(20 nodes) DNA polymerase complex, and Lagging strand elongation network (Aspergillus homomorphus)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Your Input:
	A0A395HJ49	DNA_pol_E_B domain-containing protein. (746 aa)
	A0A395HM66	DNA polymerase III subunit. (540 aa)
	A0A395HPH4	DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (500 aa)
	A0A395HQ38	Uncharacterized protein. (356 aa)
	A0A395HQX0	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (870 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (395 aa)
	A0A395HTN5	Chromosome segregation protein. (839 aa)
	A0A395HVJ0	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2218 aa)
	A0A395HW05	DNA polymerase. (1464 aa)
	A0A395HX56	Histone-fold-containing protein. (321 aa)
	A0A395HY07	AAA domain-containing protein. (1086 aa)
	A0A395HY97	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (520 aa)
	A0A395I326	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (653 aa)
	A0A395I4E0	Uncharacterized protein. (425 aa)
	A0A395I4E4	Uncharacterized protein. (447 aa)
	A0A395I6R7	P-loop containing nucleoside triphosphate hydrolase protein. (1163 aa)
	A0A395I6Y7	DNA polymerase. (1106 aa)
	A0A395I866	DNA ligase. (890 aa)
	A0A395IAE2	Uncharacterized protein. (616 aa)
	A0A395IBC5	DNA ligase. (838 aa)

Your Current Organism:

Aspergillus homomorphus

NCBI taxonomy Id: 1450537
Other names: A. homomorphus CBS 101889, Aspergillus homomorphus CBS 101889

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A395HJ49	A0A395HM66	A0A395HJ49	A0A395HM66	DNA_pol_E_B domain-containing protein.	DNA polymerase III subunit.	0.920
A0A395HJ49	A0A395HPH4	A0A395HJ49	A0A395HPH4	DNA_pol_E_B domain-containing protein.	DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family.	0.968
A0A395HJ49	A0A395HQX0	A0A395HJ49	A0A395HQX0	DNA_pol_E_B domain-containing protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.828
A0A395HJ49	A0A395HTN5	A0A395HJ49	A0A395HTN5	DNA_pol_E_B domain-containing protein.	Chromosome segregation protein.	0.992
A0A395HJ49	A0A395HVJ0	A0A395HJ49	A0A395HVJ0	DNA_pol_E_B domain-containing protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.999
A0A395HJ49	A0A395HW05	A0A395HJ49	A0A395HW05	DNA_pol_E_B domain-containing protein.	DNA polymerase.	0.984
A0A395HJ49	A0A395HX56	A0A395HJ49	A0A395HX56	DNA_pol_E_B domain-containing protein.	Histone-fold-containing protein.	0.999
A0A395HJ49	A0A395HY07	A0A395HJ49	A0A395HY07	DNA_pol_E_B domain-containing protein.	AAA domain-containing protein.	0.950
A0A395HJ49	A0A395HY97	A0A395HJ49	A0A395HY97	DNA_pol_E_B domain-containing protein.	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.957
A0A395HJ49	A0A395I326	A0A395HJ49	A0A395I326	DNA_pol_E_B domain-containing protein.	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	0.913
A0A395HJ49	A0A395I4E0	A0A395HJ49	A0A395I4E0	DNA_pol_E_B domain-containing protein.	Uncharacterized protein.	0.655
A0A395HJ49	A0A395I4E4	A0A395HJ49	A0A395I4E4	DNA_pol_E_B domain-containing protein.	Uncharacterized protein.	0.696
A0A395HJ49	A0A395I6R7	A0A395HJ49	A0A395I6R7	DNA_pol_E_B domain-containing protein.	P-loop containing nucleoside triphosphate hydrolase protein.	0.841
A0A395HJ49	A0A395I6Y7	A0A395HJ49	A0A395I6Y7	DNA_pol_E_B domain-containing protein.	DNA polymerase.	0.968
A0A395HJ49	A0A395I866	A0A395HJ49	A0A395I866	DNA_pol_E_B domain-containing protein.	DNA ligase.	0.783
A0A395HJ49	A0A395IAE2	A0A395HJ49	A0A395IAE2	DNA_pol_E_B domain-containing protein.	Uncharacterized protein.	0.820
A0A395HJ49	A0A395IBC5	A0A395HJ49	A0A395IBC5	DNA_pol_E_B domain-containing protein.	DNA ligase.	0.783
A0A395HJ49	FEN1	A0A395HJ49	A0A395HSX7	DNA_pol_E_B domain-containing protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.857
A0A395HM66	A0A395HJ49	A0A395HM66	A0A395HJ49	DNA polymerase III subunit.	DNA_pol_E_B domain-containing protein.	0.920
A0A395HM66	A0A395HPH4	A0A395HM66	A0A395HPH4	DNA polymerase III subunit.	DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family.	0.925