(94 nodes) mRNA Splicing network (Fonsecaea multimorphosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Z520_11659	Uncharacterized protein. (531 aa)
	Z520_11333	U1-type domain-containing protein. (299 aa)
	Z520_10410	Pre-mRNA-splicing ATP-dependent RNA helicase prp28. (836 aa)
	Z520_09736	Uncharacterized protein. (2243 aa)
	Z520_08822	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. (184 aa)
	Z520_08715	Pre-mRNA-processing ATP-dependent RNA helicase prp5. (1092 aa)
	Z520_08427	PHD finger-like domain-containing protein 5B. (110 aa)
	Z520_07736	Nuclear cap-binding protein subunit 2. (173 aa)
	Z520_07364	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (162 aa)
	Z520_07500	Uncharacterized protein. (324 aa)
	Z520_07625	Uncharacterized protein. (157 aa)
	Z520_06707	RRM domain-containing protein. (154 aa)
	Z520_06094	Uncharacterized protein. (848 aa)
	Z520_04896	Pre-mRNA-processing protein 45. (585 aa)
	Z520_04253	PSP domain-containing protein. (597 aa)
	Z520_03582	Pre-mRNA-splicing factor cwc22. (662 aa)
	Z520_02429	Pre-mRNA-processing-splicing factor 8. (2670 aa)
	Z520_02459	Pre-mRNA-splicing factor rse1. (1211 aa)
	Z520_01136	Pre-mRNA-splicing factor slt11. (383 aa)
	Z520_00292	Uncharacterized protein. (990 aa)
	Z520_11992	FHA domain-containing protein. (260 aa)
	Z520_11786	PPIase cyclophilin-type domain-containing protein. (567 aa)
	Z520_11377	Uncharacterized protein. (252 aa)
	Z520_10602	PWI domain-containing protein. (279 aa)
	Z520_10258	Pre-mRNA-splicing factor; Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome. (1418 aa)
	Z520_10016	Uncharacterized protein. (668 aa)
	Z520_09511	Uncharacterized protein. (385 aa)
	Z520_09067	Nop domain-containing protein. (602 aa)
	Z520_08311	Uncharacterized protein. (663 aa)
	Z520_07707	Uncharacterized protein. (985 aa)
	Z520_07777	Tudor domain-containing protein. (293 aa)
	Z520_07847	Uncharacterized protein. (672 aa)
	Z520_07481	Uncharacterized protein. (446 aa)
	Z520_07576	Uncharacterized protein. (321 aa)
	Z520_06186	Uncharacterized protein. (160 aa)
	Z520_06286	RRM domain-containing protein. (325 aa)
	Z520_05722	RRM domain-containing protein. (116 aa)
	Z520_02639	Uncharacterized protein. (248 aa)
	Z520_01709	SF3b1 domain-containing protein. (1230 aa)
	Z520_00659	Pre-mRNA-splicing factor syf1. (853 aa)
	Z520_00874	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43. (765 aa)
	Z520_11194	Uncharacterized protein. (978 aa)
	Z520_11066	DUF1716 domain-containing protein. (611 aa)
	Z520_09813	Matrin-type domain-containing protein. (238 aa)
	Z520_09068	Pre-mRNA-splicing factor clf1. (680 aa)
	Z520_12045	Uncharacterized protein. (302 aa)
	Z520_10808	Small nuclear ribonucleoprotein Sm D1; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site; Belongs to the snRNP core protein family. (177 aa)
	Z520_09989	Cwf21 domain-containing protein. (186 aa)
	Z520_06096	Uncharacterized protein. (335 aa)
	Z520_08871	Cir_N domain-containing protein. (396 aa)
	Z520_08644	Uncharacterized protein. (388 aa)
	Z520_05813	RRM domain-containing protein. (196 aa)
	Z520_05948	CID domain-containing protein. (620 aa)
	Z520_08179	Uncharacterized protein. (214 aa)
	Z520_05448	WD_REPEATS_REGION domain-containing protein. (511 aa)
	Z520_07058	Uncharacterized protein. (331 aa)
	Z520_07283	Uncharacterized protein. (563 aa)
	Z520_06517	G-patch_2 domain-containing protein. (478 aa)
	Z520_03373	Small nuclear ribonucleoprotein G. (80 aa)
	Z520_06174	Sm domain-containing protein. (93 aa)
	Z520_06189	Uncharacterized protein. (1456 aa)
	Z520_05670	Uncharacterized protein. (205 aa)
	Z520_02845	Pre-mRNA-splicing factor cef1. (774 aa)
	Z520_03055	WD_REPEATS_REGION domain-containing protein. (360 aa)
	Z520_02041	Pre-mRNA-splicing factor isy1. (252 aa)
	Z520_11657	Uncharacterized protein. (310 aa)
	Z520_04395	C2H2-type domain-containing protein. (218 aa)
	Z520_01103	Uncharacterized protein. (207 aa)
	Z520_10956	Sm domain-containing protein. (256 aa)
	Z520_10903	Isochorismatase domain-containing protein. (316 aa)
	Z520_04045	F-box domain-containing protein. (608 aa)
	Z520_00114	CID domain-containing protein. (964 aa)
	Z520_00509	Spliceosomal protein DIB1; Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis; Belongs to the DIM1 family. (143 aa)
	Z520_00544	Small nuclear ribonucleoprotein Sm D2. (103 aa)
	LSM8	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (98 aa)
	Z520_09899	Uncharacterized protein. (518 aa)
	Z520_09629	Matrin-type domain-containing protein. (540 aa)
	Z520_00700	RRM domain-containing protein. (414 aa)
	Z520_00720	Small nuclear ribonucleoprotein Sm D3. (116 aa)
	Z520_00745	MFAP1 domain-containing protein. (520 aa)
	Z520_08815	Splicing factor subunit; Belongs to the SF3B5 family. (85 aa)
	Z520_08486	Uncharacterized protein. (1300 aa)
	Z520_08378	WD_REPEATS_REGION domain-containing protein. (590 aa)
	Z520_06880	Slu7 domain-containing protein. (545 aa)
	Z520_05044	Uncharacterized protein. (307 aa)
	Z520_04328	Uncharacterized protein. (595 aa)
	Z520_04626	Uncharacterized protein. (218 aa)
	Z520_02686	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (94 aa)
	Z520_00265	Tr-type G domain-containing protein. (982 aa)
	Z520_00315	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (196 aa)
	Z520_00525	Pre-mRNA-splicing factor prp46. (436 aa)
	Z520_00661	Uncharacterized protein. (268 aa)
	Z520_00696	Uncharacterized protein. (478 aa)
	Z520_00821	Uncharacterized protein. (1228 aa)

