STRINGSTRING
dbf4 dbf4 cdkn1b cdkn1b smc1a smc1a fbxw12 fbxw12 fam126b fam126b LOC103368183 LOC103368183 cdk7 cdk7 ccnd1 ccnd1 ccnb1 ccnb1 cdk4 cdk4 LOC103363259 LOC103363259 wee1 wee1 LOC103365420 LOC103365420 LOC103366935 LOC103366935 LOC103354552 LOC103354552 bub1 bub1 LOC103361111 LOC103361111 cdc45 cdc45 cdc7 cdc7 LOC103364889 LOC103364889 ccnh ccnh anapc10 anapc10 pcna pcna LOC103374507 LOC103374507 LOC103368869 LOC103368869 CCNE2 CCNE2 ccne1 ccne1 espl1 espl1 cdk2 cdk2 LOC103358269 LOC103358269 crebbp crebbp SMAD4 SMAD4 cdc23 cdc23 stag1 stag1 atr atr mcm7 mcm7 ENSSPAP00000003910 ENSSPAP00000003910 ENSSPAP00000003961 ENSSPAP00000003961 e2f1 e2f1 ywhaq ywhaq LOC103358853 LOC103358853 orc2 orc2 mcm2 mcm2 LOC103375195 LOC103375195 LOC103375192 LOC103375192 LOC103358868 LOC103358868 zbtb46 zbtb46 ENSSPAP00000004955 ENSSPAP00000004955 mcm5 mcm5 LOC103358884 LOC103358884 snapin snapin cdk1 cdk1 LOC103361063 LOC103361063 LOC103361651 LOC103361651 rb1 rb1 FZR1 FZR1 LOC103364951 LOC103364951 pkmyt1 pkmyt1 LOC103374609 LOC103374609 smc3 smc3 e2f4 e2f4 LOC103356710 LOC103356710 HDAC2 HDAC2 LOC103374064 LOC103374064 anapc13 anapc13 LOC103353415 LOC103353415 ENSSPAP00000007488 ENSSPAP00000007488 mad2l2 mad2l2 tmem82 tmem82 ccna2 ccna2 ENSSPAP00000008133 ENSSPAP00000008133 ENSSPAP00000008146 ENSSPAP00000008146 anapc2 anapc2 mcm6 mcm6 gadd45g gadd45g tfdp1 tfdp1 wee2 wee2 LOC103374198 LOC103374198 cdk20 cdk20 e2f3 e2f3 LOC103362885 LOC103362885 orc4 orc4 cdc16 cdc16 anapc7 anapc7 LOC103367780 LOC103367780 chek1 chek1 LOC103357720 LOC103357720 GADD45A GADD45A LOC103372307 LOC103372307 cdc20 cdc20 cdc14b cdc14b cdk6 cdk6 HDAC1 HDAC1 tgfb3 tgfb3 ENSSPAP00000012474 ENSSPAP00000012474 ENSSPAP00000012493 ENSSPAP00000012493 prkdc prkdc ENSSPAP00000013073 ENSSPAP00000013073 LOC103361725 LOC103361725 LOC103375280 LOC103375280 LOC103353173 LOC103353173 LOC103352981 LOC103352981 smad2 smad2 cdc6 cdc6 ENSSPAP00000014203 ENSSPAP00000014203 ENSSPAP00000014226 ENSSPAP00000014226 cdc26 cdc26 mad2l1 mad2l1 LOC103373063 LOC103373063 LOC103353832 LOC103353832 abl1 abl1 LOC103371563 LOC103371563 ENSSPAP00000030409 ENSSPAP00000030409 LOC103372710 LOC103372710 LOC103373263 LOC103373263 skp2 skp2 LOC103376275 LOC103376275 MYC MYC zbtb47 zbtb47 orc1 orc1 cdc27 cdc27 ccna1 ccna1 cdkn2d cdkn2d ENSSPAP00000016622 ENSSPAP00000016622 mad1l1 mad1l1 ENSSPAP00000017696 ENSSPAP00000017696 LOC103357941 LOC103357941 RAD21 RAD21 ENSSPAP00000018523 ENSSPAP00000018523 ENSSPAP00000018547 ENSSPAP00000018547 anapc4 anapc4 mdm2 mdm2 LOC103364795 LOC103364795 anapc5 anapc5 LOC103368661 LOC103368661 LOC103363570 LOC103363570 anapc11 anapc11 CDC25B CDC25B ap5s1 ap5s1 ENSSPAP00000020133 ENSSPAP00000020133 bub3 bub3 LOC103354693 LOC103354693 PLK1 PLK1 mcm4 mcm4 cntd2 cntd2 tgfb2 tgfb2 LOC103372062 LOC103372062 hdac8 hdac8 LOC103376074 LOC103376074 tp53 tp53 cul1 cul1 atm atm e2f2 e2f2 LOC103366989 LOC103366989 YWHAB YWHAB mynn mynn ep300 ep300 rbx1 rbx1 LOC103363683 LOC103363683 LOC103372520 LOC103372520 GADD45B GADD45B ENSSPAP00000024609 ENSSPAP00000024609 orc3 orc3 znf652 znf652 smad3 smad3 LOC103358709 LOC103358709 cdkn2c cdkn2c LOC103371434 LOC103371434 LOC103354810 LOC103354810 orc5 orc5 LOC103353199 LOC103353199 anapc1 anapc1 ttk ttk ccnd2 ccnd2 ccnb3 ccnb3 GADD45B-2 GADD45B-2 zbtb10 zbtb10 mcm3 mcm3 skp1 skp1 gsk3b gsk3b bub1b bub1b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dbf4DBF4 zinc finger. (627 aa)
cdkn1bCyclin-dependent kinase inhibitor 1Bb. (186 aa)
smc1aStructural maintenance of chromosomes protein. (1231 aa)
