(66 nodes) Mitotic DNA integrity checkpoint signaling network (Stegastes partitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	abraxas1	Abraxas 1, BRCA1 A complex subunit. (340 aa)
	cdc6	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (558 aa)
	rad17	RAD17 checkpoint clamp loader component. (637 aa)
	orc1	Origin recognition complex, subunit 1. (835 aa)
	dtl	Denticleless E3 ubiquitin protein ligase homolog (Drosophila). (644 aa)
	mus81	MUS81 structure-specific endonuclease subunit. (603 aa)
	babam2	BRISC and BRCA1 A complex member 2. (332 aa)
	blm	BLM RecQ like helicase. (1405 aa)
	casp2	Uncharacterized protein; Belongs to the peptidase C14A family. (290 aa)
	LOC103376010	P53-induced death domain protein 1. (884 aa)
	xpc	Xeroderma pigmentosum, complementation group C. (864 aa)
	ENSSPAP00000030409	Uncharacterized protein. (174 aa)
	LOC103371515	Uncharacterized protein. (492 aa)
	LOC103356490	TAO kinase 1a. (1025 aa)
	ccnd1	Cyclin D1; Belongs to the cyclin family. (292 aa)
	LOC103355430	SET domain and mariner transposase fusion gene. (296 aa)
	nop53	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (465 aa)
	CLSPN	Claspin. (1153 aa)
	cdca7	Cell division cycle associated 7a. (404 aa)
	LOC103366483	TAO kinase 1b. (1015 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (396 aa)
	wac	WW domain containing adaptor with coiled-coil a. (545 aa)
	taok3	TAO kinase 3a. (901 aa)
	ZNF830	Zinc finger protein 830. (345 aa)
	atm	Non-specific serine/threonine protein kinase. (3048 aa)
	LOC103374950	ERCC4 domain-containing protein. (426 aa)
	LOC103372520	WD_REPEATS_REGION domain-containing protein. (495 aa)
	msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (855 aa)
	ENSSPAP00000025275	Uncharacterized protein. (162 aa)
	tipin	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (300 aa)
	fancd2	FA complementation group D2. (1421 aa)
	eme1	Essential meiotic structure-specific endonuclease 1. (368 aa)
	LOC103354334	WW domain-containing protein. (533 aa)
	ticrr	Uncharacterized protein. (1749 aa)
	LOC103369977	Uncharacterized protein. (197 aa)
	hus1	Checkpoint protein; Belongs to the HUS1 family. (316 aa)
	taok2	Protein kinase domain-containing protein. (1248 aa)
	LOC103360500	Uncharacterized protein. (446 aa)
	cdk5rap3	CDK5 regulatory subunit associated protein 3. (503 aa)
	ENSSPAP00000003143	Uncharacterized protein. (100 aa)
	ENSSPAP00000003155	FHA domain-containing protein. (75 aa)
	ENSSPAP00000003584	Uncharacterized protein. (246 aa)
	brca1	Uncharacterized protein. (1411 aa)
	mre11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (698 aa)
	DONSON	Downstream neighbor of SON. (612 aa)
	babam1	BRISC and BRCA1 A complex member 1. (378 aa)
	cdk1	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (303 aa)
	rint1	RAD50 interactor 1. (797 aa)
	FZR1	Fizzy/cell division cycle 20 related 1a. (496 aa)
	LOC103364951	Fizzy/cell division cycle 20 related 1b. (519 aa)
	LOC103374609	Uncharacterized protein; Belongs to the cyclin family. (278 aa)
	LOC103369458	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (461 aa)
	LOC103374064	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (296 aa)
	cdca7l	zf-4CXXC_R1 domain-containing protein. (408 aa)
	foxn3	Checkpoint suppressor 1. (486 aa)
	ENSSPAP00000008441	Uncharacterized protein. (93 aa)
	ENSSPAP00000008480	TAO kinase 3b. (399 aa)
	mfsd11	Major facilitator superfamily domain containing 11. (455 aa)
	LOC103363962	TAO kinase 2a. (1141 aa)
	fbxo31	F-box protein 31. (591 aa)
	ENSSPAP00000010532	Uncharacterized protein. (142 aa)
	chek1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (457 aa)
	prkdc	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3883 aa)
	brcc3	BRCA1/BRCA2-containing complex, subunit 3. (265 aa)
	rfwd3	Ring finger and WD repeat domain 3. (727 aa)
	topbp1	DNA topoisomerase II binding protein 1. (1518 aa)

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLSPN	DONSON	ENSSPAP00000000476	ENSSPAP00000004603	Claspin.	Downstream neighbor of SON.	0.422
CLSPN	ENSSPAP00000010532	ENSSPAP00000000476	ENSSPAP00000010532	Claspin.	Uncharacterized protein.	0.696
CLSPN	ENSSPAP00000030409	ENSSPAP00000000476	ENSSPAP00000030409	Claspin.	Uncharacterized protein.	0.536
CLSPN	LOC103369458	ENSSPAP00000000476	ENSSPAP00000006903	Claspin.	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.681
CLSPN	atm	ENSSPAP00000000476	ENSSPAP00000022487	Claspin.	Non-specific serine/threonine protein kinase.	0.528
CLSPN	blm	ENSSPAP00000000476	ENSSPAP00000018586	Claspin.	BLM RecQ like helicase.	0.680
CLSPN	brca1	ENSSPAP00000000476	ENSSPAP00000003607	Claspin.	Uncharacterized protein.	0.864
CLSPN	casp2	ENSSPAP00000000476	ENSSPAP00000019445	Claspin.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.681
CLSPN	cdc6	ENSSPAP00000000476	ENSSPAP00000013857	Claspin.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.909
CLSPN	cdca7	ENSSPAP00000000476	ENSSPAP00000000630	Claspin.	Cell division cycle associated 7a.	0.614
CLSPN	cdca7l	ENSSPAP00000000476	ENSSPAP00000007855	Claspin.	zf-4CXXC_R1 domain-containing protein.	0.614
CLSPN	cdk1	ENSSPAP00000000476	ENSSPAP00000005346	Claspin.	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	0.681
CLSPN	chek1	ENSSPAP00000000476	ENSSPAP00000010619	Claspin.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.990
CLSPN	fancd2	ENSSPAP00000000476	ENSSPAP00000026968	Claspin.	FA complementation group D2.	0.640
CLSPN	hus1	ENSSPAP00000000476	ENSSPAP00000001489	Claspin.	Checkpoint protein; Belongs to the HUS1 family.	0.569
CLSPN	orc1	ENSSPAP00000000476	ENSSPAP00000015820	Claspin.	Origin recognition complex, subunit 1.	0.939
CLSPN	rad17	ENSSPAP00000000476	ENSSPAP00000015769	Claspin.	RAD17 checkpoint clamp loader component.	0.659
CLSPN	rad9a	ENSSPAP00000000476	ENSSPAP00000020960	Claspin.	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.696
CLSPN	ticrr	ENSSPAP00000000476	ENSSPAP00000027428	Claspin.	Uncharacterized protein.	0.664
CLSPN	tipin	ENSSPAP00000000476	ENSSPAP00000025810	Claspin.	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.946