(65 nodes) Endonuclease activity network (Aspergillus heteromorphus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A317X4X1	PIN domain-like protein. (745 aa)
	A0A317UTE9	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (353 aa)
	A0A317UUR6	SAE2-domain-containing protein. (753 aa)
	A0A317UXI5	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (726 aa)
	A0A317V0K4	Uncharacterized protein. (364 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (395 aa)
	A0A317V2C6	DBR1-domain-containing protein. (737 aa)
	A0A317V2D6	tRNA_int_end_N2 domain-containing protein. (441 aa)
	A0A317V2V5	Uncharacterized protein. (204 aa)
	A0A317V323	Uncharacterized protein. (399 aa)
	A0A317V374	DNA lyase Apn2. (589 aa)
	A0A317V4N5	Ribonuclease III. (345 aa)
	A0A317V8N6	Uncharacterized protein. (291 aa)
	A0A317V9C2	Uncharacterized protein. (65 aa)
	A0A317V9M7	Endonuclease. (336 aa)
	A0A317VAW3	Uncharacterized protein. (88 aa)
	A0A317VJ25	Zn(2)-C6 fungal-type domain-containing protein. (275 aa)
	A0A317VMY3	Uncharacterized protein. (211 aa)
	A0A317VND9	Guanyl-specific ribonuclease T1. (133 aa)
	A0A317VRU0	Translin. (315 aa)
	A0A317VTK3	Uncharacterized protein. (584 aa)
	A0A317VVX1	Ribonuclease III. (407 aa)
	A0A317VXU3	Dicer-like protein 2-1; Belongs to the helicase family. Dicer subfamily. (1399 aa)
	A0A317W0R9	20S-pre-rRNA D-site endonuclease NOB1; Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm. Belongs to the NOB1 family. (433 aa)
	A0A317W0V7	PIN domain-like protein. (1139 aa)
	SLX1	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (422 aa)
	A0A317W177	NADH pyrophosphatase. (416 aa)
	A0A317W201	RNase III domain-containing protein. (172 aa)
	A0A317W221	Uncharacterized protein. (386 aa)
	A0A317W280	AAA_12 domain-containing protein. (801 aa)
	A0A317W2A3	Smr domain protein. (561 aa)
	A0A317W3Q3	Uncharacterized protein. (545 aa)
	A0A317W6J8	RNB-domain-containing protein; Belongs to the RNR ribonuclease family. (936 aa)
	A0A317W7W4	Piwi-domain-containing protein. (956 aa)
	A0A317W8D3	DRMBL domain-containing protein. (806 aa)
	A0A317WAF7	Putative ribonuclease P complex subunit Pop1. (840 aa)
	A0A317WAQ8	Uncharacterized protein. (405 aa)
	A0A317WAV5	RAI1-domain-containing protein. (368 aa)
	A0A317WB97	Rpr2-domain-containing protein. (202 aa)
	A0A317WGQ2	tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...] (308 aa)
	A0A317WH06	DNA repair protein. (985 aa)
	A0A317WI65	Ydc2-catalyt domain-containing protein. (90 aa)
	A0A317WIJ4	Mating-type switching protein Swi10. (312 aa)
	A0A317WKT4	Nuclease domain protein. (272 aa)
	A0A317WL34	Dicer-like protein 1; Belongs to the helicase family. Dicer subfamily. (1533 aa)
	A0A317WL76	Ribonuclease H-like protein. (274 aa)
	A0A317WMT0	Uncharacterized protein. (65 aa)
	A0A317WNJ7	Kinase-like protein. (1152 aa)
	A0A317WS49	Piwi-domain-containing protein. (996 aa)
	A0A317WSF8	18S rRNA biogenesis protein. (405 aa)
	A0A317WU36	Uncharacterized protein. (814 aa)
	A0A317WUF1	Ribonuclease T2; Belongs to the RNase T2 family. (302 aa)
	A0A317WWN3	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (818 aa)
	A0A317WXC5	UV-endonuclease UvdE. (584 aa)
	A0A317WZ30	tRNA processing endoribonuclease Trz1. (1080 aa)
	A0A317X070	Endonuclease MUS81. (577 aa)
	A0A317X0C1	Uncharacterized protein. (212 aa)
	A0A317X1E5	Cytochrome P450; Belongs to the cytochrome P450 family. (471 aa)
	SLX4	Structure-specific endonuclease subunit SLX4; Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (796 aa)
	A0A317X2T0	Eukaryotic translation initiation factor 2c. (902 aa)
	BO70DRAFT_2188	Exonuclease. (554 aa)
	A0A317X3A2	Uncharacterized protein. (63 aa)
	A0A317X3F7	Uncharacterized protein. (262 aa)
	A0A317X4I7	Ribonuclease T2 family; Belongs to the RNase T2 family. (432 aa)
	A0A317X4T3	Uncharacterized protein. (450 aa)

