(11 nodes) Ubiquitin-activating enzyme network (Stegastes partitus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Input:
	uba1	Ubiquitin-like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family. (1057 aa)
	uba5	Ubiquitin-like modifier activating enzyme 5. (403 aa)
	sae1	SUMO1 activating enzyme subunit 1. (348 aa)
	uba2	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. (650 aa)
	atg7	ATG7 autophagy related 7 homolog (S. cerevisiae). (691 aa)
	nae1	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (533 aa)
	UBA3	Ubiquitin like modifier activating enzyme 3. (462 aa)
	mocs3	Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] (459 aa)
	LOC103360413	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family. (1013 aa)
	uba6	Ubiquitin like modifier activating enzyme 6. (1025 aa)
	LOC103359870	Ubiquitin-like modifier activating enzyme 3. (449 aa)

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103359870	LOC103360413	ENSSPAP00000031020	ENSSPAP00000026212	Ubiquitin-like modifier activating enzyme 3.	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	0.780
LOC103359870	UBA3	ENSSPAP00000031020	ENSSPAP00000025309	Ubiquitin-like modifier activating enzyme 3.	Ubiquitin like modifier activating enzyme 3.	0.898
LOC103359870	atg7	ENSSPAP00000031020	ENSSPAP00000010802	Ubiquitin-like modifier activating enzyme 3.	ATG7 autophagy related 7 homolog (S. cerevisiae).	0.812
LOC103359870	mocs3	ENSSPAP00000031020	ENSSPAP00000025637	Ubiquitin-like modifier activating enzyme 3.	Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...]	0.507
LOC103359870	nae1	ENSSPAP00000031020	ENSSPAP00000023489	Ubiquitin-like modifier activating enzyme 3.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.996
LOC103359870	sae1	ENSSPAP00000031020	ENSSPAP00000002914	Ubiquitin-like modifier activating enzyme 3.	SUMO1 activating enzyme subunit 1.	0.477
LOC103359870	uba1	ENSSPAP00000031020	ENSSPAP00000005618	Ubiquitin-like modifier activating enzyme 3.	Ubiquitin-like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	0.780
LOC103359870	uba5	ENSSPAP00000031020	ENSSPAP00000002015	Ubiquitin-like modifier activating enzyme 3.	Ubiquitin-like modifier activating enzyme 5.	0.799
LOC103359870	uba6	ENSSPAP00000031020	ENSSPAP00000028058	Ubiquitin-like modifier activating enzyme 3.	Ubiquitin like modifier activating enzyme 6.	0.780
LOC103360413	LOC103359870	ENSSPAP00000026212	ENSSPAP00000031020	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	Ubiquitin-like modifier activating enzyme 3.	0.780
LOC103360413	UBA3	ENSSPAP00000026212	ENSSPAP00000025309	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	Ubiquitin like modifier activating enzyme 3.	0.780
LOC103360413	atg7	ENSSPAP00000026212	ENSSPAP00000010802	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	ATG7 autophagy related 7 homolog (S. cerevisiae).	0.807
LOC103360413	mocs3	ENSSPAP00000026212	ENSSPAP00000025637	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...]	0.416
LOC103360413	nae1	ENSSPAP00000026212	ENSSPAP00000023489	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.419
LOC103360413	uba1	ENSSPAP00000026212	ENSSPAP00000005618	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	Ubiquitin-like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	0.900
LOC103360413	uba2	ENSSPAP00000026212	ENSSPAP00000009712	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.402
LOC103360413	uba5	ENSSPAP00000026212	ENSSPAP00000002015	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	Ubiquitin-like modifier activating enzyme 5.	0.780
LOC103360413	uba6	ENSSPAP00000026212	ENSSPAP00000028058	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	Ubiquitin like modifier activating enzyme 6.	0.901
UBA3	LOC103359870	ENSSPAP00000025309	ENSSPAP00000031020	Ubiquitin like modifier activating enzyme 3.	Ubiquitin-like modifier activating enzyme 3.	0.898
UBA3	LOC103360413	ENSSPAP00000025309	ENSSPAP00000026212	Ubiquitin like modifier activating enzyme 3.	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	0.780