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| | KALB_2003 | Hypothetical protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (333 aa) |
| | KALB_1008 | Putative adenylyltransferase/sulfurtransferase MoeZ; Catalyzes the conversion of the sulfur carrier protein CysO to CysO-thiocarboxylate. The reaction is thought to proceed in two steps: first, ATP-dependent activation of CysO as acyl- adenylate (CysO-COOAMP), followed by sulfur transfer to give CysO- thiocarboxylate (CysO-COSH) (Probable). The sulfur source is unknown. (386 aa) |
| | KALB_1009 | Aminoglycoside phosphotransferase. (254 aa) |
| | KALB_1080 | Putative glutamine synthetase 2. (447 aa) |
| | KALB_1083 | Glutamine amidotransferase class-I/GMP synthase. (250 aa) |
| | KALB_1090 | Glutamine synthetase 1. (474 aa) |
| | arcA | Arginine deiminase. (417 aa) |
| | KALB_1188 | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein. (331 aa) |
| | KALB_120 | Homogentisate 12-dioxygenase. (395 aa) |
| | KALB_1228 | Asparaginase/glutaminase. (329 aa) |
| | KALB_1229 | Hypothetical protein. (281 aa) |
| | KALB_1231 | Phosphoserine phosphatase. (408 aa) |
| | KALB_1249 | CysO-cysteine peptidase; Protease that hydrolyzes the covalent CysO-cysteine adduct synthesized by CysM to release L-cysteine and regenerate CysO. (151 aa) |
| | KALB_1250 | Hypothetical protein. (92 aa) |
| | KALB_1251 | O-phosphoserine sulfhydrylase; Catalyzes the formation of a covalent CysO-cysteine adduct via a sulfur transfer, using the thiocarboxylated sulfur carrier protein CysO-COSH as sulfur donor and O-phospho-L-serine (OPS) as sulfur acceptor. Can also use sodium sulfide as sulfur donor in vitro, albeit with less efficiency, but not thiosulfate or thio-nitro-benzoate. O-acetylserine (OAS) is a very poor substrate in comparison with OPS. May be of particular importance for cysteine biosynthesis in the persistent phase of M.tuberculosis. (316 aa) |
| | KALB_1276 | Hypothetical protein. (94 aa) |
| | KALB_1320 | Hypothetical protein; Belongs to the methylenetetrahydrofolate reductase family. (117 aa) |
| | KALB_1329 | Hypothetical protein. (393 aa) |
| | KALB_133 | Prephenate dehydratase. (306 aa) |
| | KALB_1332 | Hypothetical protein. (342 aa) |
| | KALB_1346 | Hypothetical protein. (251 aa) |
| | serS | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (421 aa) |
| | KALB_1409 | Phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (326 aa) |
| | KALB_1415 | Glutamine synthetase, type III. (460 aa) |
| | KALB_1416 | Putative glutamine amidotransferase. (245 aa) |
| | KALB_1481 | Putative pyridoxal-dependent decarboxylase, C- sheet domain protein. (412 aa) |
| | KALB_1502 | NAD-specific glutamate dehydrogenase; Involved in arginine catabolism by converting L- glutamate, into 2-oxoglutarate, which is then channeled into the tricarboxylic acid cycle. Can also utilize other amino acids of the glutamate family. (1653 aa) |
| | KALB_1529 | Hypothetical protein. (333 aa) |
| | KALB_1556 | Glutamine synthetase. (471 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (371 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (422 aa) |
| | KALB_1634 | Threonine synthase. (423 aa) |
| | KALB_1812 | Peptidase M20. (415 aa) |
| | KALB_1828 | D-cysteine desulfhydrase; Catalyzes the alpha,beta-elimination reaction of D- cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine (By similarity). (299 aa) |
| | KALB_1867 | Pyridoxal-5'-phosphate-dependent protein subunitbeta. (381 aa) |
| | KALB_1870 | Alanine racemase domain-containing protein. (376 aa) |
| | KALB_1903 | Hypothetical protein. (557 aa) |
| | gcvT | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (367 aa) |
