STRINGSTRING
atpB-2 atpB-2 KALB_1021 KALB_1021 KALB_1083 KALB_1083 KALB_1284 KALB_1284 KALB_134 KALB_134 KALB_1369 KALB_1369 KALB_1550 KALB_1550 KALB_1552 KALB_1552 ndk ndk KALB_1664 KALB_1664 KALB_173 KALB_173 KALB_1763 KALB_1763 KALB_1819 KALB_1819 KALB_1850 KALB_1850 KALB_1940 KALB_1940 pfp pfp KALB_1997 KALB_1997 coaA coaA KALB_2176 KALB_2176 KALB_2249 KALB_2249 KALB_240 KALB_240 KALB_2497 KALB_2497 coaE coaE KALB_2701 KALB_2701 KALB_2730 KALB_2730 pyrB pyrB pyrC pyrC KALB_2753 KALB_2753 carA carA carB carB pyrF pyrF KALB_2760 KALB_2760 KALB_2762 KALB_2762 KALB_2801 KALB_2801 pgk pgk tpiA tpiA KALB_2810 KALB_2810 KALB_2929 KALB_2929 KALB_2936 KALB_2936 KALB_3067 KALB_3067 KALB_3069 KALB_3069 acsA acsA KALB_3211 KALB_3211 KALB_3349 KALB_3349 KALB_3394 KALB_3394 KALB_3448 KALB_3448 KALB_3518 KALB_3518 ackA ackA KALB_360 KALB_360 KALB_3637 KALB_3637 KALB_3655 KALB_3655 coaX coaX KALB_3789 KALB_3789 atpB atpB KALB_3917 KALB_3917 KALB_3980 KALB_3980 KALB_4030 KALB_4030 KALB_4050 KALB_4050 KALB_4090 KALB_4090 KALB_4142 KALB_4142 KALB_4144 KALB_4144 KALB_4145 KALB_4145 KALB_4147 KALB_4147 KALB_4168 KALB_4168 KALB_4169 KALB_4169 pdhA pdhA KALB_4172 KALB_4172 KALB_4183 KALB_4183 KALB_4339 KALB_4339 KALB_4370 KALB_4370 KALB_4387 KALB_4387 KALB_4442 KALB_4442 KALB_4446 KALB_4446 KALB_4553 KALB_4553 KALB_4640 KALB_4640 KALB_4688 KALB_4688 KALB_4997 KALB_4997 KALB_5149 KALB_5149 KALB_5456 KALB_5456 KALB_5554 KALB_5554 coaD coaD KALB_5668 KALB_5668 KALB_5810 KALB_5810 KALB_5995 KALB_5995 KALB_6003 KALB_6003 KALB_6415 KALB_6415 KALB_6435 KALB_6435 pyrG pyrG KALB_6456 KALB_6456 KALB_6465 KALB_6465 KALB_6512 KALB_6512 KALB_6600 KALB_6600 KALB_6601 KALB_6601 KALB_67 KALB_67 KALB_690 KALB_690 KALB_7013 KALB_7013 KALB_7014 KALB_7014 pyrD pyrD KALB_719 KALB_719 KALB_7197 KALB_7197 KALB_7295 KALB_7295 pyrH pyrH coaD-2 coaD-2 KALB_7434 KALB_7434 KALB_7494 KALB_7494 KALB_7588 KALB_7588 atpC atpC atpD atpD atpG atpG atpA atpA atpH atpH atpF atpF atpE atpE atpB-3 atpB-3 KALB_7721 KALB_7721 prs prs KALB_7932 KALB_7932 purE purE purK purK KALB_799 KALB_799 upp upp eno eno KALB_8077 KALB_8077 purH purH KALB_8103 KALB_8103 guaA guaA guaB guaB adk adk KALB_8274 KALB_8274 KALB_8368 KALB_8368 gpmA gpmA purU purU KALB_8407 KALB_8407 KALB_8484 KALB_8484 KALB_8532 KALB_8532 purM purM purF purF purL purL purQ purQ purS purS purC purC KALB_8571 KALB_8571 purD purD purA purA KALB_8605 KALB_8605 KALB_863 KALB_863 KALB_8633 KALB_8633 pyrE pyrE KALB_8645 KALB_8645 KALB_8661 KALB_8661 KALB_8689 KALB_8689 KALB_8691 KALB_8691
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
atpB-2Hypothetical protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. (493 aa)
KALB_1021Hypothetical protein. (262 aa)
KALB_1083Glutamine amidotransferase class-I/GMP synthase. (250 aa)
KALB_1284Protein of unknown function UPF0157. (260 aa)
KALB_134Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. (208 aa)
KALB_1369AMP-dependent synthetase and ligase. (563 aa)
KALB_1550Flavoprotein. (181 aa)
KALB_1552Hypothetical protein. (117 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (136 aa)
KALB_1664Hypothetical protein. (151 aa)
KALB_173GCN5-related N-acetyltransferase. (220 aa)
KALB_1763Hypothetical protein. (417 aa)
KALB_1819AMP-dependent synthetase and ligase. (515 aa)
KALB_1850Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (925 aa)
KALB_1940The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). (582 aa)
pfpPyrophosphate--fructose 6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (341 aa)
KALB_1997Putative ribose-phosphate pyrophosphokinase. (321 aa)
coaAPantothenate kinase. (308 aa)
KALB_2176LigA protein. (423 aa)
KALB_22492-amino-4,5-dihydroxy-6-one-heptanoic acid-7-phosphate synthase; Catalyzes aldol condensation between L-aspartate-4- semialdehyde (ASA) and dihydroxyacetone phosphate (DHAP), to form 2-amino-4,5-dihydroxy-6-one-heptanoic acid-7-phosphate. (275 aa)
