(46 nodes) RNA polymerase II, holoenzyme network (Aspergillus homomorphus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A395HGP5	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (706 aa)
	A0A395HGZ8	Uncharacterized protein. (495 aa)
	A0A395HHS2	Uncharacterized protein. (379 aa)
	A0A395HIJ6	General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family. (456 aa)
	A0A395HJA0	Uncharacterized protein. (183 aa)
	A0A395HJS3	DNA-directed RNA polymerase I, II, and III subunit Rpb6. (159 aa)
	A0A395HLC1	Uncharacterized protein. (317 aa)
	A0A395HMC6	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (294 aa)
	A0A395HMD0	Bromodomain associated domain protein. (351 aa)
	A0A395HMR2	Acyl_transf_3 domain-containing protein. (469 aa)
	A0A395HMV1	TFIIH basal transcription factor complex, subunit SSL2/RAD25. (821 aa)
	A0A395HNC8	Histone-fold-containing protein. (191 aa)
	A0A395HNW9	Uncharacterized protein. (452 aa)
	A0A395HPX5	Putative DNA repair protein Rex1. (72 aa)
	A0A395HQT6	RNA polymerase II transcription elongation factor. (1221 aa)
	A0A395HRB1	Plus-3-domain-containing protein. (611 aa)
	A0A395HS07	RNA polymerase II Elongator complex associated protein Kti12. (441 aa)
	A0A395HSX3	TFIID-18kDa-domain-containing protein. (337 aa)
	A0A395HUL7	TFIID_20kDa domain-containing protein. (640 aa)
	A0A395HW20	Transcription initiation factor TFIID subunit. (746 aa)
	A0A395HW49	DUF4211 domain-containing protein. (703 aa)
	A0A395HX26	Metallothionein-I gene transcription activator. (81 aa)
	A0A395HZX7	BTP domain-containing protein. (215 aa)
	A0A395I069	WD40 repeat-like protein. (336 aa)
	A0A395I0A3	TAFII55_N domain-containing protein. (499 aa)
	A0A395I1G7	Transcription factor Tfb4. (369 aa)
	A0A395I1K4	Uncharacterized protein. (1270 aa)
	A0A395I1V4	RNA polymerase II transcription factor B subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (479 aa)
	A0A395I2K6	Cyclin-like protein; Belongs to the cyclin family. (429 aa)
	A0A395I2V7	Uncharacterized protein. (287 aa)
	A0A395I4H2	HTH TFE/IIEalpha-type domain-containing protein. (478 aa)
	A0A395I5B4	Uncharacterized protein. (378 aa)
	A0A395I711	Putative serine/threonine protein kinase; Belongs to the protein kinase superfamily. (404 aa)
	A0A395I7R5	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (128 aa)
	A0A395I7U0	CDK-activating kinase assembly factor MAT1. (382 aa)
	A0A395I8M0	Uncharacterized protein. (588 aa)
	A0A395I8Z9	CDC73-domain-containing protein. (514 aa)
	A0A395I9Z8	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (111 aa)
	A0A395IA43	Transcription factor IIA, alpha/beta subunit. (421 aa)
	A0A395IB99	Trimethylguanosine synthase. (1212 aa)
	A0A395IBC3	RNA polymerase II transcription factor subunit 1. (643 aa)
	A0A395IBZ4	Cytochrome P450; Belongs to the cytochrome P450 family. (1173 aa)
	A0A395IE62	Paf1-domain-containing protein. (506 aa)
	A0A395IEQ6	TFIID-31kDa-domain-containing protein. (313 aa)
	A0A395IF47	RNA polymerase II subunit 3. (336 aa)
	A0A395HGU6	Transcription initiation factor TFIID complex subunit. (445 aa)

Your Current Organism:

Aspergillus homomorphus

NCBI taxonomy Id: 1450537
Other names: A. homomorphus CBS 101889, Aspergillus homomorphus CBS 101889

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A395HGP5	A0A395HGU6	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	Transcription initiation factor TFIID complex subunit.	0.888
A0A395HGP5	A0A395HHS2	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	Uncharacterized protein.	0.999
A0A395HGP5	A0A395HIJ6	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family.	0.984
A0A395HGP5	A0A395HJA0	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	Uncharacterized protein.	0.886
A0A395HGP5	A0A395HJS3	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	DNA-directed RNA polymerase I, II, and III subunit Rpb6.	0.985
A0A395HGP5	A0A395HMC6	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	0.993
A0A395HGP5	A0A395HMD0	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	Bromodomain associated domain protein.	0.861
A0A395HGP5	A0A395HMR2	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	Acyl_transf_3 domain-containing protein.	0.886
A0A395HGP5	A0A395HMV1	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	TFIIH basal transcription factor complex, subunit SSL2/RAD25.	0.986
A0A395HGP5	A0A395HNC8	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	Histone-fold-containing protein.	0.886
A0A395HGP5	A0A395HPX5	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	Putative DNA repair protein Rex1.	0.859
A0A395HGP5	A0A395HSX3	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	TFIID-18kDa-domain-containing protein.	0.841
A0A395HGP5	A0A395HUL7	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	TFIID_20kDa domain-containing protein.	0.900
A0A395HGP5	A0A395HW20	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	Transcription initiation factor TFIID subunit.	0.921
A0A395HGP5	A0A395HW49	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	DUF4211 domain-containing protein.	0.841
A0A395HGP5	A0A395HX26	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	Metallothionein-I gene transcription activator.	0.983
A0A395HGP5	A0A395I0A3	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	TAFII55_N domain-containing protein.	0.900
A0A395HGP5	A0A395I1G7	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	Transcription factor Tfb4.	0.985
A0A395HGP5	A0A395I1K4	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	Uncharacterized protein.	0.957
A0A395HGP5	A0A395I1V4	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	RNA polymerase II transcription factor B subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family.	0.990