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| | KALB_1022 | ATP-dependent DNA helicase; Belongs to the helicase family. UvrD subfamily. (1067 aa) |
| | KALB_1023 | UvrD/REP helicase; Belongs to the helicase family. UvrD subfamily. (1175 aa) |
| | KALB_1093 | Putative DNA helicase II-like protein; Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair (By similarity). (695 aa) |
| | KALB_1344 | Hypothetical protein. (627 aa) |
| | KALB_1499 | Hypothetical protein. (148 aa) |
| | KALB_1540 | Putative DNA glycosylase; Involved in base excision repair of DNA damagedby oxidation or by mutagenic agents. Acts as DNAglycosylase that recognizes and removes damaged bases. HasAP (apurinic/apyrimidinic) lyase activity and introducesnicks in the DNA strand. Cleaves the DNA backbone bybeta-delta elimination to generate a single-strand breakat the site of the removed base with both 3'- and5'-phosphates (By similarity); Belongs to the FPG family. (268 aa) |
| | KALB_1575 | Exonuclease RNase T and DNA polymerase III. (253 aa) |
| | KALB_1615 | Superfamily II DNA helicase. (703 aa) |
| | KALB_1635 | Hypothetical protein; DNA polymerase III, delta subunit. (326 aa) |
| | recO | DNA repair protein recO; Involved in DNA repair and RecF pathway recombination. (265 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (631 aa) |
| | KALB_192 | ABC transporter ATP-binding protein. (752 aa) |
| | KALB_1976 | Hypothetical protein. (572 aa) |
| | KALB_2 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (378 aa) |
| | dnaX | DNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (700 aa) |
| | recR | Recombination protein recR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (198 aa) |
| | KALB_2544 | Exonuclease, RNase T and DNA polymerase III. (408 aa) |
| | KALB_2571 | Hypothetical protein. (191 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (901 aa) |
| | uvrB | UvrABC system protein B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and [...] (716 aa) |
| | KALB_2628 | DNA polymerase LigD, ligase domain-containing protein. (349 aa) |
| | KALB_2772 | Putative primosomal protein N; Recognizes a specific hairpin sequence on phiX ssDNA. This structure is then recognized and bound by proteins priB and priC. Formation of the primosome proceeds with the subsequent actions of dnaB, dnaC, dnaT and primase. PriA then functions as a helicase within the primosome (By similarity). (624 aa) |
| | uvrC | UvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (657 aa) |
| | KALB_301 | DNA polymerase III subunit beta. (363 aa) |
| | nth | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (267 aa) |
| | topA | DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (947 aa) |
| | KALB_337 | DNA polymerase III, delta' subunit; ATPase involved in DNA replication. (398 aa) |
| | KALB_396 | A/G-specific adenine glycosylase. (290 aa) |
| | recF | DNA replication and repair protein recF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (384 aa) |
| | radA | DNA repair RadA-like protein; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (461 aa) |
| | KALB_4357 | Hypothetical protein. (1003 aa) |
| | KALB_4455 | Hypothetical protein. (304 aa) |
| | KALB_4682 | Hypothetical protein. (345 aa) |
| | KALB_4863 | Hypothetical protein. (389 aa) |
| | KALB_5 | Hypothetical protein; Zn-ribbon-containing, possibly RNA-binding protein; Belongs to the UPF0232 family. (218 aa) |
| | KALB_5043 | Hypothetical protein. (627 aa) |
| | KALB_565 | Hypothetical protein. (256 aa) |
| | KALB_5854 | Hypothetical protein. (765 aa) |
| | gyrB | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (657 aa) |
| | lexA | Hypothetical protein; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (220 aa) |
| | KALB_6439 | Hypothetical protein; May be involved in recombinational repair of damaged DNA. (592 aa) |
| | uvrA | Hypothetical protein; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (952 aa) |
| | ruvB | Hypothetical protein; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (348 aa) |
| | ruvA | Hypothetical protein; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (200 aa) |
| | ruvC | Hypothetical protein; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (191 aa) |
| | recX | Hypothetical protein; Modulates RecA activity; Belongs to the RecX family. (174 aa) |
| | recA | Hypothetical protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (347 aa) |
| | KALB_6717 | Hypothetical protein. (1528 aa) |
| | KALB_6787 | Hypothetical protein. (338 aa) |
| | gyrA | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (839 aa) |
| | KALB_7084 | Hypothetical protein. (1184 aa) |
| | dinB | Hypothetical protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (428 aa) |
| | KALB_7146 | Hypothetical protein; Belongs to the FPG family. (274 aa) |
| | mutM | Hypothetical protein; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (288 aa) |
| | ung | Hypothetical protein; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (225 aa) |
| | ligA | Hypothetical protein; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (707 aa) |
| | mfd | Transcription-repair-coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1194 aa) |
| | KALB_8048 | Hypothetical protein. (265 aa) |
| | KALB_8127 | Hypothetical protein. (787 aa) |
| | KALB_8760 | Hypothetical protein. (163 aa) |
| | KALB_8763 | Hypothetical protein; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (453 aa) |
| | KALB_8792 | Hypothetical protein. (292 aa) |
| | lig | Putative DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (513 aa) |
| | sbcD | Putative ATP-dependent dsDNA exonuclease; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (375 aa) |
| | KALB_900 | Putative ATP-dependent dsDNA exonuclease; ATPase involved in DNA repair. (975 aa) |
| | KALB_91 | formamidopyrimidine-DNA glycosylase; Belongs to the FPG family. (288 aa) |
