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| | KALB_1202 | Hypothetical protein; Has an organic peroxide-dependent peroxidase activity. Belongs to the catalase family. (308 aa) |
| | KALB_1214 | Putative propionyl-CoA carboxylase beta chain 6. (477 aa) |
| | KALB_1231 | Phosphoserine phosphatase. (408 aa) |
| | KALB_1369 | AMP-dependent synthetase and ligase. (563 aa) |
| | KALB_1482 | Hypothetical protein. (155 aa) |
| | KALB_149 | ROK family protein. (304 aa) |
| | KALB_1539 | Ribose-5-phosphate isomerase B. (157 aa) |
| | KALB_1850 | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (925 aa) |
| | KALB_1927 | Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family. (383 aa) |
| | KALB_1940 | The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). (582 aa) |
| | KALB_1941 | Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. The pyruvate dehydrogenase complex contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (456 aa) |
| | gcvT | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (367 aa) |
| | KALB_1990 | Glucokinase; Required for glucose repression of many different genes. (325 aa) |
| | pfp | Pyrophosphate--fructose 6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (341 aa) |
| | KALB_1997 | Putative ribose-phosphate pyrophosphokinase. (321 aa) |
| | KALB_2003 | Hypothetical protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (333 aa) |
| | KALB_2098 | Putative 3-hydroxybutyryl-CoA dehydrogenase. (282 aa) |
| | KALB_2166 | Methylmalonate semialdehyde dehydrogenase [acylating] 2; Converts malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively (By similarity). (500 aa) |
| | KALB_2289 | Hypothetical protein. (406 aa) |
| | KALB_2471 | Citrate (Si)-synthase; Belongs to the citrate synthase family. (383 aa) |
| | KALB_2472 | Excisionase family DNA binding domain-containingprotein; Belongs to the citrate synthase family. (403 aa) |
| | KALB_2473 | HpcH/HpaI aldolase; Belongs to the HpcH/HpaI aldolase family. (352 aa) |
| | KALB_2497 | Phosphoglycerate mutase family protein; Fructose-2,6-bisphosphatase. (218 aa) |
| | KALB_2644 | Hypothetical protein. (381 aa) |
| | KALB_2682 | Acetyl-/propionyl-coenzyme A carboxylase alpha chain; This protein carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase (By similarity). (647 aa) |
| | KALB_2700 | Putative serine--pyruvate aminotransferase. (364 aa) |
| | KALB_271 | Carbohydrate kinase FGGY. (481 aa) |
| | KALB_274 | Catalase; Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide; Belongs to the catalase family. (482 aa) |
| | KALB_2780 | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (223 aa) |
| | KALB_2801 | Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (412 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (261 aa) |
| | pgl | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (239 aa) |
| | zwf | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (512 aa) |
| | KALB_2810 | Glucose-6-phosphate isomerase; Belongs to the GPI family. (539 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (371 aa) |
| | KALB_2812 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (699 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (420 aa) |
| | KALB_2840 | Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (368 aa) |
| | KALB_2858 | Methylmalonyl-CoA mutase large subunit; Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthesis. It is unable to catalyze the conversion of isobutyryl-CoA into N-butyryl-CoA. (725 aa) |
| | KALB_2859 | Methylmalonyl-CoA mutase small subunit; Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthesis. It is unable to catalyze the conversion of isobutyryl-CoA into N-butyryl-CoA. (625 aa) |
| | KALB_2962 | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (917 aa) |
| | KALB_3 | Putative 6-phosphogluconate dehydrogenase YqeC; May act as NAD-dependent 6-P-gluconate dehydrogenase. (293 aa) |
| | KALB_3067 | Pyruvate dehydrogenase E1 protein subunit alpha. (365 aa) |
| | KALB_3068 | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). (337 aa) |
| | KALB_3069 | Branched-chain alpha-keto acid dehydrogenase subunit E2. (402 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (656 aa) |