fbxw12Si:ch73-142c19.1. (469 aa)
fam126bZgc:158316. (512 aa)
LOC103368183Cyclin Dx; Belongs to the cyclin family. (311 aa)
cdk7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (343 aa)
ccnd1Cyclin D1; Belongs to the cyclin family. (292 aa)
ccnb1Cyclin B1; Belongs to the cyclin family. (411 aa)
cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (306 aa)
LOC103363259Stromal antigen 2a. (1275 aa)
wee1Wee1-like protein kinase. (620 aa)
LOC10336542014_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa)
LOC103366935Structural maintenance of chromosomes protein. (1245 aa)
LOC103354552Growth arrest and DNA-damage-inducible, alpha, a. (166 aa)
bub1Uncharacterized protein. (1261 aa)
LOC103361111Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (124 aa)
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae). (568 aa)
cdc7Cell division cycle 7 homolog (S. cerevisiae). (617 aa)
LOC10336488914_3_3 domain-containing protein; Belongs to the 14-3-3 family. (244 aa)
ccnhCyclin H; Belongs to the cyclin family. (319 aa)
anapc10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (186 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
LOC103374507Mothers against decapentaplegic homolog. (472 aa)
LOC103368869Cyclin B2; Belongs to the cyclin family. (388 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (362 aa)
ccne1Cyclin E1; Belongs to the cyclin family. (433 aa)
espl1Extra spindle pole bodies like 1, separase. (2157 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
LOC103358269Cyclin E2; Belongs to the cyclin family. (383 aa)
crebbpCREB binding protein a. (2386 aa)
SMAD4Mothers against decapentaplegic homolog. (528 aa)
cdc23CDC23 (cell division cycle 23, yeast, homolog). (605 aa)
stag1Stromal antigen 1a. (1260 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2496 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (727 aa)
ENSSPAP00000003910SCD domain-containing protein. (108 aa)
ENSSPAP00000003961STAG domain-containing protein. (213 aa)
e2f1E2F transcription factor 1. (471 aa)
ywhaq14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (249 aa)
LOC103358853Cyclin-dependent kinase inhibitor 1Cb. (216 aa)
orc2Origin recognition complex, subunit 2. (580 aa)
mcm2DNA helicase; Belongs to the MCM family. (890 aa)
LOC103375195Retinoblastoma-like 1 (p107). (506 aa)
LOC103375192IF rod domain-containing protein; Belongs to the intermediate filament family. (447 aa)
LOC103358868Myelocytomatosis oncogene homolog. (371 aa)
zbtb46Zinc finger and BTB domain containing 46. (616 aa)
ENSSPAP00000004955Cyclin-dependent kinase 21; Belongs to the protein kinase superfamily. (188 aa)
mcm5DNA helicase; Belongs to the MCM family. (737 aa)
LOC103358884Mothers against decapentaplegic homolog. (651 aa)
snapinSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (129 aa)
cdk1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (303 aa)
LOC103361063Mothers against decapentaplegic homolog. (467 aa)
LOC103361651Mothers against decapentaplegic homolog. (503 aa)
rb1Retinoblastoma 1. (909 aa)
FZR1Fizzy/cell division cycle 20 related 1a. (496 aa)
LOC103364951Fizzy/cell division cycle 20 related 1b. (519 aa)
pkmyt1Protein kinase, membrane associated tyrosine/threonine 1. (583 aa)
LOC103374609Uncharacterized protein; Belongs to the cyclin family. (278 aa)
smc3Structural maintenance of chromosomes protein. (1217 aa)
e2f4E2F transcription factor 4. (390 aa)
LOC1033567103-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2; Belongs to the 14-3-3 family. (247 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (490 aa)
