(52 nodes) Negative regulation of gene expression, epigenetic network (Aspergillus homomorphus)

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proteins of unknown 3D structure

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Your Input:
	A0A395HMM6	Putative chromatin remodeling complex subunit. (1469 aa)
	A0A395HHB2	Heat shock protein. (702 aa)
	A0A395HIC0	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (572 aa)
	A0A395HIZ1	tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37; Belongs to the IPP transferase family. (493 aa)
	A0A395HL41	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily. (391 aa)
	A0A395HLF5	zf-C3H1 domain-containing protein. (1264 aa)
	A0A395HLP8	Uncharacterized protein. (221 aa)
	A0A395HLY5	Histone H2A; Belongs to the histone H2A family. (219 aa)
	A0A395HNU2	Rtt106-domain-containing protein. (472 aa)
	A0A395HNW0	RXT2_N domain-containing protein. (540 aa)
	A0A395HQ27	DNA helicase; Belongs to the MCM family. (883 aa)
	A0A395HQ43	Putative DNA helicase ino80. (1702 aa)
	A0A395HQB8	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (324 aa)
	A0A395HR83	P-loop containing nucleoside triphosphate hydrolase protein. (1928 aa)
	A0A395HRN3	RNA-dependent RNA polymerase. (1374 aa)
	A0A395HS95	Stc1 domain-containing protein. (291 aa)
	A0A395HSD5	Uncharacterized protein. (387 aa)
	A0A395HST5	Putative PHD finger domain protein. (600 aa)
	A0A395HSY9	Putative histone acetyltransferase subunit. (252 aa)
	A0A395HT34	Uncharacterized protein. (680 aa)
	A0A395HT68	Histone H2A; Belongs to the histone H2A family. (138 aa)
	A0A395HTG8	Ubiquitin ligase subunit HrtA. (120 aa)
	A0A395HTX7	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (357 aa)
	A0A395HTZ3	Uncharacterized protein. (707 aa)
	A0A395HU31	HRDC domain-containing protein. (791 aa)
	A0A395HUT6	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (785 aa)
	A0A395HV84	Silent information regulator protein Sir2p. (579 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (805 aa)
	A0A395HWK8	Uncharacterized protein. (1123 aa)
	A0A395HZA3	Uncharacterized protein. (1034 aa)
	A0A395HZN3	Uncharacterized protein. (1948 aa)
	A0A395I0J4	Chromo domain-containing protein. (967 aa)
	A0A395I1H2	Putative arsenite resistance protein Ars2. (917 aa)
	A0A395I2R2	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. (514 aa)
	A0A395I2X6	Uncharacterized protein. (499 aa)
	A0A395I4G0	GATA transcription factor. (1167 aa)
	A0A395I5J4	Histone-like transcription factor. (188 aa)
	A0A395I5T2	Putative PHD transcription factor. (903 aa)
	A0A395I6A0	B30.2/SPRY domain-containing protein. (616 aa)
	A0A395I6D0	Uncharacterized protein. (440 aa)
	A0A395I723	P-loop containing nucleoside triphosphate hydrolase protein. (2337 aa)
	A0A395I8T9	Chromo domain-containing protein. (227 aa)
	A0A395I9E4	WD domain protein. (482 aa)
	A0A395I9W0	DNA helicase; Belongs to the MCM family. (720 aa)
	A0A395IA64	Uncharacterized protein. (1174 aa)
	A0A395IC40	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (1093 aa)
	A0A395ICD7	Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family. (513 aa)
	A0A395ICK8	Uncharacterized protein. (380 aa)
	A0A395IDD9	Flavin_Reduct domain-containing protein. (290 aa)
	A0A395IDP3	WD40 repeat-like protein. (791 aa)
	A0A395IDS1	AAA_12 domain-containing protein. (312 aa)
	A0A395IE62	Paf1-domain-containing protein. (506 aa)

Your Current Organism:

Aspergillus homomorphus

NCBI taxonomy Id: 1450537
Other names: A. homomorphus CBS 101889, Aspergillus homomorphus CBS 101889

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A395HHB2	A0A395HU31	A0A395HHB2	A0A395HU31	Heat shock protein.	HRDC domain-containing protein.	0.854
A0A395HHB2	A0A395HUT6	A0A395HHB2	A0A395HUT6	Heat shock protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.794
A0A395HHB2	A0A395I6D0	A0A395HHB2	A0A395I6D0	Heat shock protein.	Uncharacterized protein.	0.446
A0A395HIC0	A0A395HLY5	A0A395HIC0	A0A395HLY5	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	Histone H2A; Belongs to the histone H2A family.	0.945
A0A395HIC0	A0A395HMM6	A0A395HIC0	A0A395HMM6	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	Putative chromatin remodeling complex subunit.	0.526
A0A395HIC0	A0A395HNU2	A0A395HIC0	A0A395HNU2	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	Rtt106-domain-containing protein.	0.594
A0A395HIC0	A0A395HQ27	A0A395HIC0	A0A395HQ27	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	DNA helicase; Belongs to the MCM family.	0.535
A0A395HIC0	A0A395HQ43	A0A395HIC0	A0A395HQ43	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	Putative DNA helicase ino80.	0.485
A0A395HIC0	A0A395HSY9	A0A395HIC0	A0A395HSY9	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	Putative histone acetyltransferase subunit.	0.467
A0A395HIC0	A0A395HT68	A0A395HIC0	A0A395HT68	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	Histone H2A; Belongs to the histone H2A family.	0.647
A0A395HIC0	A0A395I0J4	A0A395HIC0	A0A395I0J4	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	Chromo domain-containing protein.	0.405
A0A395HIC0	A0A395I8T9	A0A395HIC0	A0A395I8T9	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	Chromo domain-containing protein.	0.405
A0A395HIC0	A0A395I9W0	A0A395HIC0	A0A395I9W0	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	DNA helicase; Belongs to the MCM family.	0.692
A0A395HIC0	A0A395IE62	A0A395HIC0	A0A395IE62	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	Paf1-domain-containing protein.	0.992
A0A395HIC0	MCM7	A0A395HIC0	A0A395HVV6	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.699
A0A395HL41	A0A395HT68	A0A395HL41	A0A395HT68	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily.	Histone H2A; Belongs to the histone H2A family.	0.506
A0A395HL41	A0A395HTX7	A0A395HL41	A0A395HTX7	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.484
A0A395HL41	A0A395HU31	A0A395HL41	A0A395HU31	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily.	HRDC domain-containing protein.	0.413
A0A395HL41	A0A395HUT6	A0A395HL41	A0A395HUT6	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.564
A0A395HL41	A0A395HV84	A0A395HL41	A0A395HV84	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily.	Silent information regulator protein Sir2p.	0.878