| | KALB_1950 | Branched-chain-amino-acid aminotransferase; Catalyzes the reversible transfers of an amino group from glutamate to the alpha-ketoacid of the respective amino acid in the final step in the biosynthesis of branchedchain amino acids. The amino acids can be ranked in the following order with respect to their efficiency as amino donor: Leu > Ile > Val. (366 aa) |
| | KALB_1962 | Putative asparagine synthetase [glutamine-hydrolyzing]. (642 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (347 aa) |
| | KALB_20 | Anthranilate synthase component 2. (214 aa) |
| | KALB_202 | Phenylalanine and histidine ammonia-lyase. (492 aa) |
| | KALB_2027 | Hypothetical protein. (125 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (743 aa) |
| | KALB_2085 | Aminopeptidase. (227 aa) |
| | KALB_2087 | Glutamate--ammonia ligase; Belongs to the glutamine synthetase family. (434 aa) |
| | KALB_2089 | Amidohydrolase. (412 aa) |
| | KALB_211 | Prephenate dehydrogenase. (325 aa) |
| | KALB_212 | Amidohydrolase. (412 aa) |
| | KALB_2174 | Hypothetical protein. (595 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (140 aa) |
| | glsA | Glutaminase; Belongs to the glutaminase family. (303 aa) |
| | KALB_2316 | Hypothetical protein. (349 aa) |
| | KALB_2322 | Hypothetical protein. (178 aa) |
| | KALB_2331 | Hypothetical protein. (184 aa) |
| | KALB_2508 | Hypothetical protein; Isocitrate/isopropylmalate dehydrogenase. (743 aa) |
| | KALB_2616 | GCN5-related N-acetyltransferase. (308 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (594 aa) |
| | KALB_2645 | Catalyzes the interconversion of ornithine to glutamate semialdehyde (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (412 aa) |
| | KALB_2666 | Alcohol dehydrogenase GroES domain protein. (329 aa) |
| | KALB_269 | Aspartokinase; Belongs to the aspartokinase family. (421 aa) |
| | KALB_270 | Aspartate-semialdehyde dehydrogenase; Belongs to the aspartate-semialdehyde dehydrogenase family. (356 aa) |
| | KALB_2703 | Hypothetical protein. (242 aa) |
| | KALB_2753 | Putative membrane protein. (173 aa) |
| | carA | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (373 aa) |
| | carB | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1100 aa) |
| | KALB_2767 | Acetolactate synthase; Belongs to the TPP enzyme family. (528 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (420 aa) |
| | KALB_2835 | Pyridoxal-dependent decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (444 aa) |
| | KALB_2842 | Benzoylformate decarboxylase; Belongs to the TPP enzyme family. (518 aa) |
| | KALB_2851 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (569 aa) |
| | KALB_2889 | Tryptophanase. (456 aa) |
| | KALB_2933 | Bifunctional deaminase-reductase domain protein. (183 aa) |
| | KALB_2949 | Hypothetical protein. (192 aa) |
| | egtC | Hypothetical protein; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. (255 aa) |
| | egtD | Methyltransferase; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. (323 aa) |
| | KALB_3064 | Amidohydrolase. (348 aa) |
| | KALB_3106 | Hypothetical protein. (335 aa) |
| | KALB_3161 | Hypothetical protein. (201 aa) |
| | KALB_32 | Predicted amino acid aldolase or racemase. (401 aa) |
| | KALB_3202 | Amidohydrolase. (1039 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (482 aa) |
| | KALB_3216 | Proline dehydrogenase. (308 aa) |
| | KALB_323 | Hypothetical protein. (268 aa) |
| | kynA | Tryptophan 23-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (274 aa) |
| | kynU | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (392 aa) |
| | KALB_3364 | 1-aminocyclopropane-1-carboxylate deaminase. (285 aa) |
| | KALB_3430 | Cupin 2 conserved barrel domain protein. (345 aa) |
| | KALB_3529 | Glutamine amidotransferase. (249 aa) |
| | tdh | L-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (343 aa) |
| | KALB_3556 | Amidohydrolase. (235 aa) |
| | KALB_3557 | Hypothetical protein. (134 aa) |
| | KALB_3562 | Hypothetical protein. (318 aa) |
