(85 nodes) Negative regulation of neurogenesis network (Stegastes partitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103371090	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fb; Belongs to the semaphorin family. (805 aa)
	LOC103360390	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6E; Belongs to the semaphorin family. (1089 aa)
	rufy3	RUN and FYVE domain containing 3. (596 aa)
	LOC103373259	Si:ch73-40a2.1. (817 aa)
	sema4b	Sema domain-containing protein; Belongs to the semaphorin family. (837 aa)
	rtn4r	Reticulon 4 receptor. (467 aa)
	LOC103364805	Sema domain-containing protein; Belongs to the semaphorin family. (797 aa)
	sema5a	Sema domain-containing protein. (1078 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	sema6d	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like; Belongs to the semaphorin family. (1030 aa)
	dip2a	Disco-interacting protein 2 homolog A. (1586 aa)
	nkx6-2	NK6 homeobox 2. (283 aa)
	LOC103361999	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
	LOC103367103	RHD domain-containing protein. (643 aa)
	brinp1	Bone morphogenetic protein/retinoic acid inducible neural-specific 1. (761 aa)
	LOC103354313	Uncharacterized protein; Belongs to the semaphorin family. (638 aa)
	LOC103360486	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa; Belongs to the semaphorin family. (790 aa)
	sorl1	Sortilin-related receptor, L(DLR class) A repeats containing. (2133 aa)
	LOC103362574	Si:ch211-113g11.6; Belongs to the semaphorin family. (613 aa)
	nr1d1	Nuclear receptor subfamily 1, group d, member 1. (514 aa)
	LOC103355343	DMAP-interaction domain-containing protein. (1283 aa)
	kifap3	Kinesin-associated protein 3b. (777 aa)
	ENSSPAP00000024167	Sema domain-containing protein. (625 aa)
	ENSSPAP00000024074	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
	sema7a	Semaphorin 7A; Belongs to the semaphorin family. (683 aa)
	ryk	Receptor like tyrosine kinase. (646 aa)
	LOC103361455	Uncharacterized protein; Belongs to the semaphorin family. (817 aa)
	LOC103369817	Sema domain-containing protein; Belongs to the semaphorin family. (792 aa)
	ENSSPAP00000022565	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (335 aa)
	dnajb11	DnaJ heat shock protein family (Hsp40) member B11. (360 aa)
	LOC103370367	Neurofibromin 2b (merlin). (589 aa)
	ENSSPAP00000021286	FERM domain-containing protein. (84 aa)
	LOC103353645	Unc-51 like autophagy activating kinase 1a. (899 aa)
	LOC103357999	Notch receptor 1a. (2480 aa)
	rnf10	Ring finger protein 10. (787 aa)
	sema3g	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3bl; Belongs to the semaphorin family. (766 aa)
	LOC103369200	Disco interacting protein 2 homolog C. (1316 aa)
	sema3b	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B; Belongs to the semaphorin family. (812 aa)
	sema3e	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; Belongs to the semaphorin family. (666 aa)
	sema3a	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ab; Belongs to the semaphorin family. (805 aa)
	sema3d	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D; Belongs to the semaphorin family. (949 aa)
	LOC103369187	Si:ch211-129c21.1; Belongs to the semaphorin family. (804 aa)
	ulk1	Unc-51 like autophagy activating kinase 1. (1025 aa)
	med23	Mediator complex subunit 23. (1345 aa)
	rapgef2	Rap guanine nucleotide exchange factor (GEF) 2. (1603 aa)
	sema3c	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C; Belongs to the semaphorin family. (768 aa)
	pcm1	Pericentriolar material 1. (1898 aa)
	nfatc4	Nuclear factor of activated T cells 4. (551 aa)
	SEMA6A	Semaphorin 6A; Belongs to the semaphorin family. (548 aa)
	LOC103371265	Sema domain-containing protein. (1081 aa)
	cdk5	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	LOC103358497	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Aa; Belongs to the semaphorin family. (864 aa)
	ENSSPAP00000015034	Sema domain-containing protein; Belongs to the semaphorin family. (387 aa)
	LOC103368553	Sema domain-containing protein; Belongs to the semaphorin family. (836 aa)
	LOC103367378	Sema domain-containing protein. (1130 aa)
	LOC103365074	Eph receptor A4, like. (989 aa)
	ulk2	Unc-51 like autophagy activating kinase 2. (1026 aa)
	sema4c	Uncharacterized protein; Belongs to the semaphorin family. (868 aa)
	LOC103373543	Neurogenin 1. (194 aa)
	LOC103354038	Sema domain-containing protein; Belongs to the semaphorin family. (691 aa)
	LOC103367355	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (290 aa)
	f2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (615 aa)
	nkx6-1	NK6 homeobox 1. (303 aa)
