(17 nodes) Kringle, conserved site network (Stegastes partitus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	pik3ip1	Phosphoinositide-3-kinase interacting protein 1. (280 aa)
	LOC103357113	Uncharacterized protein; Belongs to the peptidase S1 family. (802 aa)
	LOC103365344	Hepatocyte growth factor a; Belongs to the peptidase S1 family. Plasminogen subfamily. (700 aa)
	ENSSPAP00000025109	Hyaluronan binding protein 2. (610 aa)
	plg	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (798 aa)
	ror1	Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (895 aa)
	ENSSPAP00000008117	Uncharacterized protein. (598 aa)
	mst1	Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (713 aa)
	LOC103369012	Plasminogen activator, urokinase a; Belongs to the peptidase S1 family. (399 aa)
	ror2	Receptor tyrosine kinase-like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (936 aa)
	plat	Plasminogen activator, tissue. (582 aa)
	ENSSPAP00000022269	Uncharacterized protein. (481 aa)
	kremen1	Kringle containing transmembrane protein 1. (461 aa)
	hgf	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (713 aa)
	hgfac	HGF activator. (597 aa)
	LOC103367384	Uncharacterized protein. (474 aa)
	f2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (615 aa)

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSPAP00000008117	ENSSPAP00000025109	ENSSPAP00000008117	ENSSPAP00000025109	Uncharacterized protein.	Hyaluronan binding protein 2.	0.736
ENSSPAP00000008117	LOC103365344	ENSSPAP00000008117	ENSSPAP00000028386	Uncharacterized protein.	Hepatocyte growth factor a; Belongs to the peptidase S1 family. Plasminogen subfamily.	0.424
ENSSPAP00000008117	f2	ENSSPAP00000008117	ENSSPAP00000011789	Uncharacterized protein.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.546
ENSSPAP00000008117	hgf	ENSSPAP00000008117	ENSSPAP00000019658	Uncharacterized protein.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.436
ENSSPAP00000008117	hgfac	ENSSPAP00000008117	ENSSPAP00000016121	Uncharacterized protein.	HGF activator.	0.659
ENSSPAP00000008117	kremen1	ENSSPAP00000008117	ENSSPAP00000021788	Uncharacterized protein.	Kringle containing transmembrane protein 1.	0.435
ENSSPAP00000008117	mst1	ENSSPAP00000008117	ENSSPAP00000008166	Uncharacterized protein.	Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily.	0.429
ENSSPAP00000008117	plat	ENSSPAP00000008117	ENSSPAP00000009892	Uncharacterized protein.	Plasminogen activator, tissue.	0.402
ENSSPAP00000008117	plg	ENSSPAP00000008117	ENSSPAP00000003802	Uncharacterized protein.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.561
ENSSPAP00000008117	ror1	ENSSPAP00000008117	ENSSPAP00000005140	Uncharacterized protein.	Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.653
ENSSPAP00000008117	ror2	ENSSPAP00000008117	ENSSPAP00000009537	Uncharacterized protein.	Receptor tyrosine kinase-like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.653
ENSSPAP00000022269	hgfac	ENSSPAP00000022269	ENSSPAP00000016121	Uncharacterized protein.	HGF activator.	0.562
ENSSPAP00000025109	ENSSPAP00000008117	ENSSPAP00000025109	ENSSPAP00000008117	Hyaluronan binding protein 2.	Uncharacterized protein.	0.736
ENSSPAP00000025109	LOC103365344	ENSSPAP00000025109	ENSSPAP00000028386	Hyaluronan binding protein 2.	Hepatocyte growth factor a; Belongs to the peptidase S1 family. Plasminogen subfamily.	0.409
ENSSPAP00000025109	f2	ENSSPAP00000025109	ENSSPAP00000011789	Hyaluronan binding protein 2.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.533
ENSSPAP00000025109	hgf	ENSSPAP00000025109	ENSSPAP00000019658	Hyaluronan binding protein 2.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.416
ENSSPAP00000025109	hgfac	ENSSPAP00000025109	ENSSPAP00000016121	Hyaluronan binding protein 2.	HGF activator.	0.656
ENSSPAP00000025109	kremen1	ENSSPAP00000025109	ENSSPAP00000021788	Hyaluronan binding protein 2.	Kringle containing transmembrane protein 1.	0.435
ENSSPAP00000025109	mst1	ENSSPAP00000025109	ENSSPAP00000008166	Hyaluronan binding protein 2.	Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily.	0.441
ENSSPAP00000025109	plat	ENSSPAP00000025109	ENSSPAP00000009892	Hyaluronan binding protein 2.	Plasminogen activator, tissue.	0.432