(5 nodes) Isopentenyl diphosphate biosynthetic process, mevalonate pathway, and Sterol-sensing domain network (Rhinocladiella mackenziei)

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Your Input:
	Z518_05140	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (477 aa)
	Z518_05483	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family. (399 aa)
	Z518_04544	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (484 aa)
	Z518_02850	3-hydroxy-3-methylglutaryl coenzyme A reductase. (1155 aa)
	Z518_02942	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (471 aa)

Your Current Organism:

Rhinocladiella mackenziei

NCBI taxonomy Id: 1442369
Other names: R. mackenziei CBS 650.93, Rhinocladiella mackenziei CBS 650.93

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Z518_02850	Z518_02942	A0A0D2IQH6	A0A0D2IY05	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.993
Z518_02850	Z518_04544	A0A0D2IQH6	A0A0D2H830	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.931
Z518_02850	Z518_05140	A0A0D2IQH6	A0A0D2H1E1	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.651
Z518_02850	Z518_05483	A0A0D2IQH6	A0A0D2H2G5	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family.	0.909
Z518_02942	Z518_02850	A0A0D2IY05	A0A0D2IQH6	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.993
Z518_02942	Z518_04544	A0A0D2IY05	A0A0D2H830	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.925
Z518_02942	Z518_05140	A0A0D2IY05	A0A0D2H1E1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.540
Z518_02942	Z518_05483	A0A0D2IY05	A0A0D2H2G5	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family.	0.876
Z518_04544	Z518_02850	A0A0D2H830	A0A0D2IQH6	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.931
Z518_04544	Z518_02942	A0A0D2H830	A0A0D2IY05	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.925
Z518_04544	Z518_05140	A0A0D2H830	A0A0D2H1E1	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.904
Z518_04544	Z518_05483	A0A0D2H830	A0A0D2H2G5	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family.	0.992
Z518_05140	Z518_02850	A0A0D2H1E1	A0A0D2IQH6	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.651
Z518_05140	Z518_02942	A0A0D2H1E1	A0A0D2IY05	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.540
Z518_05140	Z518_04544	A0A0D2H1E1	A0A0D2H830	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.904
Z518_05140	Z518_05483	A0A0D2H1E1	A0A0D2H2G5	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family.	0.918
Z518_05483	Z518_02850	A0A0D2H2G5	A0A0D2IQH6	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.909
Z518_05483	Z518_02942	A0A0D2H2G5	A0A0D2IY05	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.876
Z518_05483	Z518_04544	A0A0D2H2G5	A0A0D2H830	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.992
Z518_05483	Z518_05140	A0A0D2H2G5	A0A0D2H1E1	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family.	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.918