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| | alaS | Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (887 aa) |
| | glgC | Glucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (405 aa) |
| | KALB_921 | GTP-binding TypA/BipA-like protein; Not known; probably interacts with the ribosomes in a GTP dependent manner (By similarity). (635 aa) |
| | KALB_919 | Tryptophanyl-tRNA synthetase 2; Belongs to the class-I aminoacyl-tRNA synthetase family. (321 aa) |
| | KALB_889 | Hypothetical protein. (203 aa) |
| | rpmH | Hypothetical protein; Belongs to the bacterial ribosomal protein bL34 family. (47 aa) |
| | KALB_8833 | Hypothetical protein; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (310 aa) |
| | KALB_8823 | Hypothetical protein. (547 aa) |
| | leuS | Hypothetical protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (947 aa) |
| | KALB_8784 | Hypothetical protein; Belongs to the amidase family. (474 aa) |
| | rplI | Hypothetical protein; Binds to the 23S rRNA. (151 aa) |
| | rpsR-2 | Hypothetical protein; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (80 aa) |
| | rpsF | Hypothetical protein; Binds together with S18 to 16S ribosomal RNA. (98 aa) |
| | KALB_8542 | Hypothetical protein. (142 aa) |
| | KALB_8477 | Hypothetical protein. (581 aa) |
| | KALB_8449 | Hypothetical protein. (404 aa) |
| | KALB_8445 | Hypothetical protein. (105 aa) |
| | KALB_8442 | Hypothetical protein. (398 aa) |
| | KALB_8429 | Hypothetical protein. (164 aa) |
| | KALB_8426 | Hypothetical protein. (274 aa) |
| | KALB_8425 | Hypothetical protein. (441 aa) |
| | KALB_8424 | Hypothetical protein. (320 aa) |
| | KALB_8422 | Hypothetical protein. (488 aa) |
| | KALB_841 | Putative membrane protein. (402 aa) |
| | murB-2 | Hypothetical protein; Cell wall formation. (366 aa) |
| | KALB_8385 | Hypothetical protein. (388 aa) |
| | KALB_8268 | Hypothetical protein; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (293 aa) |
| | rpmG-2 | Hypothetical protein; Belongs to the bacterial ribosomal protein bL33 family. (54 aa) |
| | rplK-2 | Hypothetical protein; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (144 aa) |
| | rplA | Hypothetical protein; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (238 aa) |
| | rplJ | Hypothetical protein; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (181 aa) |
| | rplL | Hypothetical protein; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (128 aa) |
| | rpsL | Hypothetical protein; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. (124 aa) |
| | rpsG | Hypothetical protein; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa) |
| | fusA | Hypothetical protein; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (699 aa) |
| | tuf | Hypothetical protein; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (397 aa) |
| | rpsJ | Hypothetical protein; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (101 aa) |
| | rplC | Hypothetical protein; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (216 aa) |
| | rplD | Hypothetical protein; Forms part of the polypeptide exit tunnel. (228 aa) |
| | rplW | Hypothetical protein; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (99 aa) |
| | rplB | Hypothetical protein; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (277 aa) |
| | rpsS | Hypothetical protein; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (93 aa) |
| | rplV | Hypothetical protein; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (141 aa) |
| | rpsC | Hypothetical protein; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (276 aa) |
| | rplP | Hypothetical protein; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (139 aa) |
| | rpmC | Hypothetical protein; Belongs to the universal ribosomal protein uL29 family. (82 aa) |
| | rpsQ | Hypothetical protein; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (92 aa) |
| | rplN | Hypothetical protein; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa) |
| | rplX | Hypothetical protein; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (104 aa) |
