(38 nodes) Roof of mouth development network (Stegastes partitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (497 aa)
	LOC103374781	T-box transcription factor 3b. (569 aa)
	med25	Mediator complex subunit 25. (743 aa)
	LOC103369122	Ubiquitin-like domain-containing protein. (164 aa)
	meox2	Mesenchyme homeobox 2a. (315 aa)
	tcf21	Transcription factor 21. (173 aa)
	LOC103372019	Fraser extracellular matrix complex subunit 1. (3109 aa)
	msx1	Muscle segment homeobox 1a. (283 aa)
	nprl3	NPR3-like, GATOR1 complex subunit. (607 aa)
	sgpl1	Sphingosine-1-phosphate lyase 1. (564 aa)
	LOC103369854	Uncharacterized protein. (324 aa)
	LOC103356968	Uncharacterized protein. (655 aa)
	csrnp1	Cysteine-serine-rich nuclear protein 1b. (576 aa)
	dhrs3	Dehydrogenase/reductase (SDR family) member 3b; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
	wfikkn2	Info WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2a. (578 aa)
	ENSSPAP00000027952	Growth arrest-specific 1a. (251 aa)
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	snai2	Snail family zinc finger 2. (260 aa)
	pygo2	Pygopus homolog 2 (Drosophila). (586 aa)
	LOC103360282	Cysteine-serine-rich nuclear protein 1a. (584 aa)
	tgfbr2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (583 aa)
	LOC103374507	Mothers against decapentaplegic homolog. (472 aa)
	LOC103361279	Lymphoid enhancer-binding factor 1. (364 aa)
	SMAD4	Mothers against decapentaplegic homolog. (528 aa)
	pkdcc	Protein kinase domain containing, cytoplasmic b. (499 aa)
	LOC103358884	Mothers against decapentaplegic homolog. (651 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (542 aa)
	LOC103361651	Mothers against decapentaplegic homolog. (503 aa)
	WDPCP	WD repeat containing planar cell polarity effector. (634 aa)
	lrrc32	Leucine rich repeat containing 32. (704 aa)
	itgb6	Integrin beta; Belongs to the integrin beta chain family. (783 aa)
	itgb8	Integrin beta; Belongs to the integrin beta chain family. (802 aa)
	bbs7	Bardet-Biedl syndrome 7. (711 aa)
	ENSSPAP00000009775	Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1b. (301 aa)
	tbx3	T-box transcription factor 3a. (715 aa)
	tbx1	T-box transcription factor 1. (501 aa)
	ENSSPAP00000013840	Asp-B-Hydro_N domain-containing protein. (353 aa)
	LOC103363483	Mothers against decapentaplegic homolog. (476 aa)

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSPAP00000009775	pkdcc	ENSSPAP00000009775	ENSSPAP00000004655	Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1b.	Protein kinase domain containing, cytoplasmic b.	0.457
LOC103356968	LOC103372019	ENSSPAP00000024336	ENSSPAP00000020025	Uncharacterized protein.	Fraser extracellular matrix complex subunit 1.	0.467
LOC103356968	pkdcc	ENSSPAP00000024336	ENSSPAP00000004655	Uncharacterized protein.	Protein kinase domain containing, cytoplasmic b.	0.504
LOC103358884	LOC103361279	ENSSPAP00000005222	ENSSPAP00000002070	Mothers against decapentaplegic homolog.	Lymphoid enhancer-binding factor 1.	0.954
LOC103358884	LOC103361651	ENSSPAP00000005222	ENSSPAP00000005949	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.818
LOC103358884	LOC103363483	ENSSPAP00000005222	ENSSPAP00000014003	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.961
LOC103358884	SMAD4	ENSSPAP00000005222	ENSSPAP00000003348	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.819
LOC103358884	TGFBR2	ENSSPAP00000005222	ENSSPAP00000005290	Mothers against decapentaplegic homolog.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.799
LOC103358884	pkdcc	ENSSPAP00000005222	ENSSPAP00000004655	Mothers against decapentaplegic homolog.	Protein kinase domain containing, cytoplasmic b.	0.445
LOC103358884	snai2	ENSSPAP00000005222	ENSSPAP00000029327	Mothers against decapentaplegic homolog.	Snail family zinc finger 2.	0.428
LOC103358884	tgfbr2	ENSSPAP00000005222	ENSSPAP00000000373	Mothers against decapentaplegic homolog.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.799
LOC103360282	msx1	ENSSPAP00000030302	ENSSPAP00000020327	Cysteine-serine-rich nuclear protein 1a.	Muscle segment homeobox 1a.	0.465
LOC103361279	LOC103358884	ENSSPAP00000002070	ENSSPAP00000005222	Lymphoid enhancer-binding factor 1.	Mothers against decapentaplegic homolog.	0.954
LOC103361279	LOC103361651	ENSSPAP00000002070	ENSSPAP00000005949	Lymphoid enhancer-binding factor 1.	Mothers against decapentaplegic homolog.	0.954
LOC103361279	LOC103363483	ENSSPAP00000002070	ENSSPAP00000014003	Lymphoid enhancer-binding factor 1.	Mothers against decapentaplegic homolog.	0.638
LOC103361279	LOC103374507	ENSSPAP00000002070	ENSSPAP00000001838	Lymphoid enhancer-binding factor 1.	Mothers against decapentaplegic homolog.	0.954
LOC103361279	SMAD4	ENSSPAP00000002070	ENSSPAP00000003348	Lymphoid enhancer-binding factor 1.	Mothers against decapentaplegic homolog.	0.954
LOC103361279	msx1	ENSSPAP00000002070	ENSSPAP00000020327	Lymphoid enhancer-binding factor 1.	Muscle segment homeobox 1a.	0.521
LOC103361279	pygo2	ENSSPAP00000002070	ENSSPAP00000029341	Lymphoid enhancer-binding factor 1.	Pygopus homolog 2 (Drosophila).	0.792
LOC103361279	wnt11	ENSSPAP00000002070	ENSSPAP00000029004	Lymphoid enhancer-binding factor 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.544