STRINGSTRING
ccnd2 ccnd2 STEAP3 STEAP3 LOC103371019 LOC103371019 LOC103363124 LOC103363124 bcl2 bcl2 ENSSPAP00000030409 ENSSPAP00000030409 LOC103353268 LOC103353268 LOC103371515 LOC103371515 ccnb1 ccnb1 ccnd1 ccnd1 LOC103357552 LOC103357552 ei24 ei24 LOC103368183 LOC103368183 LOC103353806 LOC103353806 LOC103365897 LOC103365897 LOC103367645 LOC103367645 LOC103376203 LOC103376203 hps5 hps5 steap2 steap2 DDB2 DDB2 LOC103357505 LOC103357505 siva1 siva1 GADD45B-2 GADD45B-2 tp73 tp73 LOC103371613 LOC103371613 TP53I3 TP53I3 ENSSPAP00000024086 ENSSPAP00000024086 GADD45B GADD45B LOC103363676 LOC103363676 LOC103370384 LOC103370384 atm atm tp53 tp53 sesn2 sesn2 LOC103376074 LOC103376074 LOC103372062 LOC103372062 LOC103361889 LOC103361889 LOC103366492 LOC103366492 cntd2 cntd2 thbs1 thbs1 LOC103360880 LOC103360880 LOC103360879 LOC103360879 LOC103376010 LOC103376010 mdm2 mdm2 LOC103355222 LOC103355222 LOC103364622 LOC103364622 perp perp adgrb2 adgrb2 LOC103357941 LOC103357941 ENSSPAP00000017696 ENSSPAP00000017696 LOC103370277 LOC103370277 cenpu cenpu LOC103373595 LOC103373595 ENSSPAP00000016593 ENSSPAP00000016593 apaf1 apaf1 ccng1 ccng1 ddb2 ddb2 bax bax LOC103371250 LOC103371250 zmat3 zmat3 cop1 cop1 mdm4 mdm4 LOC103373540 LOC103373540 cdk6 cdk6 LOC103367815 LOC103367815 siah1 siah1 LOC103354568 LOC103354568 LOC103375901 LOC103375901 GADD45A GADD45A gorab gorab tsc2 tsc2 serpine1 serpine1 aifm2 aifm2 chek1 chek1 adgrb3 adgrb3 CCNG2 CCNG2 LOC103362885 LOC103362885 LOC103365021 LOC103365021 ppm1d ppm1d LOC103374023 LOC103374023 CRYZ CRYZ LOC103365576 LOC103365576 LOC103371151 LOC103371151 gadd45g gadd45g LOC103368447 LOC103368447 ENSSPAP00000007488 ENSSPAP00000007488 LOC103353415 LOC103353415 rprm rprm LOC103358919 LOC103358919 LOC103374064 LOC103374064 casp9 casp9 LOC103374609 LOC103374609 fam76b fam76b rchy1 rchy1 siah2 siah2 LOC103354477 LOC103354477 cdk1 cdk1 LOC103356497 LOC103356497 ENSSPAP00000004955 ENSSPAP00000004955 igf1 igf1 sesn1 sesn1 atr atr LOC103358269 LOC103358269 cdk2 cdk2 ccne1 ccne1 CCNE2 CCNE2 LOC103375119 LOC103375119 LOC103368869 LOC103368869 LOC103375115 LOC103375115 bcl2l1 bcl2l1 PTEN PTEN LOC103354552 LOC103354552 adgrb1 adgrb1 cdk4 cdk4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ccnd2Cyclin D2, b; Belongs to the cyclin family. (294 aa)
STEAP3STEAP3 metalloreductase. (491 aa)
LOC103371019Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
LOC103363124Thrombospondin 1a. (1173 aa)
bcl2BCL2 apoptosis regulator b. (228 aa)
ENSSPAP00000030409Uncharacterized protein. (174 aa)
LOC103353268Tumor necrosis factor receptor superfamily, member a. (448 aa)
LOC103371515Uncharacterized protein. (492 aa)
ccnb1Cyclin B1; Belongs to the cyclin family. (411 aa)
ccnd1Cyclin D1; Belongs to the cyclin family. (292 aa)
LOC103357552Zgc:153993. (205 aa)
ei24EI24 autophagy associated transmembrane protein. (340 aa)
LOC103368183Cyclin Dx; Belongs to the cyclin family. (311 aa)
LOC103353806Uncharacterized protein. (416 aa)
LOC103365897BH4_2 domain-containing protein. (211 aa)
LOC103367645IlGF domain-containing protein. (184 aa)
LOC103376203Caspase 10, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (549 aa)
hps5Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. (1113 aa)
steap2STEAP family member 2, metalloreductase. (499 aa)
DDB2DNA damage-binding protein 2-like. (496 aa)
LOC103357505Uncharacterized protein. (224 aa)
siva1Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (173 aa)
GADD45B-2Growth arrest and DNA damage inducible beta. (160 aa)
tp73Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (622 aa)
LOC103371613Ribonucleotide reductase M2 b. (288 aa)
TP53I3Tumor protein p53 inducible protein 3. (333 aa)
ENSSPAP00000024086BH4_2 domain-containing protein. (205 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (170 aa)
LOC103363676Tetraspanin. (314 aa)
LOC103370384Protein phosphatase, Mg2+/Mn2+ dependent, 1Db. (571 aa)
atmNon-specific serine/threonine protein kinase. (3048 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
sesn2Sestrin 2. (444 aa)
LOC103376074Cyclin D2, a; Belongs to the cyclin family. (383 aa)
LOC103372062Cyclin-dependent kinase inhibitor 1D. (188 aa)
LOC103361889Tetraspanin. (255 aa)
LOC103366492Reprimo-like. (107 aa)
cntd2Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (388 aa)
thbs1Thrombospondin 1b. (1169 aa)
LOC103360880Uncharacterized protein. (330 aa)
LOC103360879Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (445 aa)
LOC103376010P53-induced death domain protein 1. (884 aa)
mdm2MDM2 proto-oncogene. (514 aa)