LOC103374064Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (296 aa)
anapc13Anaphase promoting complex subunit 13. (74 aa)
LOC103353415Ribosomal_L7Ae domain-containing protein. (149 aa)
ENSSPAP00000007488Growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1. (203 aa)
mad2l2Mitotic arrest deficient 2 like 2. (210 aa)
tmem82Transmembrane protein 82. (348 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (436 aa)
ENSSPAP00000008133BTB domain-containing protein. (70 aa)
ENSSPAP00000008146Uncharacterized protein. (230 aa)
anapc2Anaphase promoting complex subunit 2; Belongs to the cullin family. (778 aa)
mcm6DNA helicase; Belongs to the MCM family. (834 aa)
gadd45gGrowth arrest and DNA-damage-inducible, gamma a. (159 aa)
tfdp1Transcription factor. (413 aa)
wee2Wee1-like protein kinase. (534 aa)
LOC103374198Transforming growth factor beta; Belongs to the TGF-beta family. (422 aa)
cdk20Cyclin-dependent kinase 20. (238 aa)
e2f3E2F transcription factor 3. (444 aa)
LOC103362885Cyclin-dependent kinase inhibitor 1A. (170 aa)
orc4Origin recognition complex, subunit 4. (297 aa)
cdc16Cell division cycle 16 homolog (S. cerevisiae). (619 aa)
anapc7Anaphase promoting complex subunit 7. (565 aa)
LOC103367780Cell division cycle 14Ab. (585 aa)
chek1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (457 aa)
LOC103357720Si:ch211-269e2.1. (1183 aa)
GADD45AGrowth arrest and DNA-damage-inducible, alpha, b. (154 aa)
LOC103372307Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (479 aa)
cdc20Cell division cycle 20 homolog. (502 aa)
cdc14bUncharacterized protein. (553 aa)
cdk6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (328 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (490 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (405 aa)
ENSSPAP00000012474E2F_TDP domain-containing protein. (127 aa)
ENSSPAP00000012493Uncharacterized protein. (125 aa)
prkdcProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3883 aa)
ENSSPAP00000013073Syntaphilin b. (480 aa)
LOC103361725Uncharacterized protein. (173 aa)
LOC103375280Transforming growth factor beta; Belongs to the TGF-beta family. (333 aa)
LOC103353173Uncharacterized protein. (183 aa)
LOC103352981Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (370 aa)
smad2Mothers against decapentaplegic homolog. (470 aa)
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (558 aa)
ENSSPAP00000014203E2F_TDP domain-containing protein. (238 aa)
ENSSPAP00000014226Uncharacterized protein. (401 aa)
cdc26Cell division cycle 26 homolog. (97 aa)
mad2l1MAD2 mitotic arrest deficient-like 1 (yeast). (204 aa)
LOC103373063Uncharacterized protein. (477 aa)
LOC103353832RAD21 cohesin complex component a. (632 aa)
abl1Tyrosine-protein kinase. (1119 aa)
LOC103371563E1A binding protein p300 a. (2869 aa)
ENSSPAP00000030409Uncharacterized protein. (174 aa)
LOC103372710Retinoblastoma-like 2 (p130). (881 aa)
LOC103373263Transforming growth factor beta; Belongs to the TGF-beta family. (384 aa)
skp2S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (433 aa)
LOC103376275Transcriptional regulator Myc-like. (438 aa)
MYCTranscriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
zbtb47Zinc finger and BTB domain containing 47b. (743 aa)
orc1Origin recognition complex, subunit 1. (835 aa)
cdc27Cell division cycle 27. (803 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (398 aa)
cdkn2dCyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4). (164 aa)
ENSSPAP00000016622Transmembrane protein 82. (300 aa)
