(96 nodes) Ribosome biogenesis in eukaryotes network (Aspergillus sclerotioniger)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	A0A317VEZ5	RAI1-domain-containing protein. (368 aa)
	A0A317XG14	Utp21-domain-containing protein. (1036 aa)
	A0A317XFR5	Uncharacterized protein. (160 aa)
	A0A317XFH7	RIO1-domain-containing protein. (383 aa)
	A0A317XF04	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (206 aa)
	A0A317XEH1	Kinase-like protein; Belongs to the protein kinase superfamily. (370 aa)
	A0A317XDM2	Pseudouridine synthase. (397 aa)
	A0A317XDD0	Small nucleolar ribonucleo protein complex subunit Utp15. (543 aa)
	A0A317XDB6	Ribonuclease P protein subunit. (247 aa)
	A0A317XD85	GTP-binding nuclear protein; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (198 aa)
	A0A317XCE4	Fcf1-domain-containing protein. (509 aa)
	A0A317XC28	Uncharacterized protein. (918 aa)
	A0A317XC17	SSU processome component Utp10. (1799 aa)
	A0A317XB91	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (347 aa)
	A0A317XB65	Uncharacterized protein. (682 aa)
	A0A317W300	GAR domain-containing protein. (1362 aa)
	A0A317W5G2	Essential for mitotic growth 1. (259 aa)
	A0A317W8B1	Nucleolar protein Nop5. (583 aa)
	A0A317W946	CP-type G domain-containing protein. (540 aa)
	A0A317W9A6	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (267 aa)
	A0A317WA79	Protein kish; Involved in the early part of the secretory pathway. Belongs to the KISH family. (73 aa)
	A0A317WD75	Uncharacterized protein. (530 aa)
	A0A317WGA6	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (654 aa)
	A0A317WGI4	AAA-domain-containing protein. (731 aa)
	A0A317WH10	YggU family protein. (131 aa)
	A0A317WH11	P-loop containing nucleoside triphosphate hydrolase protein. (671 aa)
	A0A317WHE2	RNA exonuclease Rex2. (187 aa)
	A0A317WJ40	WD40 repeat-like protein. (901 aa)
	A0A317WJ44	Ribosome biogenesis protein Nop10. (67 aa)
	A0A317WK64	rRNA pseudouridine synthase. (499 aa)
	TIF6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export; Belongs to the eIF-6 family. (247 aa)
	A0A317WL06	20S-pre-rRNA D-site endonuclease NOB1; Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm. Belongs to the NOB1 family. (411 aa)
	A0A317WL33	Uncharacterized protein. (167 aa)
	A0A317WLQ9	Bromodomain-containing protein. (838 aa)
	A0A317WLZ5	60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. (526 aa)
	A0A317WMN6	RNase3 domain protein. (354 aa)
	A0A317WN63	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation. (177 aa)
	A0A317WN97	Uncharacterized protein. (270 aa)
	A0A317WNH7	Pre-rRNA processing nucleolar protein Sik1. (526 aa)
	A0A317WQC7	Fibrillarin. (320 aa)
	A0A317WSD5	Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (4879 aa)
	A0A317WSS0	NUC189-domain-containing protein. (847 aa)
	A0A317WT11	Putative ribosome biogenesis protein. (1175 aa)
	A0A317WT74	Zn(2)-C6 fungal-type domain-containing protein. (692 aa)
	A0A317WUH5	Uncharacterized protein. (393 aa)
	A0A317WW01	Putative ribonuclease P complex subunit Pop1. (873 aa)
	A0A317WXA7	Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (562 aa)
	A0A317WZC1	Uncharacterized protein. (212 aa)
	A0A317WZE7	Cullin binding protein CanA. (200 aa)
	A0A317X2S0	Kinase-like protein. (351 aa)
	A0A317X2Y5	Exonuclease domain-containing protein. (282 aa)
	A0A317X5G1	RNA-binding domain-containing protein. (738 aa)
	A0A317X6F9	Putative ribosome biogenesis protein Ria1. (1077 aa)
	A0A317X6L5	U3 small nucleolar ribonucleo protein subunit. (188 aa)
	A0A317X6Q0	U3 small nucleolar ribonucleoprotein protein MPP10; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the MPP10 family. (701 aa)
	A0A317X7F0	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (561 aa)
	A0A317X7T4	NTF2-like protein. (161 aa)
	A0A317X822	Putative small nuclear ribonucleo protein complex protein Nhp2. (234 aa)
	A0A317X8E5	Rieske [2Fe-2S] domain protein. (472 aa)
	A0A317X933	DUF4604 domain-containing protein. (165 aa)
	A0A317X956	Uncharacterized protein. (608 aa)
	A0A317X9G4	Uncharacterized protein. (157 aa)
	A0A317X9H7	Brix-domain-containing protein. (297 aa)
	A0A317X9S8	Small nucleolar ribonucleo protein complex subunit. (976 aa)
	A0A317XA31	Uncharacterized protein. (367 aa)
	A0A317XA76	Ribosome biogenesis protein Kri1. (616 aa)
	A0A317XAC6	Utp14-domain-containing protein. (970 aa)
	A0A317XAI8	Shwachman-Bodian-diamond syndrome protein. (360 aa)
	A0A317W1X5	WD40 repeat-like protein. (931 aa)
	A0A317W0V6	Exonuclease. (659 aa)
	A0A317VY48	Small nucleolar ribonucleo protein complex subunit. (957 aa)
	A0A317VUU6	Putative ribosomal small subunit assembly protein. (303 aa)
	A0A317VSM8	RNase III domain-containing protein. (109 aa)
	A0A317VK84	WD domain protein. (962 aa)
	A0A317VJX0	Spindle pole body component. (793 aa)
	A0A317VHN3	Uncharacterized protein. (188 aa)
	A0A317VH16	RNA-3'-phosphate cyclase family protein. (405 aa)
	A0A317VH02	Casein kinase; Belongs to the protein kinase superfamily. (335 aa)
	A0A317VFA7	Uncharacterized protein. (285 aa)
	A0A317VE10	Nucleolus protein required for cell viability. (239 aa)
	NAT10	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1068 aa)
	A0A317VDR7	PHP domain-like protein. (299 aa)
	A0A317V9W9	Exonuclease domain-containing protein. (196 aa)
	A0A317V918	Oxidoreductase; Belongs to the iron/ascorbate-dependent oxidoreductase family. (364 aa)
	A0A317V8M8	Small nucleolar ribonucleo protein complex subunit. (602 aa)
	A0A317V6T8	AAA-domain-containing protein. (751 aa)
	A0A317V5Z7	Uncharacterized protein. (438 aa)
	A0A317V4J2	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (125 aa)
	A0A317V4G9	Uncharacterized protein. (416 aa)
	A0A317V443	Uncharacterized protein. (286 aa)
	A0A317V423	C2H2-type domain-containing protein. (436 aa)
	A0A317V2I0	Uncharacterized protein. (290 aa)
	A0A317V024	DUF1763-domain-containing protein. (140 aa)
	A0A317UX73	Importin N-terminal domain-containing protein. (1072 aa)
	A0A317UVA6	Exonuclease. (703 aa)
	A0A317UV80	U3 small nucleolar RNA-associated protein 22. (1110 aa)

