(62 nodes) Negative regulation of cell cycle process network (Rhinocladiella mackenziei)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Z518_09037	annotation not available (634 aa)
	Z518_07534	annotation not available (361 aa)
	Z518_09383	annotation not available (148 aa)
	Z518_09524	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (324 aa)
	Z518_08473	Chromosome segregation in meiosis protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (495 aa)
	Z518_08518	annotation not available (714 aa)
	Z518_05194	annotation not available (348 aa)
	Z518_03906	annotation not available (523 aa)
	Z518_02918	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. (539 aa)
	Z518_03233	Serine/threonine-protein phosphatase. (443 aa)
	Z518_00025	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (710 aa)
	Z518_00456	annotation not available (648 aa)
	Z518_10940	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (753 aa)
	Z518_10970	annotation not available (663 aa)
	Z518_10432	annotation not available (687 aa)
	Z518_10542	annotation not available (835 aa)
	Z518_09038	annotation not available (472 aa)
	Z518_09434	annotation not available (847 aa)
	Z518_07917	annotation not available (621 aa)
	Z518_06628	annotation not available (616 aa)
	Z518_06910	annotation not available (763 aa)
	Z518_07061	annotation not available (356 aa)
	Z518_07491	annotation not available (766 aa)
	Z518_03987	annotation not available (278 aa)
	Z518_05100	Cell division control protein; Belongs to the CDC6/cdc18 family. (626 aa)
	Z518_02337	annotation not available (611 aa)
	Z518_02487	annotation not available (539 aa)
	Z518_11361	annotation not available (1024 aa)
	Z518_10731	annotation not available (525 aa)
	Z518_10594	annotation not available (1740 aa)
	Z518_09914	annotation not available (1385 aa)
	Z518_08203	Protein phosphatase PP2A regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (477 aa)
	Z518_08581	Structural maintenance of chromosomes protein. (1183 aa)
	Z518_09761	annotation not available (226 aa)
	Z518_09796	annotation not available (481 aa)
	Z518_09031	annotation not available (766 aa)
	Z518_08145	Belongs to the protein kinase superfamily. (425 aa)
	Z518_06146	annotation not available (540 aa)
	Z518_06316	annotation not available (653 aa)
	Z518_04455	RNA-dependent RNA polymerase. (1397 aa)
	Z518_04475	annotation not available (1406 aa)
	Z518_07775	annotation not available (697 aa)
	Z518_02473	annotation not available (367 aa)
	Z518_02528	annotation not available (379 aa)
	Z518_03678	annotation not available (1713 aa)
	Z518_03885	annotation not available (903 aa)
	Z518_00935	annotation not available (1360 aa)
	Z518_02089	annotation not available (657 aa)
	Z518_01340	annotation not available (582 aa)
	Z518_01648	Checkpoint protein; Belongs to the HUS1 family. (356 aa)
	Z518_09206	annotation not available (1070 aa)
	Z518_03303	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2868 aa)
	Z518_07989	annotation not available (914 aa)
	Z518_08341	DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation. (463 aa)
	Z518_00450	annotation not available (1463 aa)
	Z518_01027	annotation not available (799 aa)
	Z518_06247	annotation not available (447 aa)
	Z518_02906	annotation not available (872 aa)
	Z518_03397	annotation not available (612 aa)
	Z518_00083	annotation not available (1150 aa)
	Z518_00690	RNA-dependent RNA polymerase. (1194 aa)
	Z518_00766	annotation not available (722 aa)

Your Current Organism:

Rhinocladiella mackenziei

NCBI taxonomy Id: 1442369
Other names: R. mackenziei CBS 650.93, Rhinocladiella mackenziei CBS 650.93

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Z518_00025	Z518_01340	A0A0D2G331	A0A0D2IW38	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	annotation not available	0.707
Z518_00025	Z518_02337	A0A0D2G331	A0A0D2HB70	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	annotation not available	0.707
Z518_00025	Z518_03233	A0A0D2G331	A0A0D2G259	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Serine/threonine-protein phosphatase.	0.911
Z518_00025	Z518_03906	A0A0D2G331	A0A0D2FV07	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	annotation not available	0.416
Z518_00025	Z518_04475	A0A0D2G331	A0A0D2ILD5	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	annotation not available	0.965
Z518_00025	Z518_05194	A0A0D2G331	A0A0D2FQ48	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	annotation not available	0.631
Z518_00025	Z518_07917	A0A0D2G331	A0A0D2GUL0	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	annotation not available	0.997
Z518_00025	Z518_08203	A0A0D2G331	A0A0D2I8U5	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Protein phosphatase PP2A regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	0.973
Z518_00025	Z518_09037	A0A0D2G331	A0A0D2FGZ7	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	annotation not available	0.435
Z518_00025	Z518_09038	A0A0D2G331	A0A0D2GSG9	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	annotation not available	0.435
Z518_00025	Z518_09524	A0A0D2G331	A0A0D2FIE4	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	0.877
Z518_00025	Z518_09761	A0A0D2G331	A0A0D2IBP2	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	annotation not available	0.661
Z518_00083	Z518_03233	A0A0D2JI45	A0A0D2G259	annotation not available	Serine/threonine-protein phosphatase.	0.571
Z518_00083	Z518_03397	A0A0D2JI45	A0A0D2JHA6	annotation not available	annotation not available	0.533
Z518_00083	Z518_07917	A0A0D2JI45	A0A0D2GUL0	annotation not available	annotation not available	0.927
Z518_00083	Z518_09524	A0A0D2JI45	A0A0D2FIE4	annotation not available	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	0.494
Z518_00450	Z518_09524	A0A0D2J100	A0A0D2FIE4	annotation not available	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	0.412
Z518_00456	Z518_06910	A0A0D2G400	A0A0D2GYU8	annotation not available	annotation not available	0.741
Z518_00456	Z518_09761	A0A0D2G400	A0A0D2IBP2	annotation not available	annotation not available	0.761
Z518_00935	Z518_01648	A0A0D2IUS6	A0A0D2IX41	annotation not available	Checkpoint protein; Belongs to the HUS1 family.	0.863