| | KALB_3605 | Asparagine synthase. (612 aa) |
| | KALB_3667 | Hypothetical protein. (397 aa) |
| | gcvH | Hypothetical protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (127 aa) |
| | gcvP | Glycine dehydrogenase [decarboxylating]; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (963 aa) |
| | panD-2 | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (155 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (238 aa) |
| | KALB_3878 | Amidohydrolase. (963 aa) |
| | KALB_3893 | Cyclase family protein. (308 aa) |
| | KALB_3897 | Asparagine synthetase. (599 aa) |
| | KALB_3927 | Hypothetical protein. (318 aa) |
| | KALB_3997 | Hypothetical protein. (254 aa) |
| | KALB_4090 | Hypothetical protein. (249 aa) |
| | KALB_4130 | Hypothetical protein. (358 aa) |
| | KALB_4204 | Hypothetical protein. (180 aa) |
| | KALB_4253 | Hypothetical protein. (443 aa) |
| | KALB_4257 | Hypothetical protein. (196 aa) |
| | KALB_4317 | Hypothetical protein. (428 aa) |
| | KALB_4353 | Hypothetical protein. (162 aa) |
| | KALB_438 | Aspartokinase; Belongs to the aspartokinase family. (420 aa) |
| | KALB_4421 | Hypothetical protein. (347 aa) |
| | KALB_4423 | Hypothetical protein. (470 aa) |
| | KALB_4431 | Hypothetical protein. (266 aa) |
| | ilvE | Hypothetical protein; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (318 aa) |
| | KALB_4449 | Hypothetical protein. (436 aa) |
| | KALB_4585 | Hypothetical protein; Belongs to the TPP enzyme family. (596 aa) |
| | KALB_4684 | Hypothetical protein; Belongs to the TPP enzyme family. (580 aa) |
| | KALB_4720 | Hypothetical protein; Belongs to the group II decarboxylase family. (467 aa) |
| | KALB_4721 | Hypothetical protein. (287 aa) |
| | KALB_4754 | Hypothetical protein. (211 aa) |
| | KALB_4827 | Hypothetical protein. (357 aa) |
| | KALB_491 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (570 aa) |
| | KALB_5013 | Hypothetical protein. (390 aa) |
| | KALB_5103 | Hypothetical protein. (1503 aa) |
| | KALB_5104 | Hypothetical protein. (479 aa) |
| | KALB_5324 | Hypothetical protein. (281 aa) |
| | KALB_5493 | Hypothetical protein. (207 aa) |
| | KALB_5508 | Hypothetical protein. (387 aa) |
| | KALB_5509 | Hypothetical protein. (539 aa) |
| | KALB_5540 | Hypothetical protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (382 aa) |
| | KALB_5549 | Hypothetical protein. (511 aa) |
| | KALB_5658 | Hypothetical protein. (402 aa) |
| | KALB_5662 | Hypothetical protein. (350 aa) |
| | KALB_5685 | Hypothetical protein. (616 aa) |
| | KALB_5692 | Hypothetical protein. (351 aa) |
| | KALB_5717 | Hypothetical protein. (429 aa) |
| | KALB_5723 | Hypothetical protein. (295 aa) |
| | KALB_5725 | Hypothetical protein. (174 aa) |
| | KALB_5740 | Hypothetical protein. (378 aa) |
| | KALB_5746 | Hypothetical protein. (197 aa) |
| | KALB_5795 | Hypothetical protein. (512 aa) |
| | KALB_5801 | Hypothetical protein. (404 aa) |
| | KALB_5848 | Hypothetical protein. (334 aa) |
| | kynA-2 | Hypothetical protein; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (302 aa) |
| | KALB_5968 | Hypothetical protein. (293 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (378 aa) |
| | KALB_6033 | Hypothetical protein; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1205 aa) |
| | KALB_6087 | Hypothetical protein. (244 aa) |
| | KALB_612 | Arginase/agmatinase/formimino glutamase; Belongs to the arginase family. (296 aa) |
| | KALB_6128 | Hypothetical protein. (350 aa) |
| | KALB_6147 | Hypothetical protein. (327 aa) |
| | KALB_6158 | Hypothetical protein. (312 aa) |
| | KALB_619 | Amidohydrolase. (395 aa) |
| | KALB_6226 | Hypothetical protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (403 aa) |
| | KALB_6229 | Hypothetical protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (433 aa) |
