(23 nodes) Chromosome separation network (Stegastes partitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	mlh1	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (738 aa)
	hfm1	Helicase for meiosis 1. (988 aa)
	ncaph2	Non-SMC condensin II complex, subunit H2. (586 aa)
	espl1	Extra spindle pole bodies like 1, separase. (2157 aa)
	ENSSPAP00000003152	BTB domain-containing protein. (1167 aa)
	ENSSPAP00000005592	Centromere protein X. (84 aa)
	top3a	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1030 aa)
	tex11	Testis expressed 11. (816 aa)
	top2b	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1611 aa)
	rmi1	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (716 aa)
	recql5	RecQ helicase-like 5. (1018 aa)
	meiob	Methionine sulfoxide reductase B1b. (430 aa)
	mus81	MUS81 structure-specific endonuclease subunit. (603 aa)
	ercc4	Excision repair cross-complementation group 4. (899 aa)
	LOC103368048	Helicase ATP-binding domain-containing protein. (374 aa)
	ankle1	Uncharacterized protein. (1037 aa)
	LOC103374950	ERCC4 domain-containing protein. (426 aa)
	ttk	Ttk protein kinase. (998 aa)
	eme1	Essential meiotic structure-specific endonuclease 1. (368 aa)
	dis3l2	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation. Belongs to the RNR ribonuclease family. DIS3L2 subfamily. (1052 aa)
	LOC103359841	Helicase C-terminal domain-containing protein. (1420 aa)
	ncaph	Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (693 aa)
	top2a	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1569 aa)

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSPAP00000003152	LOC103359841	ENSSPAP00000003152	ENSSPAP00000029830	BTB domain-containing protein.	Helicase C-terminal domain-containing protein.	0.979
ENSSPAP00000003152	LOC103368048	ENSSPAP00000003152	ENSSPAP00000022419	BTB domain-containing protein.	Helicase ATP-binding domain-containing protein.	0.979
ENSSPAP00000003152	LOC103374950	ENSSPAP00000003152	ENSSPAP00000022964	BTB domain-containing protein.	ERCC4 domain-containing protein.	0.695
ENSSPAP00000003152	eme1	ENSSPAP00000003152	ENSSPAP00000027217	BTB domain-containing protein.	Essential meiotic structure-specific endonuclease 1.	0.959
ENSSPAP00000003152	ercc4	ENSSPAP00000003152	ENSSPAP00000019941	BTB domain-containing protein.	Excision repair cross-complementation group 4.	0.986
ENSSPAP00000003152	mlh1	ENSSPAP00000003152	ENSSPAP00000029134	BTB domain-containing protein.	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	0.563
ENSSPAP00000003152	mus81	ENSSPAP00000003152	ENSSPAP00000018204	BTB domain-containing protein.	MUS81 structure-specific endonuclease subunit.	0.991
ENSSPAP00000003152	recql5	ENSSPAP00000003152	ENSSPAP00000014700	BTB domain-containing protein.	RecQ helicase-like 5.	0.781
ENSSPAP00000003152	rmi1	ENSSPAP00000003152	ENSSPAP00000010344	BTB domain-containing protein.	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae).	0.778
ENSSPAP00000003152	top3a	ENSSPAP00000003152	ENSSPAP00000007919	BTB domain-containing protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.798
ENSSPAP00000005592	LOC103359841	ENSSPAP00000005592	ENSSPAP00000029830	Centromere protein X.	Helicase C-terminal domain-containing protein.	0.954
ENSSPAP00000005592	LOC103368048	ENSSPAP00000005592	ENSSPAP00000022419	Centromere protein X.	Helicase ATP-binding domain-containing protein.	0.953
ENSSPAP00000005592	ercc4	ENSSPAP00000005592	ENSSPAP00000019941	Centromere protein X.	Excision repair cross-complementation group 4.	0.855
ENSSPAP00000005592	mus81	ENSSPAP00000005592	ENSSPAP00000018204	Centromere protein X.	MUS81 structure-specific endonuclease subunit.	0.804
LOC103359841	ENSSPAP00000003152	ENSSPAP00000029830	ENSSPAP00000003152	Helicase C-terminal domain-containing protein.	BTB domain-containing protein.	0.979
LOC103359841	ENSSPAP00000005592	ENSSPAP00000029830	ENSSPAP00000005592	Helicase C-terminal domain-containing protein.	Centromere protein X.	0.954
LOC103359841	LOC103368048	ENSSPAP00000029830	ENSSPAP00000022419	Helicase C-terminal domain-containing protein.	Helicase ATP-binding domain-containing protein.	0.999
LOC103359841	LOC103374950	ENSSPAP00000029830	ENSSPAP00000022964	Helicase C-terminal domain-containing protein.	ERCC4 domain-containing protein.	0.753
LOC103359841	eme1	ENSSPAP00000029830	ENSSPAP00000027217	Helicase C-terminal domain-containing protein.	Essential meiotic structure-specific endonuclease 1.	0.771
LOC103359841	ercc4	ENSSPAP00000029830	ENSSPAP00000019941	Helicase C-terminal domain-containing protein.	Excision repair cross-complementation group 4.	0.811