KALB_240Hypothetical protein. (153 aa)
KALB_2497Phosphoglycerate mutase family protein; Fructose-2,6-bisphosphatase. (218 aa)
coaEDephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (392 aa)
KALB_2701Uridine kinase-like protein. (214 aa)
KALB_2730ATP-binding protein. (422 aa)
pyrBAspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (310 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (437 aa)
KALB_2753Putative membrane protein. (173 aa)
carACarbamoyl-phosphate synthase small chain; Belongs to the CarA family. (373 aa)
carBCarbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1100 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (276 aa)
KALB_2760Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (169 aa)
KALB_2762Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (417 aa)
KALB_2801Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (412 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (261 aa)
KALB_2810Glucose-6-phosphate isomerase; Belongs to the GPI family. (539 aa)
KALB_2929Hypothetical protein. (115 aa)
KALB_2936Glyoxalase. (137 aa)
KALB_3067Pyruvate dehydrogenase E1 protein subunit alpha. (365 aa)
KALB_3069Branched-chain alpha-keto acid dehydrogenase subunit E2. (402 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (656 aa)
KALB_3211Purine phosphoribosyltransferase. (173 aa)
KALB_3349Hypothetical protein. (241 aa)
KALB_3394Hypothetical protein. (126 aa)
KALB_3448Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. (522 aa)
KALB_3518Hypothetical protein. (187 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (362 aa)
KALB_360Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (182 aa)
KALB_3637Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
KALB_3655L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. (318 aa)
coaXType III pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (257 aa)
KALB_3789Hypothetical protein. (219 aa)
atpBATP synthase A chain; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (256 aa)
KALB_3917Glyoxalase/bleomycin resistance protein/dioxygenase. (117 aa)
KALB_3980Hypothetical protein. (118 aa)
KALB_4030Hypothetical protein. (126 aa)
KALB_4050Hypothetical protein. (114 aa)
KALB_4090Hypothetical protein. (249 aa)
KALB_4142Hypothetical protein. (141 aa)
KALB_4144Hypothetical protein. (169 aa)
KALB_4145Hypothetical protein. (572 aa)
KALB_4147Hypothetical protein. (153 aa)
KALB_4168Hypothetical protein. (305 aa)
KALB_4169Hypothetical protein. (587 aa)
pdhAHypothetical protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (331 aa)
KALB_4172Hypothetical protein. (432 aa)
KALB_4183Hypothetical protein. (598 aa)
KALB_4339Hypothetical protein. (238 aa)
KALB_4370Hypothetical protein. (229 aa)
KALB_4387Hypothetical protein. (142 aa)
KALB_4442Hypothetical protein. (423 aa)
KALB_4446Hypothetical protein. (402 aa)
KALB_4553Hypothetical protein. (140 aa)
KALB_4640Hypothetical protein. (257 aa)
KALB_4688Hypothetical protein. (174 aa)
KALB_4997Hypothetical protein. (113 aa)
KALB_5149Hypothetical protein. (449 aa)
KALB_5456Hypothetical protein. (334 aa)
KALB_5554Hypothetical protein; Catalyzes the conversion of dihydroorotate to orotate. (287 aa)
coaDHypothetical protein; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (136 aa)
KALB_5668Hypothetical protein. (122 aa)
KALB_5810Hypothetical protein. (324 aa)
KALB_5995Hypothetical protein. (250 aa)
KALB_6003Hypothetical protein. (238 aa)
KALB_6415Hypothetical protein. (209 aa)
KALB_6435Hypothetical protein. (211 aa)
pyrGHypothetical protein; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (565 aa)
KALB_6456Hypothetical protein. (267 aa)
KALB_6465Hypothetical protein. (129 aa)
KALB_6512Hypothetical protein. (236 aa)
KALB_6600Hypothetical protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (766 aa)
KALB_6601Hypothetical protein. (151 aa)
KALB_67Pyruvate dehydrogenase E1 component. (781 aa)
KALB_690Nucleoside diphosphate kinase; Belongs to the NDK family. (169 aa)