| | rplE | Hypothetical protein; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (187 aa) |
| | rpsZ | Hypothetical protein; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa) |
| | rpsH | Hypothetical protein; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa) |
| | rplF | Hypothetical protein; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (179 aa) |
| | rplR | Hypothetical protein; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (133 aa) |
| | rpsE | Hypothetical protein; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (202 aa) |
| | rpmD | Hypothetical protein. (60 aa) |
| | rplO | Hypothetical protein; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (147 aa) |
| | infA-2 | Hypothetical protein; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (73 aa) |
| | rpmJ | Hypothetical protein; Belongs to the bacterial ribosomal protein bL36 family. (37 aa) |
| | rpsM | Hypothetical protein; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (126 aa) |
| | rpsK | Hypothetical protein; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (135 aa) |
| | rpsD | Hypothetical protein; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (201 aa) |
| | rplQ | Hypothetical protein. (178 aa) |
| | rplM | Hypothetical protein; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (147 aa) |
| | rpsI | Hypothetical protein; Belongs to the universal ribosomal protein uS9 family. (182 aa) |
| | KALB_8043 | Hypothetical protein. (421 aa) |
| | KALB_8042 | Hypothetical protein. (80 aa) |
| | KALB_7925 | Hypothetical protein. (836 aa) |
| | KALB_7922 | Hypothetical protein. (295 aa) |
| | KALB_7919 | Hypothetical protein. (293 aa) |
| | KALB_7910 | Hypothetical protein. (1117 aa) |
| | glmU | Bifunctional protein glmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (494 aa) |
| | rplY | 50S ribosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (200 aa) |
| | KALB_7854 | Hypothetical protein. (200 aa) |
| | pth | Peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. (190 aa) |
| | metG | Methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (597 aa) |
| | KALB_772 | Glycosyltransferase. (529 aa) |
| | KALB_7701 | Hypothetical protein. (160 aa) |
| | argS-2 | Hypothetical protein. (558 aa) |
| | rpmE | Hypothetical protein; Binds the 23S rRNA. (70 aa) |
| | prfA | Hypothetical protein; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (361 aa) |
| | KALB_7615 | Hypothetical protein. (389 aa) |
| | murA | Hypothetical protein; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (422 aa) |
| | KALB_7507 | Hypothetical protein. (399 aa) |
| | glgB | Hypothetical protein; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. (722 aa) |
| | KALB_7505 | Hypothetical protein. (447 aa) |
| | glgE | Hypothetical protein; Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1->4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB. (656 aa) |
| | KALB_7483 | Hypothetical protein; Belongs to the glycosyl hydrolase 57 family. (502 aa) |
| | KALB_7441 | Hypothetical protein. (297 aa) |
| | gatC | Hypothetical protein; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (99 aa) |
| | gatA | Hypothetical protein; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (506 aa) |
| | gatB | Hypothetical protein; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (501 aa) |
| | KALB_7404 | Hypothetical protein. (93 aa) |
| | ddl-2 | Hypothetical protein; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (362 aa) |
| | rpmB-2 | Hypothetical protein; Belongs to the bacterial ribosomal protein bL28 family. (63 aa) |
| | rpmF-2 | Hypothetical protein; Belongs to the bacterial ribosomal protein bL32 family. (60 aa) |
| | rpsP | Hypothetical protein; Belongs to the bacterial ribosomal protein bS16 family. (155 aa) |
| | KALB_7314 | Hypothetical protein; Belongs to the UPF0109 family. (79 aa) |
| | rplS | Hypothetical protein; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (119 aa) |
| | rpsB | Hypothetical protein; Belongs to the universal ribosomal protein uS2 family. (277 aa) |
