(47 nodes) Regulation of DNA metabolic process network (Fonsecaea multimorphosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Z520_08655	Chromosome segregation in meiosis protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (505 aa)
	Z520_07891	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (263 aa)
	Z520_06802	DNA helicase; Belongs to the MCM family. (894 aa)
	Z520_06275	Uncharacterized protein. (149 aa)
	Z520_05631	Uncharacterized protein. (683 aa)
	Z520_01884	Uncharacterized protein. (1129 aa)
	Z520_09946	WD_REPEATS_REGION domain-containing protein. (571 aa)
	Z520_08771	Uncharacterized protein. (760 aa)
	Z520_07336	Uncharacterized protein. (559 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (814 aa)
	Z520_05832	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1241 aa)
	Z520_03942	Deacetylase sirtuin-type domain-containing protein. (649 aa)
	Z520_04187	DNA helicase; Belongs to the MCM family. (842 aa)
	Z520_00448	Uncharacterized protein. (516 aa)
	Z520_00518	Telo_bind domain-containing protein. (663 aa)
	Z520_00634	Uncharacterized protein. (707 aa)
	Z520_00639	Serine/threonine-protein phosphatase. (452 aa)
	Z520_12380	DNA helicase; Belongs to the MCM family. (725 aa)
	Z520_10123	Uncharacterized protein. (504 aa)
	Z520_11977	Uncharacterized protein. (761 aa)
	Z520_08035	Uncharacterized protein. (148 aa)
	Z520_07798	DNA helicase; Belongs to the MCM family. (1006 aa)
	Z520_07893	Vezatin domain-containing protein. (591 aa)
	Z520_06545	Uncharacterized protein. (702 aa)
	Z520_06232	DNA helicase; Belongs to the MCM family. (963 aa)
	Z520_09095	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (624 aa)
	Z520_08654	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2301 aa)
	Z520_08532	Uncharacterized protein. (870 aa)
	Z520_08249	Cell division control protein; Belongs to the CDC6/cdc18 family. (607 aa)
	Z520_05553	H15 domain-containing protein. (228 aa)
	Z520_05043	Uncharacterized protein. (719 aa)
	Z520_03923	SMK-1 domain-containing protein. (919 aa)
	Z520_04820	Uncharacterized protein. (380 aa)
	Z520_11657	Uncharacterized protein. (310 aa)
	Z520_10644	Uncharacterized protein. (794 aa)
	Z520_10305	Uncharacterized protein. (792 aa)
	Z520_02363	AAA_23 domain-containing protein. (1305 aa)
	Z520_08743	Deacetylase sirtuin-type domain-containing protein. (608 aa)
	Z520_01175	Plus3 domain-containing protein. (616 aa)
	Z520_01320	MRC1 domain-containing protein. (1354 aa)
	Z520_01345	Uncharacterized protein. (1120 aa)
	Z520_00136	Uncharacterized protein. (334 aa)
	Z520_06355	HECT domain-containing protein. (1874 aa)
	Z520_06691	Rif1_N domain-containing protein. (1472 aa)
	Z520_04231	DNA repair helicase rad15. (815 aa)
	Z520_04124	DBF4-type domain-containing protein. (644 aa)
	Z520_01149	Uncharacterized protein. (1183 aa)

Your Current Organism:

Fonsecaea multimorphosa

NCBI taxonomy Id: 1442371
Other names: F. multimorphosa CBS 102226, Fonsecaea multimorphosa CBS 102226

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MCM7	Z520_00634	A0A0D2ILH4	A0A0D2J3J3	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Uncharacterized protein.	0.416
MCM7	Z520_01149	A0A0D2ILH4	A0A0D2L0X1	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Uncharacterized protein.	0.980
MCM7	Z520_01320	A0A0D2ILH4	A0A0D2KHC0	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	MRC1 domain-containing protein.	0.601
MCM7	Z520_04124	A0A0D2ILH4	A0A0D2KUQ3	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DBF4-type domain-containing protein.	0.984
MCM7	Z520_04187	A0A0D2ILH4	A0A0D2IU37	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	Z520_04820	A0A0D2ILH4	A0A0D2K7U9	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Uncharacterized protein.	0.553
MCM7	Z520_06232	A0A0D2ILH4	A0A0D2JX56	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	Z520_06545	A0A0D2ILH4	A0A0D2JW76	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Uncharacterized protein.	0.461
MCM7	Z520_06802	A0A0D2ILH4	A0A0D2H684	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	Z520_07798	A0A0D2ILH4	A0A0D2JSU2	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	Z520_07891	A0A0D2ILH4	A0A0D2H452	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.933
MCM7	Z520_07893	A0A0D2ILH4	A0A0D2JT28	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Vezatin domain-containing protein.	0.933
MCM7	Z520_08249	A0A0D2ILH4	A0A0D2JZI1	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Cell division control protein; Belongs to the CDC6/cdc18 family.	0.999
MCM7	Z520_08654	A0A0D2ILH4	A0A0D2JYA9	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.729
MCM7	Z520_08655	A0A0D2ILH4	A0A0D2H129	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Chromosome segregation in meiosis protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.985
MCM7	Z520_12380	A0A0D2ILH4	A0A0D2JFH9	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
Z520_00136	Z520_11657	A0A0D2KJ14	A0A0D2K8F6	Uncharacterized protein.	Uncharacterized protein.	0.661
Z520_00448	Z520_06355	A0A0D2J2U2	A0A0D2KLL8	Uncharacterized protein.	HECT domain-containing protein.	0.955
Z520_00518	Z520_02363	A0A0D2J329	A0A0D2KFH3	Telo_bind domain-containing protein.	AAA_23 domain-containing protein.	0.636
Z520_00518	Z520_04231	A0A0D2J329	A0A0D2KSB3	Telo_bind domain-containing protein.	DNA repair helicase rad15.	0.654