(44 nodes) Rossmann-like alpha/beta/alpha sandwich fold network (Fonsecaea multimorphosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Z520_12229	Photolyase/cryptochrome alpha/beta domain-containing protein. (588 aa)
	MET3	Sulfate adenylyltransferase; Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids. In the N-terminal section; belongs to the sulfate adenylyltransferase family. (573 aa)
	Z520_11328	CTP_transf_like domain-containing protein. (431 aa)
	Z520_10661	Photolyase/cryptochrome alpha/beta domain-containing protein. (617 aa)
	Z520_09192	Uncharacterized protein. (335 aa)
	Z520_07876	Uncharacterized protein. (1125 aa)
	Z520_07515	ETF domain-containing protein. (255 aa)
	NCS6	Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (410 aa)
	Z520_06977	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (642 aa)
	Z520_06305	CTP_transf_like domain-containing protein. (497 aa)
	Z520_05831	Tyrosine--tRNA ligase. (607 aa)
	Z520_02648	ATP_bind_3 domain-containing protein. (632 aa)
	Z520_01894	PAPS_reduct domain-containing protein. (362 aa)
	Z520_02009	GMP synthase [glutamine-hydrolyzing]. (548 aa)
	Z520_02119	DALR_1 domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (631 aa)
	Z520_00152	Uncharacterized protein. (409 aa)
	Z520_12087	Phosphoadenosine phosphosulfate reductase. (307 aa)
	Z520_10537	tRNA-synt_1e domain-containing protein. (814 aa)
	Z520_09178	Glutamine amidotransferase type-2 domain-containing protein. (591 aa)
	Z520_06484	Diphthami_syn_2 domain-containing protein. (871 aa)
	Z520_05452	DUF218 domain-containing protein. (276 aa)
	Z520_03432	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (547 aa)
	Z520_03154	Tyrosine--tRNA ligase. (414 aa)
	Z520_02550	tRNA-synt_1g domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (660 aa)
	Z520_12299	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (511 aa)
	Z520_09788	Glutamine amidotransferase type-2 domain-containing protein. (640 aa)
	Z520_11927	ETF domain-containing protein. (349 aa)
	Z520_10942	tRNA-synt_1g domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (589 aa)
	Z520_10479	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (1009 aa)
	Z520_06650	Uncharacterized protein. (447 aa)
	Z520_06222	tRNA-synt_1c domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (620 aa)
	Z520_07710	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (637 aa)
	Z520_04534	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (1088 aa)
	Z520_06356	Nicotinamide-nucleotide adenylyltransferase; Belongs to the eukaryotic NMN adenylyltransferase family. (269 aa)
	Z520_03221	Photolyase/cryptochrome alpha/beta domain-containing protein. (541 aa)
	Z520_05870	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. (720 aa)
	Z520_02096	Usp domain-containing protein. (675 aa)
	Z520_03340	Usp domain-containing protein. (475 aa)
	Z520_02937	Photolyase/cryptochrome alpha/beta domain-containing protein. (718 aa)
	Z520_03027	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (872 aa)
	NCS2	Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (359 aa)
	Z520_01766	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (430 aa)
	Z520_00220	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (1030 aa)
	Z520_00585	Uncharacterized protein. (442 aa)

Your Current Organism:

Fonsecaea multimorphosa

NCBI taxonomy Id: 1442371
Other names: F. multimorphosa CBS 102226, Fonsecaea multimorphosa CBS 102226

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MET3	Z520_01894	A0A0D2GRR7	A0A0D2HIL2	Sulfate adenylyltransferase; Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids. In the N-terminal section; belongs to the sulfate adenylyltransferase family.	PAPS_reduct domain-containing protein.	0.939
MET3	Z520_09178	A0A0D2GRR7	A0A0D2IDP3	Sulfate adenylyltransferase; Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids. In the N-terminal section; belongs to the sulfate adenylyltransferase family.	Glutamine amidotransferase type-2 domain-containing protein.	0.507
MET3	Z520_12087	A0A0D2GRR7	A0A0D2I4K5	Sulfate adenylyltransferase; Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids. In the N-terminal section; belongs to the sulfate adenylyltransferase family.	Phosphoadenosine phosphosulfate reductase.	0.967
NCS2	NCS6	A0A0D2KJY6	A0A0D2H5R3	Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.	Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.	0.995
NCS2	Z520_02648	A0A0D2KJY6	A0A0D2HGQ4	Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.	ATP_bind_3 domain-containing protein.	0.976
NCS6	NCS2	A0A0D2H5R3	A0A0D2KJY6	Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.	Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.	0.995
NCS6	Z520_02009	A0A0D2H5R3	A0A0D2HJ02	Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.	GMP synthase [glutamine-hydrolyzing].	0.818
NCS6	Z520_10537	A0A0D2H5R3	A0A0D2I8W3	Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.	tRNA-synt_1e domain-containing protein.	0.482
Z520_00152	Z520_09178	A0A0D2HNS5	A0A0D2IDP3	Uncharacterized protein.	Glutamine amidotransferase type-2 domain-containing protein.	0.896
Z520_00152	Z520_09788	A0A0D2HNS5	A0A0D2JM82	Uncharacterized protein.	Glutamine amidotransferase type-2 domain-containing protein.	0.752
Z520_00220	Z520_01766	A0A0D2L394	A0A0D2L2N5	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.596
Z520_00220	Z520_02009	A0A0D2L394	A0A0D2HJ02	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	GMP synthase [glutamine-hydrolyzing].	0.780
Z520_00220	Z520_02119	A0A0D2L394	A0A0D2HJC2	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	DALR_1 domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.675
Z520_00220	Z520_02550	A0A0D2L394	A0A0D2IZF5	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	tRNA-synt_1g domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.725
Z520_00220	Z520_03027	A0A0D2L394	A0A0D2KDW6	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.882
Z520_00220	Z520_03154	A0A0D2L394	A0A0D2IX54	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	Tyrosine--tRNA ligase.	0.700
Z520_00220	Z520_03432	A0A0D2L394	A0A0D2IUN5	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.644
Z520_00220	Z520_04534	A0A0D2L394	A0A0D2K228	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.869
Z520_00220	Z520_05831	A0A0D2L394	A0A0D2H9I9	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	Tyrosine--tRNA ligase.	0.694
Z520_00220	Z520_06222	A0A0D2L394	A0A0D2JX43	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	tRNA-synt_1c domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.604