LOC103355222Tetraspanin. (256 aa)
LOC103364622Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (107 aa)
perpP53 apoptosis effector related to pmp22. (184 aa)
adgrb2Adhesion G protein-coupled receptor B2; Belongs to the G-protein coupled receptor 2 family. (1380 aa)
LOC103357941Cyclin-dependent kinase inhibitor 1-like. (170 aa)
ENSSPAP00000017696Cyclin D3; Belongs to the cyclin family. (216 aa)
LOC103370277Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (282 aa)
cenpuUncharacterized protein. (386 aa)
LOC103373595Caspase 3; Belongs to the peptidase C14A family. (297 aa)
ENSSPAP00000016593Uncharacterized protein. (417 aa)
apaf1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1258 aa)
ccng1Cyclin G1; Belongs to the cyclin family. (299 aa)
ddb2Damage-specific DNA-binding protein 2. (496 aa)
baxBCL2 associated X, apoptosis regulator a. (192 aa)
LOC103371250Uncharacterized protein. (201 aa)
zmat3Zinc finger, matrin-type 3. (311 aa)
cop1COP1 E3 ubiquitin ligase. (717 aa)
mdm4MDM4 regulator of p53; Belongs to the MDM2/MDM4 family. (489 aa)
LOC103373540Uncharacterized protein; Belongs to the peptidase C14A family. (288 aa)
cdk6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (328 aa)
LOC103367815Cyclin G2; Belongs to the cyclin family. (334 aa)
siah1E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (341 aa)
LOC103354568GTSE1_N domain-containing protein. (717 aa)
LOC103375901Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
GADD45AGrowth arrest and DNA-damage-inducible, alpha, b. (154 aa)
gorabGolgin, rab6-interacting. (375 aa)
tsc2TSC complex subunit 2. (1692 aa)
serpine1Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (388 aa)
aifm2Apoptosis inducing factor mitochondria associated 2. (372 aa)
chek1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (457 aa)
adgrb3Adhesion G protein-coupled receptor B3; Belongs to the G-protein coupled receptor 2 family. (1531 aa)
CCNG2Cyclin G2; Belongs to the cyclin family. (334 aa)
LOC103362885Cyclin-dependent kinase inhibitor 1A. (170 aa)
LOC103365021BH3 interacting domain death agonist. (200 aa)
ppm1dProtein phosphatase, Mg2+/Mn2+ dependent, 1Da. (539 aa)
LOC103374023Si:zfos-80g12.1. (444 aa)
CRYZCrystallin zeta. (219 aa)
LOC103365576Crystallin, zeta (quinone reductase). (327 aa)
LOC103371151Insulin like growth factor binding protein 3. (295 aa)
gadd45gGrowth arrest and DNA-damage-inducible, gamma a. (159 aa)
LOC103368447STEAP family member 3, metalloreductase. (492 aa)
ENSSPAP00000007488Growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1. (203 aa)
LOC103353415Ribosomal_L7Ae domain-containing protein. (149 aa)
rprmReprimo, TP53 dependent G2 arrest mediator candidate b. (102 aa)
LOC103358919Insulin-like growth factor binding protein 3. (285 aa)
LOC103374064Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (296 aa)
casp9Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (432 aa)
LOC103374609Uncharacterized protein; Belongs to the cyclin family. (278 aa)
fam76bFamily with sequence similarity 76 member B. (334 aa)
rchy1Uncharacterized protein. (277 aa)
siah2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (332 aa)
LOC103354477Transmembrane phosphatase with tensin homology. (512 aa)
cdk1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (303 aa)
LOC103356497Adhesion G protein-coupled receptor B1b; Belongs to the G-protein coupled receptor 2 family. (1114 aa)
ENSSPAP00000004955Cyclin-dependent kinase 21; Belongs to the protein kinase superfamily. (188 aa)
igf1Insulin-like growth factor 1. (185 aa)
sesn1Sestrin 1. (547 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2496 aa)
LOC103358269Cyclin E2; Belongs to the cyclin family. (383 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
ccne1Cyclin E1; Belongs to the cyclin family. (433 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (362 aa)
LOC103375119Uncharacterized protein; Belongs to the peptidase C14A family. (295 aa)
LOC103368869Cyclin B2; Belongs to the cyclin family. (388 aa)
LOC103375115Uncharacterized protein; Belongs to the peptidase C14A family. (497 aa)
bcl2l1BCL2 like 1. (229 aa)
PTENPhosphatase and tensin homolog B. (278 aa)
LOC103354552Growth arrest and DNA-damage-inducible, alpha, a. (166 aa)
adgrb1Adhesion G protein-coupled receptor B1a; Belongs to the G-protein coupled receptor 2 family. (1534 aa)
cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (306 aa)
Your Current Organism:
Stegastes partitus
NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish
Server load: low (22%) [HD]