(10 nodes) Fanconi Anemia Pathway network (Fonsecaea pedrosoi)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Z517_00892	Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence; Belongs to the PI3/PI4-kinase family. (2298 aa)
	Z517_06716	Unplaced genomic scaffold supercont1.4, whole genome shotgun sequence. (569 aa)
	Z517_00961	Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence. (240 aa)
	Z517_00960	Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence. (277 aa)
	Z517_09243	Unplaced genomic scaffold supercont1.6, whole genome shotgun sequence. (559 aa)
	Z517_12078	Unplaced genomic scaffold supercont1.8, whole genome shotgun sequence. (154 aa)
	Z517_02638	Unplaced genomic scaffold supercont1.2, whole genome shotgun sequence. (878 aa)
	Z517_02633	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (936 aa)
	Z517_08345	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (606 aa)
	SLX1	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (420 aa)

Your Current Organism:

Fonsecaea pedrosoi

NCBI taxonomy Id: 1442368
Other names: F. pedrosoi CBS 271.37, Fonsecaea pedrosoi CBS 271.37

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SLX1	Z517_00892	A0A0D2F0A9	A0A0D2E654	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence; Belongs to the PI3/PI4-kinase family.	0.463
SLX1	Z517_02633	A0A0D2F0A9	A0A0D2GQX7	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.	0.810
SLX1	Z517_02638	A0A0D2F0A9	A0A0D2GQY3	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	Unplaced genomic scaffold supercont1.2, whole genome shotgun sequence.	0.694
SLX1	Z517_06716	A0A0D2F0A9	A0A0D2DQN6	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	Unplaced genomic scaffold supercont1.4, whole genome shotgun sequence.	0.981
Z517_00892	SLX1	A0A0D2E654	A0A0D2F0A9	Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence; Belongs to the PI3/PI4-kinase family.	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	0.463
Z517_00892	Z517_08345	A0A0D2E654	A0A0D2GCU2	Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence; Belongs to the PI3/PI4-kinase family.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.982
Z517_00960	Z517_00961	A0A0D2GX33	A0A0D2HM98	Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence.	Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence.	0.556
Z517_00960	Z517_02633	A0A0D2GX33	A0A0D2GQX7	Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence.	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.	0.563
Z517_00960	Z517_02638	A0A0D2GX33	A0A0D2GQY3	Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence.	Unplaced genomic scaffold supercont1.2, whole genome shotgun sequence.	0.566
Z517_00960	Z517_06716	A0A0D2GX33	A0A0D2DQN6	Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence.	Unplaced genomic scaffold supercont1.4, whole genome shotgun sequence.	0.561
Z517_00960	Z517_08345	A0A0D2GX33	A0A0D2GCU2	Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.623
Z517_00961	Z517_00960	A0A0D2HM98	A0A0D2GX33	Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence.	Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence.	0.556
Z517_00961	Z517_02633	A0A0D2HM98	A0A0D2GQX7	Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence.	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.	0.563
Z517_00961	Z517_02638	A0A0D2HM98	A0A0D2GQY3	Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence.	Unplaced genomic scaffold supercont1.2, whole genome shotgun sequence.	0.566
Z517_00961	Z517_06716	A0A0D2HM98	A0A0D2DQN6	Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence.	Unplaced genomic scaffold supercont1.4, whole genome shotgun sequence.	0.561
Z517_00961	Z517_08345	A0A0D2HM98	A0A0D2GCU2	Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.623
Z517_02633	SLX1	A0A0D2GQX7	A0A0D2F0A9	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	0.810
Z517_02633	Z517_00960	A0A0D2GQX7	A0A0D2GX33	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.	Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence.	0.563
Z517_02633	Z517_00961	A0A0D2GQX7	A0A0D2HM98	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.	Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence.	0.563
Z517_02633	Z517_02638	A0A0D2GQX7	A0A0D2GQY3	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.	Unplaced genomic scaffold supercont1.2, whole genome shotgun sequence.	0.799