(45 nodes) RNA polymerase II, holoenzyme network (Aspergillus saccharolyticus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A319A5E2	Putative serine/threonine protein kinase; Belongs to the protein kinase superfamily. (404 aa)
	A0A319A507	RNA polymerase II transcription factor B subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (488 aa)
	A0A319A0M9	Transcription factor TFIIE complex alpha subunit. (461 aa)
	A0A318ZXI9	RNA polymerase II subunit 3. (337 aa)
	A0A318ZUG8	Bromodomain associated protein. (214 aa)
	A0A318ZTM7	WD40 repeat-like protein. (721 aa)
	A0A318ZTI2	Serine/threonine protein kinase chk2; Belongs to the cytochrome P450 family. (1189 aa)
	A0A318ZR28	DNA-directed RNA polymerase I, II, and III subunit Rpb6. (159 aa)
	A0A318ZQ04	Uncharacterized protein. (322 aa)
	A0A318ZN96	RNA polymerase II transcription elongation factor Rtf1p. (611 aa)
	A0A318ZLH0	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (705 aa)
	A0A318ZK35	Uncharacterized protein. (457 aa)
	A0A318ZJL3	Uncharacterized protein. (417 aa)
	A0A318ZJH4	WD40 repeat-like protein. (311 aa)
	A0A318ZIE1	DUF4211 domain-containing protein. (648 aa)
	A0A318ZBY3	TFIID_20kDa domain-containing protein. (627 aa)
	A0A318ZAY4	Transcription factor Tfb4. (390 aa)
	A0A318ZAX4	Transcription initiation factor IID, TAF10 subunit. (287 aa)
	A0A318Z9T1	Trimethylguanosine synthase. (1146 aa)
	A0A318Z8T1	General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family. (456 aa)
	A0A318Z7Z9	RBP11-like subunits of RNA polymerase. (202 aa)
	A0A318Z6I5	TFIIH basal transcription factor complex, subunit SSL2/RAD25. (821 aa)
	A0A318Z6H0	Transcription initiation factor TFIID complex subunit. (445 aa)
	A0A318Z6B4	Cyclin-like protein; Belongs to the cyclin family. (482 aa)
	A0A318Z2Q6	Putative RNA polymerase II transcription elongation factor. (1222 aa)
	A0A318Z2N2	TFIID-18kDa-domain-containing protein. (194 aa)
	A0A318ZC68	Uncharacterized protein. (492 aa)
	A0A318ZCI5	Uncharacterized protein. (378 aa)
	A0A318ZCT5	CDC73-domain-containing protein. (505 aa)
	A0A318ZDK3	Histone-fold-containing protein. (430 aa)
	A0A318ZDR0	TFIID-31kDa-domain-containing protein. (316 aa)
	A0A318ZDS4	Transcription factor IIA, alpha/beta subunit. (402 aa)
	A0A318ZED3	Uncharacterized protein. (589 aa)
	A0A318ZH52	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (294 aa)
	A0A318ZHJ6	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (128 aa)
	A0A318ZI01	RNA polymerase II transcription factor. (641 aa)
	A0A319AQ77	Putative DNA repair protein Rex1. (66 aa)
	A0A319AN51	TAFII55_N domain-containing protein. (501 aa)
	A0A319AH24	DNA-directed RNA polymerases I, II, and III subunit RPABC4. (81 aa)
	A0A319AE73	Paf1-domain-containing protein. (505 aa)
	A0A319AAJ8	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (111 aa)
	A0A319AAE4	Chromatin associated protein KTI12. (452 aa)
	A0A319A6P6	Uncharacterized protein. (1269 aa)
	A0A319A5Q9	Acyl_transf_3 domain-containing protein. (469 aa)
	A0A319A5F4	CDK-activating kinase assembly factor MAT1. (382 aa)

Your Current Organism:

Aspergillus saccharolyticus

NCBI taxonomy Id: 1450539
Other names: A. saccharolyticus JOP 1030-1, Aspergillus saccharolyticus JOP 1030-1

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A318Z2N2	A0A318Z6B4	TFIID-18kDa-domain-containing protein.	Cyclin-like protein; Belongs to the cyclin family.	0.875
A0A318Z2N2	A0A318Z6H0	TFIID-18kDa-domain-containing protein.	Transcription initiation factor TFIID complex subunit.	0.997
A0A318Z2N2	A0A318Z6I5	TFIID-18kDa-domain-containing protein.	TFIIH basal transcription factor complex, subunit SSL2/RAD25.	0.868
A0A318Z2N2	A0A318Z7Z9	TFIID-18kDa-domain-containing protein.	RBP11-like subunits of RNA polymerase.	0.834
A0A318Z2N2	A0A318Z8T1	TFIID-18kDa-domain-containing protein.	General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family.	0.880
A0A318Z2N2	A0A318Z9T1	TFIID-18kDa-domain-containing protein.	Trimethylguanosine synthase.	0.997
A0A318Z2N2	A0A318ZAX4	TFIID-18kDa-domain-containing protein.	Transcription initiation factor IID, TAF10 subunit.	0.997
A0A318Z2N2	A0A318ZAY4	TFIID-18kDa-domain-containing protein.	Transcription factor Tfb4.	0.868
A0A318Z2N2	A0A318ZBY3	TFIID-18kDa-domain-containing protein.	TFIID_20kDa domain-containing protein.	0.998
A0A318Z2N2	A0A318ZCI5	TFIID-18kDa-domain-containing protein.	Uncharacterized protein.	0.872
A0A318Z2N2	A0A318ZDK3	TFIID-18kDa-domain-containing protein.	Histone-fold-containing protein.	0.972
A0A318Z2N2	A0A318ZDR0	TFIID-18kDa-domain-containing protein.	TFIID-31kDa-domain-containing protein.	0.997
A0A318Z2N2	A0A318ZDS4	TFIID-18kDa-domain-containing protein.	Transcription factor IIA, alpha/beta subunit.	0.860
A0A318Z2N2	A0A318ZH52	TFIID-18kDa-domain-containing protein.	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	0.902
A0A318Z2N2	A0A318ZHJ6	TFIID-18kDa-domain-containing protein.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.	0.868
A0A318Z2N2	A0A318ZI01	TFIID-18kDa-domain-containing protein.	RNA polymerase II transcription factor.	0.868
A0A318Z2N2	A0A318ZJL3	TFIID-18kDa-domain-containing protein.	Uncharacterized protein.	0.876
A0A318Z2N2	A0A318ZLH0	TFIID-18kDa-domain-containing protein.	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	0.836
A0A318Z2N2	A0A318ZR28	TFIID-18kDa-domain-containing protein.	DNA-directed RNA polymerase I, II, and III subunit Rpb6.	0.874
A0A318Z2N2	A0A318ZTM7	TFIID-18kDa-domain-containing protein.	WD40 repeat-like protein.	0.997