| | proA-2 | Hypothetical protein; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (418 aa) |
| | KALB_6340 | Hypothetical protein. (405 aa) |
| | pyrG | Hypothetical protein; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (565 aa) |
| | argH | Hypothetical protein. (470 aa) |
| | argG-2 | Hypothetical protein; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (398 aa) |
| | argR | Hypothetical protein; Regulates arginine biosynthesis genes. (174 aa) |
| | KALB_6451 | Hypothetical protein; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (308 aa) |
| | argD | Hypothetical protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (394 aa) |
| | argB | Hypothetical protein; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (299 aa) |
| | argJ | Hypothetical protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (400 aa) |
| | argC | Hypothetical protein; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (340 aa) |
| | KALB_6486 | Hypothetical protein. (425 aa) |
| | KALB_65 | Hypothetical protein. (257 aa) |
| | KALB_6529 | Hypothetical protein. (200 aa) |
| | pdxT | Hypothetical protein; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (205 aa) |
| | dapF | Hypothetical protein; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (278 aa) |
| | edd | Hypothetical protein; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (615 aa) |
| | KALB_6688 | Hypothetical protein. (339 aa) |
| | KALB_6689 | Hypothetical protein. (367 aa) |
| | folD | Hypothetical protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (273 aa) |
| | KALB_6719 | Hypothetical protein. (332 aa) |
| | KALB_6730 | Hypothetical protein; Belongs to the methylenetetrahydrofolate reductase family. (294 aa) |
| | KALB_6752 | Hypothetical protein. (222 aa) |
| | dtd | Hypothetical protein; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (141 aa) |
| | KALB_6908 | Hypothetical protein. (274 aa) |
| | KALB_6978 | Hypothetical protein. (357 aa) |
| | KALB_7027 | Hypothetical protein. (502 aa) |
| | KALB_7028 | Hypothetical protein. (1523 aa) |
| | trpA | Hypothetical protein; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (262 aa) |
| | trpB | Hypothetical protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (406 aa) |
| | trpC | Hypothetical protein; Belongs to the TrpC family. (269 aa) |
| | trpE | Hypothetical protein; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. (513 aa) |
| | hisA | Hypothetical protein. (245 aa) |
| | hisH | Hypothetical protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (204 aa) |
| | KALB_7109 | Hypothetical protein. (103 aa) |
| | KALB_7110 | Hypothetical protein. (116 aa) |
| | KALB_7163 | Hypothetical protein. (164 aa) |
| | dapB | Hypothetical protein; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (265 aa) |
| | cobB-2 | Hypothetical protein; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (447 aa) |
| | KALB_7242 | Hypothetical protein. (307 aa) |
| | cobQ | Hypothetical protein; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (511 aa) |
| | KALB_7318 | Hypothetical protein. (357 aa) |
| | KALB_7349 | Hypothetical protein. (613 aa) |
| | KALB_7365 | Hypothetical protein; Belongs to the arginase family. (296 aa) |
| | KALB_7393 | Hypothetical protein. (370 aa) |
| | leuD | Hypothetical protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (200 aa) |
| | leuC | Hypothetical protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (467 aa) |
| | KALB_7408 | Hypothetical protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (540 aa) |
| | leuB | Hypothetical protein; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (346 aa) |
| | KALB_7413 | Hypothetical protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (532 aa) |
| | ilvC | Hypothetical protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa) |