mad1l1Mitotic arrest deficient 1 like 1. (707 aa)
ENSSPAP00000017696Cyclin D3; Belongs to the cyclin family. (216 aa)
LOC103357941Cyclin-dependent kinase inhibitor 1-like. (170 aa)
RAD21RAD21 cohesin complex component. (624 aa)
ENSSPAP00000018523E2F transcription factor 5. (144 aa)
ENSSPAP00000018547E2F transcription factor 5. (148 aa)
anapc4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (805 aa)
mdm2MDM2 proto-oncogene. (514 aa)
LOC10336479514_3_3 domain-containing protein; Belongs to the 14-3-3 family. (248 aa)
anapc5Anaphase promoting complex subunit 5. (773 aa)
LOC103368661Uncharacterized protein. (507 aa)
LOC103363570Transforming growth factor beta; Belongs to the TGF-beta family. (408 aa)
anapc11APC11 anaphase promoting complex subunit 11 homolog (yeast). (84 aa)
CDC25BCell division cycle 25B. (573 aa)
ap5s1Adaptor related protein complex 5 subunit sigma 1. (200 aa)
ENSSPAP00000020133Rad21_Rec8_N domain-containing protein. (154 aa)
bub3BUB3 mitotic checkpoint protein. (326 aa)
LOC103354693Stromal antigen 2b. (1272 aa)
PLK1Serine/threonine-protein kinase PLK. (579 aa)
mcm4DNA helicase; Belongs to the MCM family. (860 aa)
cntd2Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (388 aa)
tgfb2Transforming growth factor, beta 2. (144 aa)
LOC103372062Cyclin-dependent kinase inhibitor 1D. (188 aa)
hdac8Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (400 aa)
LOC103376074Cyclin D2, a; Belongs to the cyclin family. (383 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
cul1Cullin 1b; Belongs to the cullin family. (776 aa)
atmNon-specific serine/threonine protein kinase. (3048 aa)
e2f2Si:ch211-160f23.5. (447 aa)
LOC103366989Uncharacterized protein. (187 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b; Belongs to the 14-3-3 family. (244 aa)
mynnMyoneurin. (793 aa)
ep300E1A binding protein p300 b. (2872 aa)
rbx1Ring-box 1, E3 ubiquitin protein ligase. (146 aa)
LOC1033636833-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1; Belongs to the 14-3-3 family. (247 aa)
LOC103372520WD_REPEATS_REGION domain-containing protein. (495 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (170 aa)
ENSSPAP0000002460914_3_3 domain-containing protein; Belongs to the 14-3-3 family. (198 aa)
orc3Origin recognition complex, subunit 3. (721 aa)
znf652Zinc finger protein 652. (674 aa)
smad3Mothers against decapentaplegic homolog. (425 aa)
LOC103358709CREB binding protein b. (2452 aa)
cdkn2cCyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4). (164 aa)
LOC103371434Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; Belongs to the 14-3-3 family. (353 aa)
LOC10335481014_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa)
orc5Origin recognition complex, subunit 5. (445 aa)
LOC103353199Mothers against decapentaplegic homolog. (425 aa)
anapc1Anaphase promoting complex subunit 1. (1982 aa)
ttkTtk protein kinase. (998 aa)
ccnd2Cyclin D2, b; Belongs to the cyclin family. (294 aa)
ccnb3Cyclin B3; Belongs to the cyclin family. (427 aa)
GADD45B-2Growth arrest and DNA damage inducible beta. (160 aa)
zbtb10Zinc finger and BTB domain containing 10. (592 aa)
mcm3DNA helicase; Belongs to the MCM family. (815 aa)
skp1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
gsk3bGlycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. (399 aa)
bub1bBUB1 mitotic checkpoint serine/threonine kinase Bb. (411 aa)
Your Current Organism:
Stegastes partitus
NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish
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