| | KALB_3187 | Succinate dehydrogenase/fumarate reductase iron-sulfur subunit. (243 aa) |
| | KALB_3188 | Succinate dehydrogenase flavoprotein subunit. (645 aa) |
| | KALB_3189 | Succinate dehydrogenase/fumarate reductase cytochrome b subunit. (207 aa) |
| | KALB_3285 | Methylmalonate-semialdehyde dehydrogenase [acylating]. (501 aa) |
| | KALB_3392 | Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family. (370 aa) |
| | KALB_3397 | acetyl-CoA acetyltransferase. (387 aa) |
| | KALB_3416 | Alcohol dehydrogenase GroES domain-containing protein. (361 aa) |
| | KALB_3547 | 3-hydroxybutyryl-CoA dehydrogenase; Catalyzes the NAD-dependent dehydration of beta- hydroxybutyryl-CoA to acetoacetyl-CoA in vitro at pH 10. Also catalyzes the reverse reaction albeit in a lower pH range of 5.5- 6.5. The reverse reaction is able to use NADPH as well as NADH. (287 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (362 aa) |
| | KALB_3637 | Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa) |
| | KALB_3639 | Putative phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity). (745 aa) |
| | gcvH | Hypothetical protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (127 aa) |
| | gcvP | Glycine dehydrogenase [decarboxylating]; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (963 aa) |
| | KALB_3797 | 3-hydroxybutyryl-CoA dehydrogenase; Catalyzes the NAD-dependent dehydration of beta- hydroxybutyryl-CoA to acetoacetyl-CoA in vitro at pH 10. Also catalyzes the reverse reaction albeit in a lower pH range of 5.5- 6.5. The reverse reaction is able to use NADPH as well as NADH. (288 aa) |
| | KALB_3798 | Malate synthase; Belongs to the malate synthase family. (526 aa) |
| | KALB_3799 | Isocitrate lyase; Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway (By similarity). (422 aa) |
| | KALB_3867 | Hypothetical protein. (204 aa) |
| | KALB_4168 | Hypothetical protein. (305 aa) |
| | KALB_4169 | Hypothetical protein. (587 aa) |
| | pdhA | Hypothetical protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (331 aa) |
| | KALB_4171 | Hypothetical protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (330 aa) |
| | KALB_4172 | Hypothetical protein. (432 aa) |
| | KALB_4183 | Hypothetical protein. (598 aa) |
| | KALB_4496 | Hypothetical protein; Belongs to the malate synthase family. (511 aa) |
| | KALB_4545 | Hypothetical protein; Serves to protect cells from the toxic effects of hydrogen peroxide. (682 aa) |
| | KALB_4587 | Hypothetical protein. (611 aa) |
| | tal-2 | Hypothetical protein; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (287 aa) |
| | KALB_5456 | Hypothetical protein. (334 aa) |
| | KALB_549 | NAD-dependent malic enzyme; In addition to the NAD-dependent oxidative decarboxylation of L-malate, the enzyme catalyzes the decarboxylation of oxaloacetate. (462 aa) |
| | KALB_5548 | Hypothetical protein. (374 aa) |
| | KALB_5592 | Hypothetical protein. (555 aa) |
| | fumC | Hypothetical protein; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (492 aa) |
| | KALB_5717 | Hypothetical protein. (429 aa) |
| | KALB_5822 | Hypothetical protein; Belongs to the PEP-utilizing enzyme family. (894 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (378 aa) |
| | KALB_603 | Putative citrate synthase 2; Belongs to the citrate synthase family. (374 aa) |
| | KALB_623 | Citrate synthase 1; Belongs to the citrate synthase family. (413 aa) |
| | KALB_6333 | Hypothetical protein; Belongs to the citrate synthase family. (371 aa) |
| | KALB_6345 | Hypothetical protein; Has an organic peroxide-dependent peroxidase activity. Belongs to the catalase family. (315 aa) |
| | KALB_6381 | Hypothetical protein; Belongs to the thiolase-like superfamily. Thiolase family. (390 aa) |
| | KALB_6485 | Hypothetical protein. (319 aa) |
| | KALB_6552 | Hypothetical protein. (587 aa) |
| | KALB_6680 | Hypothetical protein. (248 aa) |
| | KALB_6681 | Hypothetical protein. (633 aa) |
| | edd | Hypothetical protein; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (615 aa) |
| | KALB_6685 | Hypothetical protein. (206 aa) |
| | KALB_67 | Pyruvate dehydrogenase E1 component. (781 aa) |
| | folD | Hypothetical protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (273 aa) |