| | KALB_73 | Putative membrane protein. (322 aa) |
| | tsf | Hypothetical protein; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (269 aa) |
| | frr | Hypothetical protein; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (185 aa) |
| | infB | Hypothetical protein; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (611 aa) |
| | KALB_72 | Hypothetical protein. (380 aa) |
| | rpsO | Hypothetical protein; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (89 aa) |
| | rpmF | Hypothetical protein; Belongs to the bacterial ribosomal protein bL32 family. (53 aa) |
| | rpmE2 | Hypothetical protein. (84 aa) |
| | rpmB | Hypothetical protein; Belongs to the bacterial ribosomal protein bL28 family. (78 aa) |
| | rpmG | Hypothetical protein; Belongs to the bacterial ribosomal protein bL33 family. (54 aa) |
| | rpsN | Hypothetical protein; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (101 aa) |
| | rpsR | Hypothetical protein; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (79 aa) |
| | murE | Hypothetical protein; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (527 aa) |
| | murF | Hypothetical protein; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (482 aa) |
| | mraY-2 | Hypothetical protein; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (365 aa) |
| | murD | Hypothetical protein; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (450 aa) |
| | KALB_7114 | Hypothetical protein; Belongs to the SEDS family. (495 aa) |
| | murG-2 | Hypothetical protein; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (366 aa) |
| | murC | Hypothetical protein; Cell wall formation; Belongs to the MurCDEF family. (458 aa) |
| | ileS | Hypothetical protein; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1040 aa) |
| | lgt | Hypothetical protein; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. (339 aa) |
| | KALB_7015 | Hypothetical protein. (508 aa) |
| | uppP | Hypothetical protein; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (326 aa) |
| | KALB_70 | Glycosyl transferase family 2. (641 aa) |
| | KALB_68 | Hypothetical protein. (438 aa) |
| | KALB_6792 | Hypothetical protein. (250 aa) |
| | KALB_663 | Putative membrane protein. (178 aa) |
| | KALB_6626 | Hypothetical protein; Belongs to the peptidase S11 family. (415 aa) |
| | KALB_6592 | Hypothetical protein; Belongs to the class-II aminoacyl-tRNA synthetase family. (421 aa) |
| | acuS3 | dTDP-4-dehydrorhamnose 3,5-epimerase. (201 aa) |
| | acuS6 | Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (288 aa) |
| | acuX1 | AcuX1; Belongs to the class-I aminoacyl-tRNA synthetase family. (566 aa) |
| | KALB_6497 | Putative acyltransferase 3. (377 aa) |
| | KALB_6477 | Hypothetical protein. (487 aa) |
| | infC | Hypothetical protein; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (204 aa) |
| | rpmI | Hypothetical protein; Belongs to the bacterial ribosomal protein bL35 family. (64 aa) |
| | rplT | Hypothetical protein; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (124 aa) |
| | pheS | Hypothetical protein; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (355 aa) |
| | pheT | Hypothetical protein; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (826 aa) |
| | tyrS | Hypothetical protein; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (424 aa) |
| | KALB_6404 | Hypothetical protein. (646 aa) |
| | KALB_6299 | Hypothetical protein. (541 aa) |
| | KALB_6274 | Hypothetical protein. (682 aa) |
| | argS | Hypothetical protein. (580 aa) |
| | KALB_6243 | Hypothetical protein. (408 aa) |
| | KALB_6156 | Hypothetical protein. (487 aa) |
| | KALB_6096 | Hypothetical protein. (148 aa) |
| | KALB_5912 | Hypothetical protein. (443 aa) |
| | KALB_5837 | Hypothetical protein. (526 aa) |
| | KALB_5757 | Hypothetical protein. (397 aa) |
| | KALB_5680 | Hypothetical protein. (202 aa) |
| | gltX | Hypothetical protein; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (525 aa) |
| | KALB_5678 | Hypothetical protein. (127 aa) |
| | KALB_5660 | Hypothetical protein. (275 aa) |
