(18 nodes) Mixed, incl. HDR through Single Strand Annealing (SSA), and Checkpoint clamp complex network (Fonsecaea multimorphosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Z520_08705	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (349 aa)
	Z520_10860	Uncharacterized protein. (909 aa)
	Z520_10071	Uncharacterized protein. (158 aa)
	Z520_08433	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (606 aa)
	Z520_08469	Uncharacterized protein. (543 aa)
	Z520_00398	XPGI domain-containing protein. (827 aa)
	Z520_00724	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2910 aa)
	Z520_09987	Checkpoint protein; Belongs to the HUS1 family. (349 aa)
	Z520_09452	Uncharacterized protein. (369 aa)
	Z520_07386	Uncharacterized protein. (1103 aa)
	Z520_08654	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2301 aa)
	Z520_05770	Uncharacterized protein. (1623 aa)
	Z520_03203	DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation. (475 aa)
	Z520_09754	Uncharacterized protein. (1703 aa)
	Z520_02792	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (781 aa)
	Z520_00942	Uncharacterized protein. (280 aa)
	Z520_02363	AAA_23 domain-containing protein. (1305 aa)
	Z520_04764	SAE2 domain-containing protein. (400 aa)

Your Current Organism:

Fonsecaea multimorphosa

NCBI taxonomy Id: 1442371
Other names: F. multimorphosa CBS 102226, Fonsecaea multimorphosa CBS 102226

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Z520_00398	Z520_00724	A0A0D2J2P1	A0A0D2J3S2	XPGI domain-containing protein.	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.	0.763
Z520_00398	Z520_00942	A0A0D2J2P1	A0A0D2KDR1	XPGI domain-containing protein.	Uncharacterized protein.	0.726
Z520_00398	Z520_02363	A0A0D2J2P1	A0A0D2KFH3	XPGI domain-containing protein.	AAA_23 domain-containing protein.	0.851
Z520_00398	Z520_02792	A0A0D2J2P1	A0A0D2KDE1	XPGI domain-containing protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.909
Z520_00398	Z520_03203	A0A0D2J2P1	A0A0D2KBS0	XPGI domain-containing protein.	DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation.	0.743
Z520_00398	Z520_05770	A0A0D2J2P1	A0A0D2K5P2	XPGI domain-containing protein.	Uncharacterized protein.	0.800
Z520_00398	Z520_07386	A0A0D2J2P1	A0A0D2JT65	XPGI domain-containing protein.	Uncharacterized protein.	0.786
Z520_00398	Z520_08433	A0A0D2J2P1	A0A0D2IF42	XPGI domain-containing protein.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.801
Z520_00398	Z520_08469	A0A0D2J2P1	A0A0D2IF78	XPGI domain-containing protein.	Uncharacterized protein.	0.789
Z520_00398	Z520_08654	A0A0D2J2P1	A0A0D2JYA9	XPGI domain-containing protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.823
Z520_00398	Z520_08705	A0A0D2J2P1	A0A0D2H170	XPGI domain-containing protein.	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	0.751
Z520_00398	Z520_09452	A0A0D2J2P1	A0A0D2JN33	XPGI domain-containing protein.	Uncharacterized protein.	0.679
Z520_00398	Z520_09754	A0A0D2J2P1	A0A0D2KCD4	XPGI domain-containing protein.	Uncharacterized protein.	0.880
Z520_00398	Z520_09987	A0A0D2J2P1	A0A0D2JLS0	XPGI domain-containing protein.	Checkpoint protein; Belongs to the HUS1 family.	0.707
Z520_00398	Z520_10071	A0A0D2J2P1	A0A0D2IB32	XPGI domain-containing protein.	Uncharacterized protein.	0.800
Z520_00398	Z520_10860	A0A0D2J2P1	A0A0D2I8D9	XPGI domain-containing protein.	Uncharacterized protein.	0.672
Z520_00724	Z520_00398	A0A0D2J3S2	A0A0D2J2P1	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.	XPGI domain-containing protein.	0.763
Z520_00724	Z520_00942	A0A0D2J3S2	A0A0D2KDR1	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.	Uncharacterized protein.	0.814
Z520_00724	Z520_02363	A0A0D2J3S2	A0A0D2KFH3	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.	AAA_23 domain-containing protein.	0.987
Z520_00724	Z520_02792	A0A0D2J3S2	A0A0D2KDE1	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.990