(75 nodes) Negative regulation of transcription, DNA-templated network (Rhinocladiella mackenziei)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Z518_05727	annotation not available (777 aa)
	Z518_09772	Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1135 aa)
	Z518_09193	annotation not available (475 aa)
	Z518_09273	annotation not available (754 aa)
	Z518_08131	annotation not available (431 aa)
	Z518_08719	annotation not available (160 aa)
	Z518_07605	annotation not available (367 aa)
	Z518_07630	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (1146 aa)
	Z518_05522	annotation not available (188 aa)
	Z518_06254	annotation not available (1166 aa)
	Z518_04151	annotation not available (785 aa)
	Z518_04788	Transcription elongation factor Spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression; Belongs to the SPT6 family. (1423 aa)
	Z518_02020	annotation not available (1035 aa)
	Z518_02245	annotation not available (1116 aa)
	Z518_02376	annotation not available (924 aa)
	Z518_01721	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (505 aa)
	Z518_11417	annotation not available (194 aa)
	Z518_10442	annotation not available (935 aa)
	Z518_09918	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (692 aa)
	Z518_09988	annotation not available (104 aa)
	Z518_09189	annotation not available (210 aa)
	Z518_08022	annotation not available (277 aa)
	Z518_05261	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (845 aa)
	Z518_04037	annotation not available (232 aa)
	Z518_04309	annotation not available (1175 aa)
	Z518_04334	annotation not available (715 aa)
	Z518_04359	annotation not available (443 aa)
	Z518_01846	annotation not available (608 aa)
	Z518_00221	annotation not available (164 aa)
	Z518_00513	annotation not available (847 aa)
	Z518_00533	annotation not available (363 aa)
	Z518_00894	annotation not available (373 aa)
	Z518_01571	annotation not available (621 aa)
	Z518_11346	annotation not available (1553 aa)
	Z518_08959	annotation not available (179 aa)
	Z518_09170	annotation not available (478 aa)
	Z518_09305	annotation not available (691 aa)
	Z518_08008	annotation not available (621 aa)
	Z518_08450	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (367 aa)
	Z518_10550	annotation not available (377 aa)
	Z518_08946	annotation not available (337 aa)
	Z518_09066	annotation not available (1143 aa)
	Z518_07662	annotation not available (264 aa)
	Z518_09452	Ubiquitin carboxyl-terminal hydrolase. (721 aa)
	Z518_08080	annotation not available (678 aa)
	Z518_05886	annotation not available (422 aa)
	Z518_05916	annotation not available (830 aa)
	Z518_08789	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (255 aa)
	Z518_06341	annotation not available (793 aa)
	Z518_04033	Non-specific serine/threonine protein kinase. (879 aa)
	Z518_02092	annotation not available (92 aa)
	Z518_05853	annotation not available (542 aa)
	Z518_02563	annotation not available (337 aa)
	Z518_11352	annotation not available (482 aa)
	Z518_11168	annotation not available (891 aa)
	Z518_00032	annotation not available (1509 aa)
	Z518_01000	Non-specific serine/threonine protein kinase. (886 aa)
	Z518_02545	annotation not available (659 aa)
	Z518_02922	annotation not available (116 aa)
	Z518_08034	annotation not available (864 aa)
	Z518_01017	annotation not available (954 aa)
	Z518_01624	annotation not available (694 aa)
	Z518_07518	annotation not available (622 aa)
	Z518_07688	annotation not available (569 aa)
	Z518_07709	annotation not available (356 aa)
	Z518_05505	annotation not available (605 aa)
	Z518_05530	annotation not available (521 aa)
	Z518_05535	annotation not available (485 aa)
	Z518_06022	annotation not available (400 aa)
	Z518_04039	annotation not available (544 aa)
	Z518_04195	annotation not available (1990 aa)
	Z518_02690	annotation not available (362 aa)
	Z518_03186	annotation not available (636 aa)
	Z518_00138	annotation not available (356 aa)
	Z518_00971	annotation not available (391 aa)

Your Current Organism:

Rhinocladiella mackenziei

NCBI taxonomy Id: 1442369
Other names: R. mackenziei CBS 650.93, Rhinocladiella mackenziei CBS 650.93

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Z518_00032	Z518_00221	A0A0D2ISJ9	A0A0D2HES0	annotation not available	annotation not available	0.451
Z518_00032	Z518_00971	A0A0D2ISJ9	A0A0D2JK66	annotation not available	annotation not available	0.736
Z518_00032	Z518_01624	A0A0D2ISJ9	A0A0D2J4E4	annotation not available	annotation not available	0.572
Z518_00032	Z518_02690	A0A0D2ISJ9	A0A0D2JFK5	annotation not available	annotation not available	0.494
Z518_00032	Z518_04037	A0A0D2ISJ9	A0A0D2H6P8	annotation not available	annotation not available	0.451
Z518_00032	Z518_05261	A0A0D2ISJ9	A0A0D2H1S6	annotation not available	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.494
Z518_00032	Z518_05886	A0A0D2ISJ9	A0A0D2IGZ1	annotation not available	annotation not available	0.464
Z518_00032	Z518_07630	A0A0D2ISJ9	A0A0D2FPH6	annotation not available	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.672
Z518_00032	Z518_07688	A0A0D2ISJ9	A0A0D2J557	annotation not available	annotation not available	0.508
Z518_00032	Z518_08022	A0A0D2ISJ9	A0A0D2GUZ2	annotation not available	annotation not available	0.451
Z518_00032	Z518_08080	A0A0D2ISJ9	A0A0D2IFU6	annotation not available	annotation not available	0.483
Z518_00032	Z518_08946	A0A0D2ISJ9	A0A0D2IDB5	annotation not available	annotation not available	0.572
Z518_00032	Z518_11168	A0A0D2ISJ9	A0A0D2IRS0	annotation not available	annotation not available	0.451
Z518_00032	Z518_11417	A0A0D2ISJ9	A0A0D2GLT3	annotation not available	annotation not available	0.451
Z518_00138	Z518_07662	A0A0D2JI74	A0A0D2IE62	annotation not available	annotation not available	0.598
Z518_00138	Z518_11352	A0A0D2JI74	A0A0D2IRH9	annotation not available	annotation not available	0.598
Z518_00221	Z518_00032	A0A0D2HES0	A0A0D2ISJ9	annotation not available	annotation not available	0.451
Z518_00221	Z518_02690	A0A0D2HES0	A0A0D2JFK5	annotation not available	annotation not available	0.440
Z518_00221	Z518_05261	A0A0D2HES0	A0A0D2H1S6	annotation not available	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.440
Z518_00513	Z518_00971	A0A0D2HFG9	A0A0D2JK66	annotation not available	annotation not available	0.411