(30 nodes) Embryonic viscerocranium morphogenesis network (Stegastes partitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (415 aa)
	med12	Med12 domain-containing protein. (2087 aa)
	tbx1	T-box transcription factor 1. (501 aa)
	bmp2	Bone morphogenetic protein 2b. (416 aa)
	LOC103366847	RNA polymerase I and III subunit D. (114 aa)
	RAD21	RAD21 cohesin complex component. (624 aa)
	LOC103372412	Uncharacterized protein. (557 aa)
	egr1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (512 aa)
	wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	mmachc	Metabolism of cobalamin associated C. (266 aa)
	ENSSPAP00000020133	Rad21_Rec8_N domain-containing protein. (154 aa)
	LOC103369854	Uncharacterized protein. (324 aa)
	dlx5	Distal-less homeobox 5a. (285 aa)
	LOC103353832	RAD21 cohesin complex component a. (632 aa)
	wnt5b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa)
	gnptab	N-acetylglucosamine-1-phosphate transferase subunits alpha and beta. (1261 aa)
	nbas	Neuroblastoma amplified sequence. (1975 aa)
	ENSSPAP00000006493	Uncharacterized protein. (104 aa)
	LOC103364407	Activated leukocyte cell adhesion molecule b. (572 aa)
	LOC103367232	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	LOC103362938	Nipped-B protein. (2290 aa)
	ENSSPAP00000000647	Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
	hand2	Heart and neural crest derivatives expressed 2. (218 aa)
	fst	Follistatin a. (348 aa)
	dlx3	Distal-less homeobox 3b. (280 aa)
	dlx2	Distal-less homeobox 2b. (276 aa)
	dlx1	Distal-less homeobox 1a. (251 aa)
	ENSSPAP00000007934	HintC domain-containing protein. (246 aa)
	pitx2	Homeobox protein. (313 aa)
	LOC103361657	Nipped-B protein. (2568 aa)

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSPAP00000006493	ENSSPAP00000020133	ENSSPAP00000006493	ENSSPAP00000020133	Uncharacterized protein.	Rad21_Rec8_N domain-containing protein.	0.928
ENSSPAP00000006493	LOC103353832	ENSSPAP00000006493	ENSSPAP00000029239	Uncharacterized protein.	RAD21 cohesin complex component a.	0.928
ENSSPAP00000006493	LOC103361657	ENSSPAP00000006493	ENSSPAP00000006614	Uncharacterized protein.	Nipped-B protein.	0.900
ENSSPAP00000006493	RAD21	ENSSPAP00000006493	ENSSPAP00000018381	Uncharacterized protein.	RAD21 cohesin complex component.	0.928
ENSSPAP00000020133	ENSSPAP00000006493	ENSSPAP00000020133	ENSSPAP00000006493	Rad21_Rec8_N domain-containing protein.	Uncharacterized protein.	0.928
ENSSPAP00000020133	LOC103361657	ENSSPAP00000020133	ENSSPAP00000006614	Rad21_Rec8_N domain-containing protein.	Nipped-B protein.	0.928
ENSSPAP00000020133	LOC103362938	ENSSPAP00000020133	ENSSPAP00000012760	Rad21_Rec8_N domain-containing protein.	Nipped-B protein.	0.928
ENSSPAP00000020133	egr1	ENSSPAP00000020133	ENSSPAP00000018603	Rad21_Rec8_N domain-containing protein.	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family.	0.459
ENSSPAP00000020133	gnptab	ENSSPAP00000020133	ENSSPAP00000031058	Rad21_Rec8_N domain-containing protein.	N-acetylglucosamine-1-phosphate transferase subunits alpha and beta.	0.497
LOC103353832	ENSSPAP00000006493	ENSSPAP00000029239	ENSSPAP00000006493	RAD21 cohesin complex component a.	Uncharacterized protein.	0.928
LOC103353832	LOC103361657	ENSSPAP00000029239	ENSSPAP00000006614	RAD21 cohesin complex component a.	Nipped-B protein.	0.928
LOC103353832	LOC103362938	ENSSPAP00000029239	ENSSPAP00000012760	RAD21 cohesin complex component a.	Nipped-B protein.	0.928
LOC103353832	RAD21	ENSSPAP00000029239	ENSSPAP00000018381	RAD21 cohesin complex component a.	RAD21 cohesin complex component.	0.909
LOC103353832	egr1	ENSSPAP00000029239	ENSSPAP00000018603	RAD21 cohesin complex component a.	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family.	0.459
LOC103353832	gnptab	ENSSPAP00000029239	ENSSPAP00000031058	RAD21 cohesin complex component a.	N-acetylglucosamine-1-phosphate transferase subunits alpha and beta.	0.497
LOC103361657	ENSSPAP00000006493	ENSSPAP00000006614	ENSSPAP00000006493	Nipped-B protein.	Uncharacterized protein.	0.900
LOC103361657	ENSSPAP00000020133	ENSSPAP00000006614	ENSSPAP00000020133	Nipped-B protein.	Rad21_Rec8_N domain-containing protein.	0.928
LOC103361657	LOC103353832	ENSSPAP00000006614	ENSSPAP00000029239	Nipped-B protein.	RAD21 cohesin complex component a.	0.928
LOC103361657	RAD21	ENSSPAP00000006614	ENSSPAP00000018381	Nipped-B protein.	RAD21 cohesin complex component.	0.928
LOC103362938	ENSSPAP00000020133	ENSSPAP00000012760	ENSSPAP00000020133	Nipped-B protein.	Rad21_Rec8_N domain-containing protein.	0.928