(54 nodes) Cytosolic DNA-sensing pathway network (Stegastes partitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	polr3k	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (108 aa)
	nfkb1	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (929 aa)
	ENSSPAP00000031224	SCY domain-containing protein. (91 aa)
	polr3d	Polymerase (RNA) III (DNA directed) polypeptide D. (386 aa)
	sting1	Transmembrane protein 173. (408 aa)
	polr3c	RNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (548 aa)
	adar	Adenosine deaminase RNA specific. (1338 aa)
	polr3e	Polymerase (RNA) III (DNA directed) polypeptide E. (689 aa)
	polr1c	RNA polymerase I and III subunit C. (351 aa)
	LOC103368198	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (439 aa)
	piwil2	Piwi-like RNA-mediated gene silencing 2; Belongs to the argonaute family. (886 aa)
	polr2f	Polymerase (RNA) II (DNA directed) polypeptide F. (144 aa)
	polr2k	Uncharacterized protein. (59 aa)
	ENSSPAP00000025562	Polymerase (RNA) II (DNA directed) polypeptide L. (67 aa)
	polr3h	Polymerase (RNA) III (DNA directed) polypeptide H. (214 aa)
	polr3a	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1402 aa)
	POLR2E	RNA polymerase II subunit E. (210 aa)
	pycard	PYD and CARD domain containing. (201 aa)
	ENSSPAP00000019954	Uncharacterized protein. (185 aa)
	mavs	CARD_2 domain-containing protein. (561 aa)
	LOC103371285	Uncharacterized protein. (274 aa)
	polr2h	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
	LOC103358516	SCY domain-containing protein. (119 aa)
	LOC103366847	RNA polymerase I and III subunit D. (114 aa)
	LOC103370779	Uncharacterized protein. (184 aa)
	ENSSPAP00000015538	Uncharacterized protein. (216 aa)
	LOC103362339	Interleukin-1. (247 aa)
	ikbke	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (721 aa)
	ENSSPAP00000014743	Receptor-interacting serine-threonine kinase 3. (328 aa)
	polr3gl	DNA-directed RNA polymerase III subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. (222 aa)
	LOC103375302	Zgc:171971. (362 aa)
	LOC103357826	Caspase a; Belongs to the peptidase C14A family. (387 aa)
	REL	REL proto-oncogene, NF-kB subunit. (639 aa)
	ENSSPAP00000011783	Polymerase (RNA) III (DNA directed) polypeptide B. (403 aa)
	ENSSPAP00000011748	Polymerase (RNA) III (DNA directed) polypeptide B. (340 aa)
	ikbkb	Inhibitor of nuclear factor kappa B kinase subunit beta. (685 aa)
	irf7	Interferon regulatory factor 7. (437 aa)
	ifna21	Uncharacterized protein. (160 aa)
	rela	V-rel avian reticuloendotheliosis viral oncogene homolog A. (634 aa)
	LOC103369011	Component of inhibitor of nuclear factor kappa B kinase complex. (735 aa)
	cgas	Cyclic GMP-AMP synthase. (565 aa)
	LOC103358935	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (307 aa)
	LOC103371785	Uncharacterized protein. (226 aa)
	irf3	Interferon regulatory factor 3. (463 aa)
	ripk1	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like. (687 aa)
	ENSSPAP00000005790	Protein kinase domain-containing protein. (138 aa)
	polr3g	DNA-directed RNA polymerase III subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. (214 aa)
	LOC103374020	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (463 aa)
	ENSSPAP00000002820	Uncharacterized protein. (45 aa)
	polr3f	DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. (290 aa)
	LOC103365446	Mab-21 domain-containing protein. (487 aa)
	nfkbia	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (318 aa)
	LOC103366020	Protein kinase domain-containing protein. (762 aa)
	ENSSPAP00000000093	SCY domain-containing protein. (112 aa)

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSPAP00000002820	ENSSPAP00000005790	ENSSPAP00000002820	ENSSPAP00000005790	Uncharacterized protein.	Protein kinase domain-containing protein.	0.433
ENSSPAP00000002820	ENSSPAP00000014743	ENSSPAP00000002820	ENSSPAP00000014743	Uncharacterized protein.	Receptor-interacting serine-threonine kinase 3.	0.623
ENSSPAP00000002820	LOC103357826	ENSSPAP00000002820	ENSSPAP00000012039	Uncharacterized protein.	Caspase a; Belongs to the peptidase C14A family.	0.425
ENSSPAP00000002820	LOC103358935	ENSSPAP00000002820	ENSSPAP00000008419	Uncharacterized protein.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	0.971
ENSSPAP00000002820	LOC103362339	ENSSPAP00000002820	ENSSPAP00000015284	Uncharacterized protein.	Interleukin-1.	0.440
ENSSPAP00000002820	LOC103366020	ENSSPAP00000002820	ENSSPAP00000000820	Uncharacterized protein.	Protein kinase domain-containing protein.	0.869
ENSSPAP00000002820	LOC103368198	ENSSPAP00000002820	ENSSPAP00000029165	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.623
ENSSPAP00000002820	LOC103374020	ENSSPAP00000002820	ENSSPAP00000005669	Uncharacterized protein.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.951
ENSSPAP00000002820	REL	ENSSPAP00000002820	ENSSPAP00000011812	Uncharacterized protein.	REL proto-oncogene, NF-kB subunit.	0.790
ENSSPAP00000002820	ikbke	ENSSPAP00000002820	ENSSPAP00000015109	Uncharacterized protein.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.433
ENSSPAP00000002820	irf3	ENSSPAP00000002820	ENSSPAP00000008064	Uncharacterized protein.	Interferon regulatory factor 3.	0.557
ENSSPAP00000002820	irf7	ENSSPAP00000002820	ENSSPAP00000009832	Uncharacterized protein.	Interferon regulatory factor 7.	0.871
ENSSPAP00000002820	mavs	ENSSPAP00000002820	ENSSPAP00000019466	Uncharacterized protein.	CARD_2 domain-containing protein.	0.860
ENSSPAP00000002820	nfkb1	ENSSPAP00000002820	ENSSPAP00000031292	Uncharacterized protein.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1.	0.915
ENSSPAP00000002820	nfkbia	ENSSPAP00000002820	ENSSPAP00000001253	Uncharacterized protein.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b.	0.971
ENSSPAP00000002820	rela	ENSSPAP00000002820	ENSSPAP00000009512	Uncharacterized protein.	V-rel avian reticuloendotheliosis viral oncogene homolog A.	0.790
ENSSPAP00000002820	ripk1	ENSSPAP00000002820	ENSSPAP00000006343	Uncharacterized protein.	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.	0.927
ENSSPAP00000002820	sting1	ENSSPAP00000002820	ENSSPAP00000030307	Uncharacterized protein.	Transmembrane protein 173.	0.901
ENSSPAP00000005790	ENSSPAP00000002820	ENSSPAP00000005790	ENSSPAP00000002820	Protein kinase domain-containing protein.	Uncharacterized protein.	0.433
ENSSPAP00000005790	ENSSPAP00000014743	ENSSPAP00000005790	ENSSPAP00000014743	Protein kinase domain-containing protein.	Receptor-interacting serine-threonine kinase 3.	0.562