(91 nodes) Canonical Wnt signaling pathway network (Stegastes partitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	dvl1	Dishevelled segment polarity protein 1a. (728 aa)
	LOC103366738	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	LOC103368476	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (166 aa)
	LOC103366747	Dishevelled segment polarity protein 3a. (684 aa)
	FZD7	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (532 aa)
	LOC103365633	Phospholipid phosphatase 3. (307 aa)
	ENSSPAP00000010882	Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (578 aa)
	dkk1	Dickkopf WNT signaling pathway inhibitor 1a. (253 aa)
	LOC103352943	Endothelin receptor type Bb; Belongs to the G-protein coupled receptor 1 family. (436 aa)
	wnt2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
	LOC103367355	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (290 aa)
	LOC103355704	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	LOC103355705	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (340 aa)
	LOC103355142	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
	ENSSPAP00000012851	Uncharacterized protein. (127 aa)
	LOC103359554	Uncharacterized protein. (750 aa)
	ENSSPAP00000014660	Frizzled class receptor 9b; Belongs to the G-protein coupled receptor Fz/Smo family. (597 aa)
	wnt9b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	LOC103366846	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (414 aa)
	ctnnb1	Catenin (cadherin-associated protein), beta 1. (783 aa)
	scyl2	SCY1 like pseudokinase 2. (919 aa)
	sostdc1	Sclerostin domain containing 1a. (250 aa)
	ENSSPAP00000016624	HMG box domain-containing protein. (186 aa)
	ENSSPAP00000017112	Uncharacterized protein. (441 aa)
	ENSSPAP00000017156	DIX domain-containing protein. (55 aa)
	fzd3	Frizzled class receptor 3a; Belongs to the G-protein coupled receptor Fz/Smo family. (494 aa)
	ENSSPAP00000017789	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
	DIXDC1	DIX domain containing 1. (638 aa)
	sfrp5	Secreted frizzled-related protein 5. (321 aa)
	LOC103362426	Endothelin receptor type Ab. (313 aa)
	wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	wnt2b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (390 aa)
	ENSSPAP00000020489	Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (589 aa)
	wnt10b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (429 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	disc1	DISC1 scaffold protein. (848 aa)
	ENSSPAP00000022432	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (532 aa)
	ENSSPAP00000022565	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (335 aa)
	rspo1	R-spondin 1. (302 aa)
	wnt16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	ENSSPAP00000024074	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
	wnt9a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (376 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (314 aa)
	eda	Ectodysplasin A; Belongs to the tumor necrosis factor family. (382 aa)
	LOC103362533	Junction plakoglobin a. (729 aa)
	frzb	Frizzled related protein. (315 aa)
	ENSSPAP00000025069	Transcription factor 7 like 2. (401 aa)
	krtcap3	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (668 aa)
	LOC103364726	Transcription factor 7. (283 aa)
	fzd6	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (699 aa)
	ENSSPAP00000026365	Uncharacterized protein. (253 aa)
	LOC103371952	Uncharacterized protein. (341 aa)
	reck	Reversion-inducing-cysteine-rich protein with kazal motifs. (959 aa)
	fzd4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (531 aa)
	ENSSPAP00000027691	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (536 aa)
	LOC103361999	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
	sfrp1	Secreted frizzled-related protein 1a. (311 aa)
	LOC103354354	Endothelin receptor Ba; Belongs to the G-protein coupled receptor 1 family. (419 aa)
	LOC103371495	Uncharacterized protein. (768 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	LOC103356482	DIX domain containing 1a. (460 aa)
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	LOC103353239	Sizzled. (283 aa)
	pygo2	Pygopus homolog 2 (Drosophila). (586 aa)
	LOC103362026	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
	wnt5b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa)
	wnt10a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