Your Current Organism:

Fonsecaea multimorphosa

NCBI taxonomy Id: 1442371
Other names: F. multimorphosa CBS 102226, Fonsecaea multimorphosa CBS 102226

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LSM8	Z520_00265	A0A0D2KCK7	A0A0D2L3E3	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Tr-type G domain-containing protein.	0.989
LSM8	Z520_00315	A0A0D2KCK7	A0A0D2L3K3	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.803
LSM8	Z520_00509	A0A0D2KCK7	A0A0D2KCD6	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Spliceosomal protein DIB1; Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis; Belongs to the DIM1 family.	0.973
LSM8	Z520_00525	A0A0D2KCK7	A0A0D2L434	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Pre-mRNA-splicing factor prp46.	0.655
LSM8	Z520_00544	A0A0D2KCK7	A0A0D2KCI5	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Small nuclear ribonucleoprotein Sm D2.	0.989
LSM8	Z520_00661	A0A0D2KCK7	A0A0D2L4J2	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Uncharacterized protein.	0.892
LSM8	Z520_00696	A0A0D2KCK7	A0A0D2L4M0	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Uncharacterized protein.	0.500
LSM8	Z520_00700	A0A0D2KCK7	A0A0D2KD01	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	RRM domain-containing protein.	0.583
LSM8	Z520_00720	A0A0D2KCK7	A0A0D2KD19	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Small nuclear ribonucleoprotein Sm D3.	0.984
LSM8	Z520_00745	A0A0D2KCK7	A0A0D2KD48	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	MFAP1 domain-containing protein.	0.715
LSM8	Z520_01136	A0A0D2KCK7	A0A0D2HL67	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Pre-mRNA-splicing factor slt11.	0.663
LSM8	Z520_01709	A0A0D2KCK7	A0A0D2J1G8	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	SF3b1 domain-containing protein.	0.920
LSM8	Z520_02429	A0A0D2KCK7	A0A0D2HK66	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Pre-mRNA-processing-splicing factor 8.	0.987
LSM8	Z520_02459	A0A0D2KCK7	A0A0D2HKA9	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Pre-mRNA-splicing factor rse1.	0.914
LSM8	Z520_02639	A0A0D2KCK7	A0A0D2IVK1	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Uncharacterized protein.	0.950
LSM8	Z520_02686	A0A0D2KCK7	A0A0D2KWF9	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.	0.989
LSM8	Z520_02845	A0A0D2KCK7	A0A0D2K642	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Pre-mRNA-splicing factor cef1.	0.655
LSM8	Z520_03055	A0A0D2KCK7	A0A0D2K6M5	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	WD_REPEATS_REGION domain-containing protein.	0.788
LSM8	Z520_03373	A0A0D2KCK7	A0A0D2K4G1	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Small nuclear ribonucleoprotein G.	0.991
LSM8	Z520_04045	A0A0D2KCK7	A0A0D2KB42	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	F-box domain-containing protein.	0.935