(79 nodes) Butanoate metabolism network (Fonsecaea multimorphosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Z520_11608	Uncharacterized protein. (566 aa)
	Z520_08519	AMP-binding domain-containing protein. (676 aa)
	Z520_07085	Uncharacterized protein. (219 aa)
	Z520_07235	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (284 aa)
	Z520_06788	Uncharacterized protein. (268 aa)
	Z520_06115	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (498 aa)
	Z520_06231	Aldedh domain-containing protein. (464 aa)
	Z520_04321	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (295 aa)
	Z520_04497	Acetolactate synthase. (699 aa)
	Z520_04594	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (443 aa)
	Z520_04670	Aldedh domain-containing protein. (510 aa)
	Z520_03573	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (286 aa)
	Z520_03114	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (562 aa)
	Z520_01865	Uncharacterized protein. (314 aa)
	Z520_02110	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (492 aa)
	Z520_02115	PKS_ER domain-containing protein. (362 aa)
	Z520_00473	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (469 aa)
	Z520_10001	ACT domain-containing protein. (351 aa)
	Z520_12053	Glutamate decarboxylase; Belongs to the group II decarboxylase family. (526 aa)
	Z520_11144	Uncharacterized protein. (245 aa)
	Z520_09427	Uncharacterized protein. (288 aa)
	Z520_09492	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (493 aa)
	Z520_12060	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (483 aa)
	Z520_11497	Uncharacterized protein. (380 aa)
	Z520_11302	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (582 aa)
	Z520_07086	Uncharacterized protein; Belongs to the TPP enzyme family. (564 aa)
	Z520_10306	Succinate-semialdehyde dehydrogenase. (497 aa)
	Z520_07755	AMP-binding domain-containing protein. (703 aa)
	Z520_04282	Aldedh domain-containing protein. (517 aa)
	Z520_04418	Uncharacterized protein. (924 aa)
	Z520_07198	Pyruvate carboxyltransferase domain-containing protein. (620 aa)
	Z520_06371	PKS_ER domain-containing protein. (800 aa)
	Z520_03005	AMP-binding domain-containing protein. (702 aa)
	Z520_04965	AMP-binding domain-containing protein. (666 aa)
	Z520_12262	Uncharacterized protein. (522 aa)
	Z520_00925	Uncharacterized protein. (694 aa)
	Z520_00658	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (476 aa)
	Z520_00087	Uncharacterized protein. (246 aa)
	Z520_00077	AMP-binding domain-containing protein. (757 aa)
	Z520_01457	Fungal_trans domain-containing protein. (673 aa)
	Z520_02590	Aldedh domain-containing protein. (451 aa)
	Z520_02199	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (512 aa)
	Z520_03299	Uncharacterized protein. (290 aa)
	Z520_05466	Uncharacterized protein. (283 aa)
	Z520_06245	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (521 aa)
	Z520_06453	Pyruvate carboxyltransferase domain-containing protein. (619 aa)
	Z520_06917	Uncharacterized protein. (575 aa)
	Z520_07184	Uncharacterized protein. (520 aa)
	Z520_07144	Uncharacterized protein. (347 aa)
	Z520_08483	DAO domain-containing protein. (429 aa)
	Z520_09016	Uncharacterized protein. (690 aa)
	Z520_09565	AMP-binding domain-containing protein. (679 aa)
	Z520_09525	Uncharacterized protein. (354 aa)
	Z520_09721	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (291 aa)
	Z520_11406	Zn(2)-C6 fungal-type domain-containing protein. (695 aa)
	Z520_11401	Uncharacterized protein. (406 aa)
	Z520_11356	PKS_ER domain-containing protein. (360 aa)
	Z520_12081	Uncharacterized protein. (543 aa)
	Z520_09411	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (446 aa)
	Z520_04995	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (448 aa)
	Z520_01143	PKS_ER domain-containing protein. (358 aa)
	Z520_10079	AMP-binding domain-containing protein. (702 aa)
	Z520_00264	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (409 aa)
	Z520_03711	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (583 aa)
	Z520_09398	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (501 aa)
	Z520_02398	DAO domain-containing protein. (486 aa)
	Z520_01150	Uncharacterized protein. (330 aa)
	Z520_08268	Uncharacterized protein. (669 aa)
	Z520_00196	Uncharacterized protein. (442 aa)
	Z520_00501	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (275 aa)
	Z520_05239	Uncharacterized protein. (279 aa)
	Z520_05094	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (467 aa)
	Z520_04419	Uncharacterized protein. (582 aa)
	Z520_03979	Pyruvate carboxyltransferase domain-containing protein. (368 aa)
	Z520_02816	Uncharacterized protein. (264 aa)
	Z520_01581	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (528 aa)
	Z520_01721	Uncharacterized protein. (591 aa)
	Z520_00180	Uncharacterized protein. (334 aa)
	Z520_00796	AB hydrolase-1 domain-containing protein. (569 aa)

