(12 nodes) Positive regulation of SMAD protein signal transduction network (Stegastes partitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	bmpr2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1067 aa)
	SMAD4	Mothers against decapentaplegic homolog. (528 aa)
	LOC103358884	Mothers against decapentaplegic homolog. (651 aa)
	LOC103361651	Mothers against decapentaplegic homolog. (503 aa)
	LOC103363883	RNA binding protein, mRNA processing factor. (165 aa)
	ENSSPAP00000006210	Uncharacterized protein. (109 aa)
	LOC103364526	Bone morphogenetic protein 16. (476 aa)
	LOC103369128	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1005 aa)
	bmp4	Bone morphogenetic protein 4. (403 aa)
	dab2	DAB adaptor protein 2. (787 aa)
	LOC103373263	Transforming growth factor beta; Belongs to the TGF-beta family. (384 aa)
	LOC103374507	Mothers against decapentaplegic homolog. (472 aa)

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103358884	LOC103361651	ENSSPAP00000005222	ENSSPAP00000005949	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.818
LOC103358884	LOC103364526	ENSSPAP00000005222	ENSSPAP00000014913	Mothers against decapentaplegic homolog.	Bone morphogenetic protein 16.	0.758
LOC103358884	LOC103369128	ENSSPAP00000005222	ENSSPAP00000016060	Mothers against decapentaplegic homolog.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.750
LOC103358884	LOC103373263	ENSSPAP00000005222	ENSSPAP00000030243	Mothers against decapentaplegic homolog.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.750
LOC103358884	SMAD4	ENSSPAP00000005222	ENSSPAP00000003348	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.819
LOC103358884	bmp4	ENSSPAP00000005222	ENSSPAP00000026584	Mothers against decapentaplegic homolog.	Bone morphogenetic protein 4.	0.758
LOC103358884	bmpr2	ENSSPAP00000005222	ENSSPAP00000030130	Mothers against decapentaplegic homolog.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.750
LOC103361651	LOC103358884	ENSSPAP00000005949	ENSSPAP00000005222	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.818
LOC103361651	LOC103364526	ENSSPAP00000005949	ENSSPAP00000014913	Mothers against decapentaplegic homolog.	Bone morphogenetic protein 16.	0.758
LOC103361651	LOC103369128	ENSSPAP00000005949	ENSSPAP00000016060	Mothers against decapentaplegic homolog.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.750
LOC103361651	LOC103373263	ENSSPAP00000005949	ENSSPAP00000030243	Mothers against decapentaplegic homolog.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.750
LOC103361651	LOC103374507	ENSSPAP00000005949	ENSSPAP00000001838	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.819
LOC103361651	SMAD4	ENSSPAP00000005949	ENSSPAP00000003348	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.830
LOC103361651	bmp4	ENSSPAP00000005949	ENSSPAP00000026584	Mothers against decapentaplegic homolog.	Bone morphogenetic protein 4.	0.789
LOC103361651	bmpr2	ENSSPAP00000005949	ENSSPAP00000030130	Mothers against decapentaplegic homolog.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.750
LOC103364526	LOC103358884	ENSSPAP00000014913	ENSSPAP00000005222	Bone morphogenetic protein 16.	Mothers against decapentaplegic homolog.	0.758
LOC103364526	LOC103361651	ENSSPAP00000014913	ENSSPAP00000005949	Bone morphogenetic protein 16.	Mothers against decapentaplegic homolog.	0.758
LOC103364526	LOC103369128	ENSSPAP00000014913	ENSSPAP00000016060	Bone morphogenetic protein 16.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.958
LOC103364526	LOC103374507	ENSSPAP00000014913	ENSSPAP00000001838	Bone morphogenetic protein 16.	Mothers against decapentaplegic homolog.	0.758
LOC103364526	SMAD4	ENSSPAP00000014913	ENSSPAP00000003348	Bone morphogenetic protein 16.	Mothers against decapentaplegic homolog.	0.758