	wnt6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	bcl9l	Bcl9 like. (1541 aa)
	tcf7l1	Transcription factor 7 like 1b. (581 aa)
	KCTD15	Potassium channel tetramerization domain containing 15a. (257 aa)
	LOC103366580	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (539 aa)
	ENSSPAP00000001266	HMG box domain-containing protein. (281 aa)
	LOC103361279	Lymphoid enhancer-binding factor 1. (364 aa)
	psen1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (491 aa)
	kctd15	BTB domain-containing protein. (270 aa)
	ednra	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (451 aa)
	LOC103358875	Homeobox domain-containing protein. (202 aa)
	LOC103356104	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
	ENSSPAP00000005369	Uncharacterized protein. (446 aa)
	LOC103356680	CTCK domain-containing protein. (208 aa)
	ENSSPAP00000005831	Low density lipoprotein receptor-related protein 6. (923 aa)
	LOC103367232	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	ENSSPAP00000005875	Uncharacterized protein. (453 aa)
	dvl2	Dishevelled segment polarity protein 2. (767 aa)
	LOC103374062	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (342 aa)
	LOC103366454	acidPPc domain-containing protein. (313 aa)
	ENSSPAP00000008527	FZ domain-containing protein. (120 aa)
	ENSSPAP00000008542	FZ domain-containing protein. (139 aa)
	bcl9	BCL9 transcription coactivator. (1495 aa)

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DIXDC1	disc1	ENSSPAP00000018058	ENSSPAP00000009073	DIX domain containing 1.	DISC1 scaffold protein.	0.533
ENSSPAP00000001266	LOC103359554	ENSSPAP00000001266	ENSSPAP00000013044	HMG box domain-containing protein.	Uncharacterized protein.	0.872
ENSSPAP00000001266	LOC103361279	ENSSPAP00000001266	ENSSPAP00000002070	HMG box domain-containing protein.	Lymphoid enhancer-binding factor 1.	0.863
ENSSPAP00000001266	LOC103362533	ENSSPAP00000001266	ENSSPAP00000024322	HMG box domain-containing protein.	Junction plakoglobin a.	0.872
ENSSPAP00000001266	LOC103364726	ENSSPAP00000001266	ENSSPAP00000025598	HMG box domain-containing protein.	Transcription factor 7.	0.767
ENSSPAP00000001266	LOC103371495	ENSSPAP00000001266	ENSSPAP00000028776	HMG box domain-containing protein.	Uncharacterized protein.	0.931
ENSSPAP00000001266	bcl9	ENSSPAP00000001266	ENSSPAP00000008973	HMG box domain-containing protein.	BCL9 transcription coactivator.	0.447
ENSSPAP00000001266	ctnnb1	ENSSPAP00000001266	ENSSPAP00000015579	HMG box domain-containing protein.	Catenin (cadherin-associated protein), beta 1.	0.981
ENSSPAP00000001266	pygo2	ENSSPAP00000001266	ENSSPAP00000029341	HMG box domain-containing protein.	Pygopus homolog 2 (Drosophila).	0.454
ENSSPAP00000001266	wnt4	ENSSPAP00000001266	ENSSPAP00000019747	HMG box domain-containing protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.402
ENSSPAP00000005369	ENSSPAP00000008527	ENSSPAP00000005369	ENSSPAP00000008527	Uncharacterized protein.	FZ domain-containing protein.	0.726
ENSSPAP00000005369	ENSSPAP00000008542	ENSSPAP00000005369	ENSSPAP00000008542	Uncharacterized protein.	FZ domain-containing protein.	0.726
ENSSPAP00000005369	ENSSPAP00000010882	ENSSPAP00000005369	ENSSPAP00000010882	Uncharacterized protein.	Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family.	0.769
ENSSPAP00000005369	ENSSPAP00000014660	ENSSPAP00000005369	ENSSPAP00000014660	Uncharacterized protein.	Frizzled class receptor 9b; Belongs to the G-protein coupled receptor Fz/Smo family.	0.859
ENSSPAP00000005369	ENSSPAP00000017112	ENSSPAP00000005369	ENSSPAP00000017112	Uncharacterized protein.	Uncharacterized protein.	0.765
ENSSPAP00000005369	ENSSPAP00000017156	ENSSPAP00000005369	ENSSPAP00000017156	Uncharacterized protein.	DIX domain-containing protein.	0.725
ENSSPAP00000005369	ENSSPAP00000017789	ENSSPAP00000005369	ENSSPAP00000017789	Uncharacterized protein.	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	0.874
ENSSPAP00000005369	ENSSPAP00000020489	ENSSPAP00000005369	ENSSPAP00000020489	Uncharacterized protein.	Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family.	0.769
ENSSPAP00000005369	ENSSPAP00000022432	ENSSPAP00000005369	ENSSPAP00000022432	Uncharacterized protein.	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.726
ENSSPAP00000005369	ENSSPAP00000022565	ENSSPAP00000005369	ENSSPAP00000022565	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.877