(29 nodes) Sarcoplasmic reticulum membrane network (Stegastes partitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

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co-expression

protein homology

Your Input:
	LOC103371843	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (995 aa)
	ENSSPAP00000012234	Asp_Arg_Hydrox domain-containing protein. (130 aa)
	pln	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (53 aa)
	rnf175	Ring finger protein 175. (313 aa)
	ENSSPAP00000014464	B30.2/SPRY domain-containing protein. (334 aa)
	atp2a1	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (998 aa)
	cherp	Calcium homeostasis endoplasmic reticulum protein. (923 aa)
	ENSSPAP00000000694	Asp_Arg_Hydrox domain-containing protein. (92 aa)
	ENSSPAP00000004815	Uncharacterized protein. (1032 aa)
	rnf121	Ring finger protein 121. (332 aa)
	LOC103365013	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1036 aa)
	LOC103371166	Asp-B-Hydro_N domain-containing protein. (142 aa)
	LOC103360853	Peptidylprolyl isomerase. (108 aa)
	atp2a3	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (990 aa)
	ENSSPAP00000014779	Peptidylprolyl isomerase. (124 aa)
	LOC103356187	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1023 aa)
	atp2a2	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1035 aa)
	LOC103368261	Ryanodine receptor 1a (skeletal). (4896 aa)
	ENSSPAP00000029777	Asp-B-Hydro_N domain-containing protein. (197 aa)
	ENSSPAP00000026177	Uncharacterized protein. (913 aa)
	srl	Sarcalumenin; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (508 aa)
	ENSSPAP00000025091	Uncharacterized protein. (83 aa)
	ENSSPAP00000024801	Uncharacterized protein. (1008 aa)
	LOC103368738	Ryanodine receptor 1b (skeletal). (3789 aa)
	LOC103371333	Protein kinase domain-containing protein. (614 aa)
	ryr3	Ryanodine receptor 3. (4831 aa)
	ryr2	Ryanodine receptor 2b (cardiac). (4778 aa)
	asphd2	Aspartate beta-hydroxylase domain containing 2. (369 aa)
	LOC103372010	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (442 aa)

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSPAP00000000694	ENSSPAP00000014464	ENSSPAP00000000694	ENSSPAP00000014464	Asp_Arg_Hydrox domain-containing protein.	B30.2/SPRY domain-containing protein.	0.526
ENSSPAP00000000694	ENSSPAP00000014779	ENSSPAP00000000694	ENSSPAP00000014779	Asp_Arg_Hydrox domain-containing protein.	Peptidylprolyl isomerase.	0.516
ENSSPAP00000000694	ENSSPAP00000024801	ENSSPAP00000000694	ENSSPAP00000024801	Asp_Arg_Hydrox domain-containing protein.	Uncharacterized protein.	0.748
ENSSPAP00000000694	ENSSPAP00000026177	ENSSPAP00000000694	ENSSPAP00000026177	Asp_Arg_Hydrox domain-containing protein.	Uncharacterized protein.	0.775
ENSSPAP00000000694	LOC103360853	ENSSPAP00000000694	ENSSPAP00000018639	Asp_Arg_Hydrox domain-containing protein.	Peptidylprolyl isomerase.	0.516
ENSSPAP00000000694	LOC103368261	ENSSPAP00000000694	ENSSPAP00000030873	Asp_Arg_Hydrox domain-containing protein.	Ryanodine receptor 1a (skeletal).	0.883
ENSSPAP00000000694	LOC103368738	ENSSPAP00000000694	ENSSPAP00000024677	Asp_Arg_Hydrox domain-containing protein.	Ryanodine receptor 1b (skeletal).	0.883
ENSSPAP00000000694	ryr2	ENSSPAP00000000694	ENSSPAP00000019473	Asp_Arg_Hydrox domain-containing protein.	Ryanodine receptor 2b (cardiac).	0.775
ENSSPAP00000000694	ryr3	ENSSPAP00000000694	ENSSPAP00000020928	Asp_Arg_Hydrox domain-containing protein.	Ryanodine receptor 3.	0.883
ENSSPAP00000004815	ENSSPAP00000014464	ENSSPAP00000004815	ENSSPAP00000014464	Uncharacterized protein.	B30.2/SPRY domain-containing protein.	0.455
ENSSPAP00000004815	ENSSPAP00000024801	ENSSPAP00000004815	ENSSPAP00000024801	Uncharacterized protein.	Uncharacterized protein.	0.464
ENSSPAP00000004815	ENSSPAP00000026177	ENSSPAP00000004815	ENSSPAP00000026177	Uncharacterized protein.	Uncharacterized protein.	0.464
ENSSPAP00000004815	LOC103368261	ENSSPAP00000004815	ENSSPAP00000030873	Uncharacterized protein.	Ryanodine receptor 1a (skeletal).	0.464
ENSSPAP00000004815	LOC103368738	ENSSPAP00000004815	ENSSPAP00000024677	Uncharacterized protein.	Ryanodine receptor 1b (skeletal).	0.464
ENSSPAP00000004815	ryr2	ENSSPAP00000004815	ENSSPAP00000019473	Uncharacterized protein.	Ryanodine receptor 2b (cardiac).	0.464
ENSSPAP00000004815	ryr3	ENSSPAP00000004815	ENSSPAP00000020928	Uncharacterized protein.	Ryanodine receptor 3.	0.464
ENSSPAP00000012234	ENSSPAP00000014464	ENSSPAP00000012234	ENSSPAP00000014464	Asp_Arg_Hydrox domain-containing protein.	B30.2/SPRY domain-containing protein.	0.526
ENSSPAP00000012234	ENSSPAP00000024801	ENSSPAP00000012234	ENSSPAP00000024801	Asp_Arg_Hydrox domain-containing protein.	Uncharacterized protein.	0.526
ENSSPAP00000012234	ENSSPAP00000026177	ENSSPAP00000012234	ENSSPAP00000026177	Asp_Arg_Hydrox domain-containing protein.	Uncharacterized protein.	0.526
ENSSPAP00000012234	LOC103368261	ENSSPAP00000012234	ENSSPAP00000030873	Asp_Arg_Hydrox domain-containing protein.	Ryanodine receptor 1a (skeletal).	0.526