Your Current Organism:

Fonsecaea multimorphosa

NCBI taxonomy Id: 1442371
Other names: F. multimorphosa CBS 102226, Fonsecaea multimorphosa CBS 102226

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Z520_00077	Z520_00196	A0A0D2HNK3	A0A0D2KJ50	AMP-binding domain-containing protein.	Uncharacterized protein.	0.486
Z520_00077	Z520_00264	A0A0D2HNK3	A0A0D2KBV0	AMP-binding domain-containing protein.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.611
Z520_00077	Z520_00473	A0A0D2HNK3	A0A0D2J2W7	AMP-binding domain-containing protein.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.578
Z520_00077	Z520_00501	A0A0D2HNK3	A0A0D2KK10	AMP-binding domain-containing protein.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.451
Z520_00077	Z520_00658	A0A0D2HNK3	A0A0D2HQ15	AMP-binding domain-containing protein.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.465
Z520_00077	Z520_00925	A0A0D2HNK3	A0A0D2HQV8	AMP-binding domain-containing protein.	Uncharacterized protein.	0.504
Z520_00077	Z520_01150	A0A0D2HNK3	A0A0D2KGT7	AMP-binding domain-containing protein.	Uncharacterized protein.	0.526
Z520_00077	Z520_01457	A0A0D2HNK3	A0A0D2HM94	AMP-binding domain-containing protein.	Fungal_trans domain-containing protein.	0.458
Z520_00077	Z520_01581	A0A0D2HNK3	A0A0D2L215	AMP-binding domain-containing protein.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.445
Z520_00077	Z520_02110	A0A0D2HNK3	A0A0D2IY67	AMP-binding domain-containing protein.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.458
Z520_00077	Z520_02199	A0A0D2HNK3	A0A0D2HJJ3	AMP-binding domain-containing protein.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.445
Z520_00077	Z520_02590	A0A0D2HNK3	A0A0D2HKR7	AMP-binding domain-containing protein.	Aldedh domain-containing protein.	0.458
Z520_00077	Z520_03114	A0A0D2HNK3	A0A0D2IX25	AMP-binding domain-containing protein.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.458
Z520_00077	Z520_03979	A0A0D2HNK3	A0A0D2KU65	AMP-binding domain-containing protein.	Pyruvate carboxyltransferase domain-containing protein.	0.530
Z520_00077	Z520_04282	A0A0D2HNK3	A0A0D2K1C8	AMP-binding domain-containing protein.	Aldedh domain-containing protein.	0.458
Z520_00077	Z520_04418	A0A0D2HNK3	A0A0D2K1N8	AMP-binding domain-containing protein.	Uncharacterized protein.	0.552
Z520_00077	Z520_04419	A0A0D2HNK3	A0A0D2KSS9	AMP-binding domain-containing protein.	Uncharacterized protein.	0.552
Z520_00077	Z520_04594	A0A0D2HNK3	A0A0D2ISM3	AMP-binding domain-containing protein.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.552
Z520_00077	Z520_04670	A0A0D2HNK3	A0A0D2ISS8	AMP-binding domain-containing protein.	Aldedh domain-containing protein.	0.458
Z520_00077	Z520_04995	A0A0D2HNK3	A0A0D2K8H0	AMP-binding domain-containing protein.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.552