(28 nodes) Valine, leucine and isoleucine biosynthesis network (Fonsecaea multimorphosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Z520_09801	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (683 aa)
	Z520_06453	Pyruvate carboxyltransferase domain-containing protein. (619 aa)
	Z520_05731	Uncharacterized protein. (630 aa)
	Z520_04486	Uncharacterized protein. (760 aa)
	Z520_01673	Uncharacterized protein. (655 aa)
	Z520_11429	Uncharacterized protein. (762 aa)
	Z520_10001	ACT domain-containing protein. (351 aa)
	Z520_07989	Homocitrate synthase, mitochondrial; Belongs to the alpha-IPM synthase/homocitrate synthase family. (500 aa)
	Z520_05827	Threonine dehydratase. (563 aa)
	Z520_04497	Acetolactate synthase. (699 aa)
	Z520_03059	Pyruvate carboxyltransferase domain-containing protein. (679 aa)
	Z520_12098	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (457 aa)
	Z520_10083	Uncharacterized protein; Belongs to the TPP enzyme family. (617 aa)
	Z520_08065	PALP domain-containing protein. (360 aa)
	Z520_10952	Uncharacterized protein. (380 aa)
	Z520_08911	Uncharacterized protein. (337 aa)
	Z520_07118	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (459 aa)
	Z520_04485	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (388 aa)
	Z520_10589	Uncharacterized protein. (658 aa)
	Z520_10392	Uncharacterized protein. (615 aa)
	Z520_01537	Ketol-acid reductoisomerase, mitochondrial; Belongs to the ketol-acid reductoisomerase family. (407 aa)
	Z520_06950	Uncharacterized protein. (638 aa)
	Z520_06441	Uncharacterized protein. (649 aa)
	Z520_03359	3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (775 aa)
	Z520_01014	Uncharacterized protein. (602 aa)
	Z520_01289	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (372 aa)
	Z520_01536	PALP domain-containing protein. (415 aa)
	Z520_00235	Uncharacterized protein; Belongs to the TPP enzyme family. (630 aa)

Your Current Organism:

Fonsecaea multimorphosa

NCBI taxonomy Id: 1442371
Other names: F. multimorphosa CBS 102226, Fonsecaea multimorphosa CBS 102226

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Z520_00235	Z520_01014	A0A0D2L3A8	A0A0D2L0J9	Uncharacterized protein; Belongs to the TPP enzyme family.	Uncharacterized protein.	0.481
Z520_00235	Z520_01289	A0A0D2L3A8	A0A0D2L1A8	Uncharacterized protein; Belongs to the TPP enzyme family.	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	0.484
Z520_00235	Z520_01536	A0A0D2L3A8	A0A0D2L1X5	Uncharacterized protein; Belongs to the TPP enzyme family.	PALP domain-containing protein.	0.594
Z520_00235	Z520_01537	A0A0D2L3A8	A0A0D2KHX5	Uncharacterized protein; Belongs to the TPP enzyme family.	Ketol-acid reductoisomerase, mitochondrial; Belongs to the ketol-acid reductoisomerase family.	0.425
Z520_00235	Z520_01673	A0A0D2L3A8	A0A0D2HMY0	Uncharacterized protein; Belongs to the TPP enzyme family.	Uncharacterized protein.	0.481
Z520_00235	Z520_03059	A0A0D2L3A8	A0A0D2IWZ2	Uncharacterized protein; Belongs to the TPP enzyme family.	Pyruvate carboxyltransferase domain-containing protein.	0.525
Z520_00235	Z520_03359	A0A0D2L3A8	A0A0D2KVA9	Uncharacterized protein; Belongs to the TPP enzyme family.	3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.	0.626
Z520_00235	Z520_04485	A0A0D2L3A8	A0A0D2K9L1	Uncharacterized protein; Belongs to the TPP enzyme family.	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	0.484
Z520_00235	Z520_04486	A0A0D2L3A8	A0A0D2HD89	Uncharacterized protein; Belongs to the TPP enzyme family.	Uncharacterized protein.	0.626
Z520_00235	Z520_05731	A0A0D2L3A8	A0A0D2H9B8	Uncharacterized protein; Belongs to the TPP enzyme family.	Uncharacterized protein.	0.481
Z520_00235	Z520_05827	A0A0D2L3A8	A0A0D2INC7	Uncharacterized protein; Belongs to the TPP enzyme family.	Threonine dehydratase.	0.637
Z520_00235	Z520_06441	A0A0D2L3A8	A0A0D2KLT5	Uncharacterized protein; Belongs to the TPP enzyme family.	Uncharacterized protein.	0.481
Z520_00235	Z520_06453	A0A0D2L3A8	A0A0D2H736	Uncharacterized protein; Belongs to the TPP enzyme family.	Pyruvate carboxyltransferase domain-containing protein.	0.469
Z520_00235	Z520_06950	A0A0D2L3A8	A0A0D2KLH3	Uncharacterized protein; Belongs to the TPP enzyme family.	Uncharacterized protein.	0.469
Z520_00235	Z520_07118	A0A0D2L3A8	A0A0D2K1X4	Uncharacterized protein; Belongs to the TPP enzyme family.	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	0.484
Z520_00235	Z520_07989	A0A0D2L3A8	A0A0D2IGM3	Uncharacterized protein; Belongs to the TPP enzyme family.	Homocitrate synthase, mitochondrial; Belongs to the alpha-IPM synthase/homocitrate synthase family.	0.469
Z520_00235	Z520_08065	A0A0D2L3A8	A0A0D2JS55	Uncharacterized protein; Belongs to the TPP enzyme family.	PALP domain-containing protein.	0.597
Z520_00235	Z520_08911	A0A0D2L3A8	A0A0D2JY13	Uncharacterized protein; Belongs to the TPP enzyme family.	Uncharacterized protein.	0.746
Z520_00235	Z520_09801	A0A0D2L3A8	A0A0D2GY18	Uncharacterized protein; Belongs to the TPP enzyme family.	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.746
Z520_00235	Z520_10001	A0A0D2L3A8	A0A0D2IAV9	Uncharacterized protein; Belongs to the TPP enzyme family.	ACT domain-containing protein.	0.957