Your Current Organism:

Aspergillus sclerotioniger

NCBI taxonomy Id: 1450535
Other names: A. sclerotioniger CBS 115572, Aspergillus sclerotioniger CBS 115572

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A317UV80	A0A317V4J2	A0A317UV80	A0A317V4J2	U3 small nucleolar RNA-associated protein 22.	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family.	0.976
A0A317UV80	A0A317V8M8	A0A317UV80	A0A317V8M8	U3 small nucleolar RNA-associated protein 22.	Small nucleolar ribonucleo protein complex subunit.	0.997
A0A317UV80	A0A317VE10	A0A317UV80	A0A317VE10	U3 small nucleolar RNA-associated protein 22.	Nucleolus protein required for cell viability.	0.959
A0A317UV80	A0A317VH02	A0A317UV80	A0A317VH02	U3 small nucleolar RNA-associated protein 22.	Casein kinase; Belongs to the protein kinase superfamily.	0.958
A0A317UV80	A0A317VH16	A0A317UV80	A0A317VH16	U3 small nucleolar RNA-associated protein 22.	RNA-3'-phosphate cyclase family protein.	0.992
A0A317UV80	A0A317VK84	A0A317UV80	A0A317VK84	U3 small nucleolar RNA-associated protein 22.	WD domain protein.	0.998
A0A317UV80	A0A317VUU6	A0A317UV80	A0A317VUU6	U3 small nucleolar RNA-associated protein 22.	Putative ribosomal small subunit assembly protein.	0.998
A0A317UV80	A0A317VY48	A0A317UV80	A0A317VY48	U3 small nucleolar RNA-associated protein 22.	Small nucleolar ribonucleo protein complex subunit.	0.998
A0A317UV80	A0A317W1X5	A0A317UV80	A0A317W1X5	U3 small nucleolar RNA-associated protein 22.	WD40 repeat-like protein.	0.998
A0A317UV80	A0A317W5G2	A0A317UV80	A0A317W5G2	U3 small nucleolar RNA-associated protein 22.	Essential for mitotic growth 1.	0.996
A0A317UV80	A0A317W8B1	A0A317UV80	A0A317W8B1	U3 small nucleolar RNA-associated protein 22.	Nucleolar protein Nop5.	0.996
A0A317UV80	A0A317W946	A0A317UV80	A0A317W946	U3 small nucleolar RNA-associated protein 22.	CP-type G domain-containing protein.	0.887
A0A317UV80	A0A317W9A6	A0A317UV80	A0A317W9A6	U3 small nucleolar RNA-associated protein 22.	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family.	0.898
A0A317UV80	A0A317WD75	A0A317UV80	A0A317WD75	U3 small nucleolar RNA-associated protein 22.	Uncharacterized protein.	0.511
A0A317UV80	A0A317WGA6	A0A317UV80	A0A317WGA6	U3 small nucleolar RNA-associated protein 22.	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.	0.812
A0A317UV80	A0A317WGI4	A0A317UV80	A0A317WGI4	U3 small nucleolar RNA-associated protein 22.	AAA-domain-containing protein.	0.445
A0A317UV80	A0A317WH11	A0A317UV80	A0A317WH11	U3 small nucleolar RNA-associated protein 22.	P-loop containing nucleoside triphosphate hydrolase protein.	0.730
A0A317UV80	A0A317WJ40	A0A317UV80	A0A317WJ40	U3 small nucleolar RNA-associated protein 22.	WD40 repeat-like protein.	0.999
A0A317UV80	A0A317WK64	A0A317UV80	A0A317WK64	U3 small nucleolar RNA-associated protein 22.	rRNA pseudouridine synthase.	0.723
A0A317UV80	A0A317WL06	A0A317UV80	A0A317WL06	U3 small nucleolar RNA-associated protein 22.	20S-pre-rRNA D-site endonuclease NOB1; Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm. Belongs to the NOB1 family.	0.896