| | KALB_6730 | Hypothetical protein; Belongs to the methylenetetrahydrofolate reductase family. (294 aa) |
| | KALB_6847 | Hypothetical protein. (253 aa) |
| | KALB_6863 | Hypothetical protein; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (553 aa) |
| | KALB_7002 | Hypothetical protein; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (480 aa) |
| | KALB_7014 | Hypothetical protein; Belongs to the pyruvate kinase family. (464 aa) |
| | KALB_7055 | Hypothetical protein. (295 aa) |
| | KALB_7056 | Hypothetical protein. (225 aa) |
| | KALB_7242 | Hypothetical protein. (307 aa) |
| | KALB_7366 | Hypothetical protein; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1125 aa) |
| | KALB_7413 | Hypothetical protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (532 aa) |
| | KALB_7452 | Hypothetical protein. (300 aa) |
| | KALB_7546 | Hypothetical protein; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa) |
| | KALB_7547 | Hypothetical protein. (149 aa) |
| | KALB_7555 | Hypothetical protein. (443 aa) |
| | KALB_7566 | Hypothetical protein. (593 aa) |
| | KALB_7597 | Hypothetical protein. (663 aa) |
| | KALB_7732 | Hypothetical protein; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa) |
| | KALB_7733 | Hypothetical protein. (725 aa) |
| | KALB_7772 | Hypothetical protein. (660 aa) |
| | KALB_7802 | Hypothetical protein; Belongs to the iron-sulfur dependent L-serine dehydratase family. (457 aa) |
| | KALB_7853 | Hypothetical protein. (392 aa) |
| | KALB_7868 | Hypothetical protein. (71 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (326 aa) |
| | KALB_7963 | Hypothetical protein. (545 aa) |
| | KALB_7969 | Hypothetical protein. (596 aa) |
| | KALB_8033 | Hypothetical protein. (147 aa) |
| | KALB_8034 | Hypothetical protein. (136 aa) |
| | KALB_8035 | Hypothetical protein. (584 aa) |
| | KALB_8036 | Hypothetical protein. (264 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa) |
| | KALB_8052 | Hypothetical protein; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (407 aa) |
| | mdh | Hypothetical protein; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (328 aa) |
| | folD-2 | Hypothetical protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa) |
| | sucD | Hypothetical protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (296 aa) |
| | sucC | Hypothetical protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (389 aa) |
| | gcvT-2 | Hypothetical protein; The glycine cleavage system catalyzes the degradation of glycine. (369 aa) |
| | gcvH-2 | Hypothetical protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (128 aa) |
| | glyA-2 | Hypothetical protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (424 aa) |
| | KALB_8281 | Hypothetical protein. (627 aa) |
| | KALB_8282 | Hypothetical protein. (353 aa) |
| | KALB_8317 | Hypothetical protein. (349 aa) |
| | gpmA | Hypothetical protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (245 aa) |
| | KALB_838 | 3-ketoacyl-CoA thiolase; Involved in the degradation of long-chain fattyacids; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa) |
| | KALB_8399 | Hypothetical protein. (157 aa) |
| | KALB_846 | Threonine dehydratase. (447 aa) |
| | KALB_8540 | Hypothetical protein. (497 aa) |
| | KALB_8605 | Hypothetical protein; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (343 aa) |
| | KALB_8616 | Hypothetical protein. (309 aa) |
| | KALB_8618 | Hypothetical protein. (278 aa) |
| | KALB_8678 | Hypothetical protein; Belongs to the thiolase-like superfamily. Thiolase family. (427 aa) |
| | KALB_8689 | Hypothetical protein. (447 aa) |
| | KALB_8690 | Hypothetical protein. (339 aa) |
| | KALB_8691 | Hypothetical protein. (398 aa) |
| | KALB_8704 | Hypothetical protein. (301 aa) |
| | fumC-2 | Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (465 aa) |
| | KALB_890 | Fructose-1,6-bisphosphatase class 2; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate. Seems to be the major FBPase of M.tuberculosis and to play a key role in gluconeogenesis for conversion of lipid carbon into cell wall glycans. Does not display activity against inositol 1-phosphate. (353 aa) |
