(39 nodes) Regulation of release of sequestered calcium ion into cytosol network (Stegastes partitus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ENSSPAP00000008856	Uncharacterized protein. (44 aa)
	calm1	Calmodulin 1. (149 aa)
	CXCR3	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (371 aa)
	LOC103370043	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (409 aa)
	LOC103354460	Uncharacterized protein. (566 aa)
	ENSSPAP00000004815	Uncharacterized protein. (1032 aa)
	LOC103362775	SH3 and cysteine rich domain 3. (332 aa)
	jph2	Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (769 aa)
	LOC103372224	Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (186 aa)
	LOC103362158	Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (681 aa)
	LOC103372325	Calmodulin 2a (phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
	htt	Huntingtin. (3035 aa)
	LOC103360672	Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (749 aa)
	LOC103352915	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (394 aa)
	sri	Uncharacterized protein. (185 aa)
	LOC103360297	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (465 aa)
	STAC3	SH3 and cysteine rich domain 3. (326 aa)
	selenon	Selenoprotein N. (552 aa)
	jph1	Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (693 aa)
	atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (264 aa)
	LOC103362614	Si:ch211-146m13.3. (697 aa)
	ENSSPAP00000028216	Apelin receptor b; Belongs to the G-protein coupled receptor 1 family. (370 aa)
	trpc1	Transient receptor potential cation channel, subfamily C, member 1; Belongs to the transient receptor (TC 1.A.4) family. (762 aa)
	LOC103370449	Calmodulin. (149 aa)
	ENSSPAP00000022765	Uncharacterized protein. (138 aa)
	ENSSPAP00000021681	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (377 aa)
	LOC103354614	Peptidylprolyl isomerase. (139 aa)
	ENSSPAP00000019920	Uncharacterized protein. (101 aa)
	LOC103367454	Si:dkey-163m14.2; Belongs to the G-protein coupled receptor 1 family. (439 aa)
	LOC103355794	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (454 aa)
	ENSSPAP00000015681	Apelin receptor a; Belongs to the G-protein coupled receptor 1 family. (362 aa)
	bax	BCL2 associated X, apoptosis regulator a. (192 aa)
	pln	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (53 aa)
	LOC103354601	Grancalcin. (249 aa)
	fkbp1a	Peptidylprolyl isomerase. (108 aa)
	clic2	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (243 aa)
	fkbp1b	Peptidylprolyl isomerase. (108 aa)
	LOC103353515	Calmodulin. (149 aa)
	f2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (615 aa)

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSPAP00000008856	LOC103353515	ENSSPAP00000008856	ENSSPAP00000012283	Uncharacterized protein.	Calmodulin.	0.784
ENSSPAP00000008856	LOC103370449	ENSSPAP00000008856	ENSSPAP00000025685	Uncharacterized protein.	Calmodulin.	0.784
ENSSPAP00000008856	LOC103372325	ENSSPAP00000008856	ENSSPAP00000000925	Uncharacterized protein.	Calmodulin 2a (phosphorylase kinase, delta); Belongs to the calmodulin family.	0.784
ENSSPAP00000008856	calm1	ENSSPAP00000008856	ENSSPAP00000008309	Uncharacterized protein.	Calmodulin 1.	0.784
ENSSPAP00000015681	ENSSPAP00000028216	ENSSPAP00000015681	ENSSPAP00000028216	Apelin receptor a; Belongs to the G-protein coupled receptor 1 family.	Apelin receptor b; Belongs to the G-protein coupled receptor 1 family.	0.899
ENSSPAP00000028216	ENSSPAP00000015681	ENSSPAP00000028216	ENSSPAP00000015681	Apelin receptor b; Belongs to the G-protein coupled receptor 1 family.	Apelin receptor a; Belongs to the G-protein coupled receptor 1 family.	0.899
LOC103352915	LOC103355794	ENSSPAP00000009347	ENSSPAP00000017128	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.803
LOC103352915	LOC103360297	ENSSPAP00000009347	ENSSPAP00000030563	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.829
LOC103352915	LOC103370043	ENSSPAP00000009347	ENSSPAP00000004931	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.899
LOC103352915	jph2	ENSSPAP00000009347	ENSSPAP00000003752	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.	0.437
LOC103353515	ENSSPAP00000008856	ENSSPAP00000012283	ENSSPAP00000008856	Calmodulin.	Uncharacterized protein.	0.784
LOC103353515	LOC103354614	ENSSPAP00000012283	ENSSPAP00000020210	Calmodulin.	Peptidylprolyl isomerase.	0.784
LOC103353515	fkbp1a	ENSSPAP00000012283	ENSSPAP00000013102	Calmodulin.	Peptidylprolyl isomerase.	0.784
LOC103353515	fkbp1b	ENSSPAP00000012283	ENSSPAP00000012644	Calmodulin.	Peptidylprolyl isomerase.	0.784
LOC103353515	trpc1	ENSSPAP00000012283	ENSSPAP00000027003	Calmodulin.	Transient receptor potential cation channel, subfamily C, member 1; Belongs to the transient receptor (TC 1.A.4) family.	0.555
LOC103354614	LOC103353515	ENSSPAP00000020210	ENSSPAP00000012283	Peptidylprolyl isomerase.	Calmodulin.	0.784
LOC103354614	LOC103370449	ENSSPAP00000020210	ENSSPAP00000025685	Peptidylprolyl isomerase.	Calmodulin.	0.784
LOC103354614	LOC103372325	ENSSPAP00000020210	ENSSPAP00000000925	Peptidylprolyl isomerase.	Calmodulin 2a (phosphorylase kinase, delta); Belongs to the calmodulin family.	0.784
LOC103354614	calm1	ENSSPAP00000020210	ENSSPAP00000008309	Peptidylprolyl isomerase.	Calmodulin 1.	0.784
LOC103355794	LOC103352915	ENSSPAP00000017128	ENSSPAP00000009347	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.803