| | KALB_5612 | Hypothetical protein. (540 aa) |
| | KALB_5584 | Hypothetical protein. (431 aa) |
| | KALB_5504 | Hypothetical protein. (364 aa) |
| | KALB_5349 | Hypothetical protein. (131 aa) |
| | KALB_5239 | Hypothetical protein. (983 aa) |
| | def-3 | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (193 aa) |
| | KALB_5098 | Hypothetical protein. (406 aa) |
| | KALB_5006 | Hypothetical protein. (532 aa) |
| | KALB_4987 | Hypothetical protein. (267 aa) |
| | KALB_4986 | Hypothetical protein. (228 aa) |
| | lnt | Hypothetical protein; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. (532 aa) |
| | KALB_4393 | Hypothetical protein. (103 aa) |
| | KALB_4372 | Hypothetical protein; Belongs to the amidase family. (470 aa) |
| | KALB_4347 | Hypothetical protein; Belongs to the amidase family. (445 aa) |
| | KALB_4314 | Hypothetical protein. (470 aa) |
| | KALB_4311 | Hypothetical protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (472 aa) |
| | KALB_4307 | Hypothetical protein. (188 aa) |
| | cysS | Cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (463 aa) |
| | KALB_419 | Putative poly(beta-D-mannuronate) O-acetylase; Together with AlgV and AlgF, forms an inner membrane complex which probably interacts with the alginate polymerization- transport complex and adds acetyl groups at the O-2 and O-3 positions of polymannuronic acid. Acetylation of alginate increases cyst resistance to desiccation; Belongs to the membrane-bound acyltransferase family. (474 aa) |
| | infA | Hypothetical protein; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (74 aa) |
| | KALB_4037 | Hypothetical protein. (784 aa) |
| | KALB_3931 | Secreted protein. (277 aa) |
| | KALB_3850 | Acyltransferase. (384 aa) |
| | KALB_3790 | Methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity). (490 aa) |
| | lysS-2 | Lysyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (474 aa) |
| | KALB_3781 | phenylalanyl-tRNA synthetase, alpha subunit. (369 aa) |
| | KALB_3756 | ABC transporter. (542 aa) |
| | KALB_3716 | Hypothetical protein. (551 aa) |
| | KALB_3713 | MviN-like protein. (542 aa) |
| | KALB_3594 | Putative membrane protein. (220 aa) |
| | KALB_3530 | UDP-N-acetylmuramyl tripeptide synthase. (451 aa) |
| | KALB_3529 | Glutamine amidotransferase. (249 aa) |
| | rplK | 50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (141 aa) |
| | KALB_3271 | Amidase; Belongs to the amidase family. (473 aa) |
| | KALB_3181 | Glycosyltransferase. (517 aa) |
| | KALB_3156 | Glycosyltransferase. (525 aa) |
| | mraY | Phospho-N-acetylmuramoyl-pentapeptide-transferas e; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (366 aa) |
| | KALB_2898 | Glycosyl transferase. (582 aa) |
| | fmt | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (308 aa) |
| | def-2 | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (161 aa) |
| | KALB_2759 | Hypothetical protein. (105 aa) |
| | efp | Elongation factor P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. (187 aa) |
| | mltG | Aminodeoxychorismate lyase-like secreted solute-binding protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (399 aa) |
| | aspS | Aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (595 aa) |
| | KALB_268 | Hypothetical protein. (387 aa) |
| | KALB_2648 | ABC transporter. (539 aa) |
| | KALB_2618 | 30S ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity). (488 aa) |
| | KALB_2583 | Hypothetical protein. (497 aa) |
| | KALB_2564 | Threonyl-tRNA synthetase. (405 aa) |
| | KALB_2518 | Hypothetical protein. (506 aa) |
| | thrS | Threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (683 aa) |
| | KALB_2405 | Hypothetical protein. (439 aa) |
| | KALB_2330 | Hypothetical protein. (269 aa) |
| | KALB_23 | Penicillin-binding protein A; Cell wall formation. Plays an important role incell division and cell shape maintenance by cross-linkingadjacent peptidoglycan chains through transpeptidation. (495 aa) |
| | KALB_2242 | Hypothetical protein. (314 aa) |
| | KALB_2225 | Putative secreted protein. (124 aa) |