| | KALB_7416 | Hypothetical protein. (168 aa) |
| | KALB_7417 | Hypothetical protein. (612 aa) |
| | ilvD | Hypothetical protein; Belongs to the IlvD/Edd family. (614 aa) |
| | KALB_7435 | Hypothetical protein. (236 aa) |
| | KALB_7443 | Hypothetical protein. (345 aa) |
| | KALB_7452 | Hypothetical protein. (300 aa) |
| | thrB | Hypothetical protein; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (295 aa) |
| | KALB_7628 | Hypothetical protein; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (356 aa) |
| | KALB_7629 | Hypothetical protein. (433 aa) |
| | lysA | Hypothetical protein; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (476 aa) |
| | KALB_7661 | Hypothetical protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (321 aa) |
| | KALB_7734 | Hypothetical protein. (607 aa) |
| | mtnC | Hypothetical protein; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. (218 aa) |
| | mtnD | Hypothetical protein; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. (191 aa) |
| | mtnA | Hypothetical protein; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. (518 aa) |
| | metXA | Hypothetical protein; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (372 aa) |
| | KALB_7786 | Hypothetical protein. (435 aa) |
| | KALB_7808 | Hypothetical protein; Belongs to the AlaDH/PNT family. (385 aa) |
| | KALB_7821 | Hypothetical protein. (256 aa) |
| | hutI | Hypothetical protein. (381 aa) |
| | KALB_7844 | Hypothetical protein. (394 aa) |
| | hutU | Hypothetical protein; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (549 aa) |
| | hutH | Hypothetical protein. (515 aa) |
| | KALB_7985 | Hypothetical protein. (430 aa) |
| | KALB_8039 | Hypothetical protein. (373 aa) |
| | folD-2 | Hypothetical protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa) |
| | gcvT-2 | Hypothetical protein; The glycine cleavage system catalyzes the degradation of glycine. (369 aa) |
| | gcvH-2 | Hypothetical protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (128 aa) |
| | glyA-2 | Hypothetical protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (424 aa) |
| | guaA | Hypothetical protein; Catalyzes the synthesis of GMP from XMP. (520 aa) |
| | KALB_8168 | Hypothetical protein; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (366 aa) |
| | glmS | Hypothetical protein; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (613 aa) |
| | KALB_8278 | Hypothetical protein. (291 aa) |
| | KALB_8317 | Hypothetical protein. (349 aa) |
| | KALB_8359 | Hypothetical protein. (311 aa) |
| | KALB_8361 | Hypothetical protein. (324 aa) |
| | proC | Hypothetical protein; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (268 aa) |
| | KALB_8369 | Hypothetical protein. (308 aa) |
| | KALB_840 | Putative cystathionine beta-synthase. (456 aa) |
| | KALB_8410 | Hypothetical protein. (387 aa) |
| | KALB_8415 | Hypothetical protein. (205 aa) |
| | KALB_844 | Cystathionine gamma-synthase. (384 aa) |
| | KALB_8447 | Hypothetical protein. (430 aa) |
| | glmS-2 | Hypothetical protein; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (605 aa) |
| | KALB_846 | Threonine dehydratase. (447 aa) |
| | lysA-2 | Hypothetical protein; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (445 aa) |
| | KALB_8516 | Hypothetical protein. (280 aa) |
| | KALB_8525 | Hypothetical protein. (284 aa) |
| | KALB_8530 | Hypothetical protein; Belongs to the TPP enzyme family. (620 aa) |
| | purF | Hypothetical protein; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (511 aa) |
| | KALB_8550 | Hypothetical protein. (347 aa) |
| | purQ | Hypothetical protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the am [...] (224 aa) |
| | KALB_8693 | Hypothetical protein. (472 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (297 aa) |
| | KALB_939 | Succinyl-diaminopimelate desuccinylase. (383 aa) |
