa)
	agt	Angiotensinogen; Belongs to the serpin family. (463 aa)
	LOC103364526	Bone morphogenetic protein 16. (476 aa)
	spry1	Sprouty homolog 1, antagonist of FGF signaling (Drosophila). (360 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	spry4	Sprouty homolog 4 (Drosophila). (379 aa)
	LOC103355780	Uncharacterized protein. (897 aa)
	LOC103359145	SH3 domain containing ring finger 2. (860 aa)
	spred2	Sprouty related EVH1 domain containing 2a. (424 aa)
	LOC103364579	Progestin and adipoQ receptor family member IIIa. (344 aa)
	LOC103373135	Peptidase S72 domain-containing protein. (881 aa)
	ptpn1	Tyrosine-protein phosphatase non-receptor type. (438 aa)
	ptpn2	Tyrosine-protein phosphatase non-receptor type. (413 aa)
	ENSSPAP00000019170	Apolipoprotein Ea. (259 aa)
	zmynd11	Zinc finger, MYND-type containing 11. (595 aa)
	LOC103354691	Proteasome 26S subunit, non-ATPase 10. (227 aa)
	dusp6	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (383 aa)
	spred1	Sprouty related EVH1 domain containing 1. (450 aa)
	ENSSPAP00000021286	FERM domain-containing protein. (84 aa)
	LOC103376067	TNFAIP3 interacting protein 1. (658 aa)
	ENSSPAP00000021577	Protein kinase domain-containing protein. (625 aa)
	ENSSPAP00000021595	Uncharacterized protein. (348 aa)
	ENSSPAP00000021681	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (377 aa)
	aida	Axin interactor, dorsalization associated. (305 aa)
	LOC103370367	Neurofibromin 2b (merlin). (589 aa)
	flcn	Folliculin. (559 aa)

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DUSP13	LOC103357502	ENSSPAP00000025943	ENSSPAP00000026925	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.420
DUSP13	LOC103368780	ENSSPAP00000025943	ENSSPAP00000026395	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.420
DUSP13	dusp6	ENSSPAP00000025943	ENSSPAP00000020507	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.420
DUSP13	ptpn5	ENSSPAP00000025943	ENSSPAP00000023492	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Protein tyrosine phosphatase non-receptor type 5.	0.571
DUSP13	sorl1	ENSSPAP00000025943	ENSSPAP00000025930	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Sortilin-related receptor, L(DLR class) A repeats containing.	0.489
DUSP13	vrk3	ENSSPAP00000025943	ENSSPAP00000023047	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	VRK serine/threonine kinase 3.	0.645
DUSP26	LOC103357502	ENSSPAP00000012405	ENSSPAP00000026925	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.424
DUSP26	LOC103368780	ENSSPAP00000012405	ENSSPAP00000026395	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.424
DUSP26	dusp6	ENSSPAP00000012405	ENSSPAP00000020507	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.424
DUSP26	ptpn5	ENSSPAP00000012405	ENSSPAP00000023492	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Protein tyrosine phosphatase non-receptor type 5.	0.571
DUSP26	sorl1	ENSSPAP00000012405	ENSSPAP00000025930	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Sortilin-related receptor, L(DLR class) A repeats containing.	0.489
DUSP26	vrk3	ENSSPAP00000012405	ENSSPAP00000023047	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	VRK serine/threonine kinase 3.	0.645
ENSSPAP00000004315	LOC103368476	ENSSPAP00000004315	ENSSPAP00000009514	Uncharacterized protein.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.428
ENSSPAP00000004315	LOC103373881	ENSSPAP00000004315	ENSSPAP00000027628	Uncharacterized protein.	Uncharacterized protein.	0.517
ENSSPAP00000004315	cav3	ENSSPAP00000004315	ENSSPAP00000009502	Uncharacterized protein.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.428
ENSSPAP00000004315	phb	ENSSPAP00000004315	ENSSPAP00000025278	Uncharacterized protein.	Prohibitin.	0.470
ENSSPAP00000004315	spred1	ENSSPAP00000004315	ENSSPAP00000020550	Uncharacterized protein.	Sprouty related EVH1 domain containing 1.	0.517
ENSSPAP00000004315	spred2	ENSSPAP00000004315	ENSSPAP00000016634	Uncharacterized protein.	Sprouty related EVH1 domain containing 2a.	0.517
ENSSPAP00000004315	spred3	ENSSPAP00000004315	ENSSPAP00000024002	Uncharacterized protein.	Sprouty related EVH1 domain containing 3.	0.517
ENSSPAP00000019170	agt	ENSSPAP00000019170	ENSSPAP00000014878	Apolipoprotein Ea.	Angiotensinogen; Belongs to the serpin family.	0.497