	LOC103363430	Spartin b. (604 aa)
	LOC103368268	Disco-interacting protein 2 homolog Ba. (1529 aa)
	ifrd1	Interferon-related developmental regulator 1. (428 aa)
	LOC103366738	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	LOC103353434	Notch receptor 1b. (2311 aa)
	LOC103360628	Uncharacterized protein; Belongs to the semaphorin family. (873 aa)
	ski	V-ski avian sarcoma viral oncogene homolog a. (746 aa)
	nf1	Neurofibromin 1b. (2780 aa)
	epha4	Uncharacterized protein. (1041 aa)
	rb1	Retinoblastoma 1. (909 aa)
	LOC103356750	Sema domain-containing protein; Belongs to the semaphorin family. (794 aa)
	tmem98	Transmembrane protein 98. (224 aa)
	dynlt1	Dynein, light chain, Tctex-type 1. (116 aa)
	SEMA4D	Semaphorin 4D; Belongs to the semaphorin family. (870 aa)
	LOC103364382	Semaphorin 4e; Belongs to the semaphorin family. (777 aa)
	LOC103364377	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Ba; Belongs to the semaphorin family. (849 aa)
	ifrd2	Interferon-related developmental regulator 2. (464 aa)
	id1	Inhibitor of DNA binding 1, HLH protein. (132 aa)
	sirt2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (380 aa)
	LOC103376574	Nuclear receptor subfamily 1, group D, member 4b. (571 aa)
	sema6b	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Bb; Belongs to the semaphorin family. (730 aa)
	dip2b	Disco-interacting protein 2 homolog Bb. (1611 aa)

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSPAP00000015034	ENSSPAP00000024167	ENSSPAP00000015034	ENSSPAP00000024167	Sema domain-containing protein; Belongs to the semaphorin family.	Sema domain-containing protein.	0.896
ENSSPAP00000015034	LOC103356750	ENSSPAP00000015034	ENSSPAP00000005920	Sema domain-containing protein; Belongs to the semaphorin family.	Sema domain-containing protein; Belongs to the semaphorin family.	0.440
ENSSPAP00000015034	LOC103368553	ENSSPAP00000015034	ENSSPAP00000014081	Sema domain-containing protein; Belongs to the semaphorin family.	Sema domain-containing protein; Belongs to the semaphorin family.	0.440
ENSSPAP00000015034	LOC103369817	ENSSPAP00000015034	ENSSPAP00000022726	Sema domain-containing protein; Belongs to the semaphorin family.	Sema domain-containing protein; Belongs to the semaphorin family.	0.440
ENSSPAP00000015034	SEMA4D	ENSSPAP00000015034	ENSSPAP00000004659	Sema domain-containing protein; Belongs to the semaphorin family.	Semaphorin 4D; Belongs to the semaphorin family.	0.456
ENSSPAP00000015034	cdk5	ENSSPAP00000015034	ENSSPAP00000015780	Sema domain-containing protein; Belongs to the semaphorin family.	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily.	0.522
ENSSPAP00000015034	sema4b	ENSSPAP00000015034	ENSSPAP00000030069	Sema domain-containing protein; Belongs to the semaphorin family.	Sema domain-containing protein; Belongs to the semaphorin family.	0.440
ENSSPAP00000021286	LOC103370367	ENSSPAP00000021286	ENSSPAP00000021848	FERM domain-containing protein.	Neurofibromin 2b (merlin).	0.832
ENSSPAP00000021286	nf1	ENSSPAP00000021286	ENSSPAP00000006844	FERM domain-containing protein.	Neurofibromin 1b.	0.497
ENSSPAP00000022565	ENSSPAP00000024074	ENSSPAP00000022565	ENSSPAP00000024074	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.507
ENSSPAP00000022565	LOC103367355	ENSSPAP00000022565	ENSSPAP00000011932	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.505
ENSSPAP00000022565	ryk	ENSSPAP00000022565	ENSSPAP00000023205	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Receptor like tyrosine kinase.	0.759
ENSSPAP00000022565	sorl1	ENSSPAP00000022565	ENSSPAP00000025930	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Sortilin-related receptor, L(DLR class) A repeats containing.	0.464
ENSSPAP00000024074	ENSSPAP00000022565	ENSSPAP00000024074	ENSSPAP00000022565	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.507
ENSSPAP00000024074	LOC103353434	ENSSPAP00000024074	ENSSPAP00000008461	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Notch receptor 1b.	0.423
ENSSPAP00000024074	LOC103357999	ENSSPAP00000024074	ENSSPAP00000020381	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Notch receptor 1a.	0.423
ENSSPAP00000024074	LOC103361999	ENSSPAP00000024074	ENSSPAP00000028380	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.498
ENSSPAP00000024074	LOC103366738	ENSSPAP00000024074	ENSSPAP00000009450	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.506
ENSSPAP00000024074	WNT7A	ENSSPAP00000024074	ENSSPAP00000028824	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.498
ENSSPAP00000024074	ryk	ENSSPAP00000024074	ENSSPAP00000023205	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Receptor like tyrosine kinase.	0.843