Your Current Organism:

Aspergillus heteromorphus

NCBI taxonomy Id: 1448321
Other names: A. heteromorphus CBS 117.55, Aspergillus heteromorphus CBS 117.55

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A317UTE9	A0A317V0K4	A0A317UTE9	A0A317V0K4	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	Uncharacterized protein.	0.456
A0A317UTE9	A0A317V374	A0A317UTE9	A0A317V374	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	DNA lyase Apn2.	0.456
A0A317UTE9	A0A317W0V7	A0A317UTE9	A0A317W0V7	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	PIN domain-like protein.	0.586
A0A317UTE9	A0A317WH06	A0A317UTE9	A0A317WH06	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	DNA repair protein.	0.561
A0A317UTE9	A0A317WL76	A0A317UTE9	A0A317WL76	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	Ribonuclease H-like protein.	0.946
A0A317UTE9	A0A317WZ30	A0A317UTE9	A0A317WZ30	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	tRNA processing endoribonuclease Trz1.	0.574
A0A317UTE9	A0A317X070	A0A317UTE9	A0A317X070	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	Endonuclease MUS81.	0.502
A0A317UTE9	A0A317X4T3	A0A317UTE9	A0A317X4T3	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	Uncharacterized protein.	0.994
A0A317UTE9	A0A317X4X1	A0A317UTE9	A0A317X4X1	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	PIN domain-like protein.	0.765
A0A317UTE9	BO70DRAFT_2188	A0A317UTE9	A0A317X380	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	Exonuclease.	0.586
A0A317UTE9	FEN1	A0A317UTE9	A0A317V0N1	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.766
A0A317UUR6	A0A317UXI5	A0A317UUR6	A0A317UXI5	SAE2-domain-containing protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.922
A0A317UUR6	A0A317W280	A0A317UUR6	A0A317W280	SAE2-domain-containing protein.	AAA_12 domain-containing protein.	0.664
A0A317UUR6	A0A317W3Q3	A0A317UUR6	A0A317W3Q3	SAE2-domain-containing protein.	Uncharacterized protein.	0.671
A0A317UUR6	A0A317WH06	A0A317UUR6	A0A317WH06	SAE2-domain-containing protein.	DNA repair protein.	0.436
A0A317UUR6	A0A317WIJ4	A0A317UUR6	A0A317WIJ4	SAE2-domain-containing protein.	Mating-type switching protein Swi10.	0.450
A0A317UUR6	A0A317X070	A0A317UUR6	A0A317X070	SAE2-domain-containing protein.	Endonuclease MUS81.	0.630
A0A317UUR6	A0A317X4X1	A0A317UUR6	A0A317X4X1	SAE2-domain-containing protein.	PIN domain-like protein.	0.855
A0A317UUR6	BO70DRAFT_2188	A0A317UUR6	A0A317X380	SAE2-domain-containing protein.	Exonuclease.	0.503
A0A317UUR6	FEN1	A0A317UUR6	A0A317V0N1	SAE2-domain-containing protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.766