KALB_7013Hypothetical protein. (314 aa)
KALB_7014Hypothetical protein; Belongs to the pyruvate kinase family. (464 aa)
pyrDHypothetical protein; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (342 aa)
KALB_719Hypothetical protein. (220 aa)
KALB_7197Hypothetical protein; Belongs to the ribF family. (311 aa)
KALB_7295Hypothetical protein. (263 aa)
pyrHHypothetical protein; Catalyzes the reversible phosphorylation of UMP to UDP. (251 aa)
coaD-2Hypothetical protein; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa)
KALB_7434Hypothetical protein. (217 aa)
KALB_7494Hypothetical protein. (266 aa)
KALB_7588Hypothetical protein. (260 aa)
atpCHypothetical protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. (121 aa)
atpDHypothetical protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (477 aa)
atpGHypothetical protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (308 aa)
atpAHypothetical protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (548 aa)
atpHHypothetical protein; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (277 aa)
atpFHypothetical protein; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (180 aa)
atpEHypothetical protein; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (73 aa)
atpB-3Hypothetical protein; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (260 aa)
KALB_7721Hypothetical protein. (252 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (326 aa)
KALB_7932Hypothetical protein. (237 aa)
purEHypothetical protein; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (163 aa)
purKHypothetical protein; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (386 aa)
KALB_799Nucleoside-triphosphate pyrophosphatase. (321 aa)
uppHypothetical protein; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (207 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa)
KALB_8077Hypothetical protein. (123 aa)
purHHypothetical protein. (519 aa)
KALB_8103Hypothetical protein. (185 aa)
guaAHypothetical protein; Catalyzes the synthesis of GMP from XMP. (520 aa)
guaBHypothetical protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (503 aa)
adkHypothetical protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (183 aa)
KALB_8274Hypothetical protein. (476 aa)
KALB_8368Hypothetical protein. (281 aa)
gpmAHypothetical protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (245 aa)
purUHypothetical protein; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (283 aa)
KALB_8407Hypothetical protein. (119 aa)
KALB_8484Hypothetical protein. (115 aa)
KALB_8532Hypothetical protein. (296 aa)
purMHypothetical protein. (359 aa)
purFHypothetical protein; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (511 aa)
purLHypothetical protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the am [...] (762 aa)
purQHypothetical protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the am [...] (224 aa)
purSHypothetical protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the am [...] (79 aa)
purCHypothetical protein; Belongs to the SAICAR synthetase family. (291 aa)
KALB_8571Hypothetical protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (477 aa)
purDHypothetical protein; Belongs to the GARS family. (419 aa)
purAHypothetical protein; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa)
KALB_8605Hypothetical protein; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (343 aa)
KALB_863Hypothetical protein. (202 aa)
KALB_8633Hypothetical protein. (204 aa)
pyrEHypothetical protein; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (183 aa)
KALB_8645Hypothetical protein. (219 aa)
KALB_8661Hypothetical protein. (247 aa)
KALB_8689Hypothetical protein. (447 aa)
KALB_8691Hypothetical protein. (398 aa)
Your Current Organism:
Kutzneria albida
NCBI taxonomy Id: 1449976
Other names: K. albida DSM 43870, Kutzneria albida DSM 43870
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