| | KALB_2071 | Putative endo alpha-1,4 polygalactosaminidase. (311 aa) |
| | KALB_2027 | Hypothetical protein. (125 aa) |
| | KALB_2025 | Hypothetical protein. (243 aa) |
| | KALB_2024 | Hypothetical protein. (418 aa) |
| | murB | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (371 aa) |
| | KALB_1826 | Tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (352 aa) |
| | KALB_1792 | Integral membrane protein. (721 aa) |
| | glyQS | Glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (465 aa) |
| | KALB_166 | UDP-galactofuranosyl transferase GlfT1; Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. It catalyzes the transfer of the first galactofuranosyl (Galf) unit from UDP- galactofuranosyl (UDP-Galf) onto the rhamnosyl-GlcNAc- pyrophosphoryl-undecaprenyl (Rha-GlcNAc-PP-C55) acceptor through a beta-D-(1->5) or a beta-D-(1->6) galactofuranosyltransferase activitie, yielding galactofuranosyl-rhamnosyl-GlcNAc- pyrophosphoryl-undecaprenyl (Galf-Rha-GlcNAc-PP-C55). GlfT1 [...] (301 aa) |
| | lepA | Elongation factor 4; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (614 aa) |
| | KALB_165 | UDP-galactofuranosyl transferase GlfT2; Involved in the polymerization of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacteria cell wall, through successively beta-D-(1->5) and beta-D-(1->6)- galactofuranosyltransferases activities. It transfers the galactofuranosyl (Galf) unit from UDP-galactofuranosyl (UDP-Galf) onto the galactofuranosyl-rhamnosyl-GlcNAc-pyrophosphoryl- undecaprenyl (Galf-Rha-GlcNAc-PP-C55), yielding polygalactofuranosyl-rhamnosyl-GlcNAc-pyrophosphoryl- undecaprenyl ((Galf)x-Rha-GlcNAc-PP- [...] (643 aa) |
| | KALB_164 | UDP-galactopyranose mutase; Involved in the conversion of UDP-GalP into UDP-GalF through a 2-keto intermediate. (408 aa) |
| | rpsT | Hypothetical protein; Binds directly to 16S ribosomal RNA. (87 aa) |
| | rpmA | Hypothetical protein; Belongs to the bacterial ribosomal protein bL27 family. (90 aa) |
| | rplU | Hypothetical protein; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (102 aa) |
| | valS-2 | Valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner. (828 aa) |
| | valS | Valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (877 aa) |
| | KALB_158 | Hypothetical protein. (415 aa) |
| | KALB_1565 | Formyltransferase. (315 aa) |
| | proS | Prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (582 aa) |
| | KALB_1500 | Putative ABC transporter ATP-binding protein; Probably part of an ABC transporter complex. Probably responsible for energy coupling to the transport system (By similarity). (558 aa) |
| | KALB_1462 | Integral membrane protein. (644 aa) |
| | KALB_1435 | Hypothetical protein. (376 aa) |
| | glyS | Glycyl-tRNA synthetase 2. (993 aa) |
| | KALB_1411 | Putative membrane protein. (361 aa) |
| | serS | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (421 aa) |
| | def | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (172 aa) |
| | KALB_1325 | Acyltransferase. (385 aa) |
| | KALB_1323 | Acyltransferase 3. (394 aa) |
| | murI | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (272 aa) |
| | KALB_121 | Hypothetical protein. (253 aa) |
| | KALB_1177 | Abolishes the inhibitory effect of oxytetracycline on protein synthesis by a non-covalent modification of the ribosomes. (640 aa) |
| | ddl | Putative D-alanine--D-lactate ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (344 aa) |
| | murG | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (349 aa) |
| | smpB | SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...] (159 aa) |
| | prfB | Peptide chain release factor 2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. (366 aa) |
| | KALB_1081 | Amidase. (522 aa) |
| | lysS | Lysylphosphatidylglycerol biosynthesis bifunctional protein LysX; Catalyzes the production of L-lysyl-tRNA(Lys)transfer and the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects M.tuberculosis against the CAMPs produced by competiting microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylgl [...] (1113 aa) |
