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dltA-2 dltA-2 dltA dltA ppsE ppsE pksR pksR pksN-2 pksN-2 pksM pksM fabF-2 fabF-2 pksN pksN bioF bioF AJF84864.1 AJF84864.1 serC serC AJF84395.1 AJF84395.1 argD argD metB metB metC metC AJF84618.1 AJF84618.1 AJF84652.1 AJF84652.1 AJF84694.1 AJF84694.1 AJF84102.1 AJF84102.1 hemL hemL AJF84240.1 AJF84240.1 dhbF dhbF thrC thrC sufS sufS AJF86462.1 AJF86462.1 AJF86464.1 AJF86464.1 AJF86488.1 AJF86488.1 alsS alsS pseC pseC glyA glyA AvtA AvtA iolD iolD rocD rocD AJF87105.1 AJF87105.1 AJF87832.1 AJF87832.1 AJF87287.1 AJF87287.1 AJF87321.1 AJF87321.1 dltA-7 dltA-7 srfAC srfAC AJF87472.1 AJF87472.1 gabR gabR gabT gabT AJF87551.1 AJF87551.1 alr-2 alr-2 AJF87630.1 AJF87630.1 AJF87634.1 AJF87634.1 AJF87649.1 AJF87649.1 dat dat AJF84262.1 AJF84262.1 patB patB AJF86225.1 AJF86225.1 AJF86186.1 AJF86186.1 glgP glgP menD menD bioA bioA bioF-2 bioF-2 ilvB ilvB hemL-2 hemL-2 AJF85855.1 AJF85855.1 mccB mccB AJF84824.1 AJF84824.1 dxs dxs AJF85613.1 AJF85613.1 lysA lysA hisC hisC AJF85409.1 AJF85409.1 ilvA ilvA alr alr AJF85326.1 AJF85326.1 sucA sucA AJF87725.1 AJF87725.1 AJF85153.1 AJF85153.1 dltA-4 dltA-4 dltA-3 dltA-3 ppsA ppsA srfAA srfAA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dltA-2Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (2577 aa)
dltAPeptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (3610 aa)
ppsEATP-dependent isoleucine adenylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ATP-dependent AMP-binding enzyme family. (1275 aa)
pksRPolyketide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (2574 aa)
pksN-2Polyketide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (5517 aa)
pksMPolyketide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (4323 aa)
fabF-2Polyketide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (4605 aa)
pksNPolyketide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (5060 aa)
bioF2-amino-3-ketobutyrate CoA ligase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (391 aa)
AJF84864.1Thiamine pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (214 aa)
serCMFS transporter; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (359 aa)
AJF84395.1PLP-dependent transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (134 aa)
argDAcetylornithine aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (385 aa)
metBCatalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology. (373 aa)
metCCatalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology. (390 aa)
AJF84618.1Thiamine-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (204 aa)
AJF84652.1Aminotransferase; Produces methionine from 2-keto-4-methylthiobutyrate and glutamine in vitro; mutations do not affect methionine salvage in vivo however; Derived by automated computational analysis using gene prediction method: Protein Homology. (407 aa)
AJF84694.1Catalyzes the transamination of the aromatic amino acid forming a ketoacid; first step in aromatic amino acid degradation in lactococci; Derived by automated computational analysis using gene prediction method: Protein Homology. (389 aa)
AJF84102.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (220 aa)
hemLGlutamate-1-semialdehyde aminotransferase; Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; Derived by automated computational analysis using gene prediction method: Protein Homology. (429 aa)
AJF84240.1Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (443 aa)
dhbFDiguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (2394 aa)
thrCThreonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (352 aa)
sufSCysteine desulfurase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (406 aa)
AJF86462.1Perosamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DegT/DnrJ/EryC1 family. (417 aa)
AJF86464.1Pyridoxal phosphate-dependent aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DegT/DnrJ/EryC1 family. (376 aa)
AJF86488.1Pyridoxal phosphate-dependent aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DegT/DnrJ/EryC1 family. (390 aa)
alsSCatalyzes the formation of 2-acetolactate from pyruvate in stationary phase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (570 aa)
pseCAminotransferase DegT; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DegT/DnrJ/EryC1 family. (398 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa)
AvtAValine--pyruvate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (434 aa)
iolD3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase; Involved in the cleavage of the C1-C2 bond of 3D-(3,5/4)- trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy-glucuronate (5DG). (637 aa)
rocDOrnithine--oxo-acid aminotransferase; Catalyzes the interconversion of ornithine to glutamate semialdehyde. (401 aa)
AJF87105.1GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (460 aa)
AJF87832.14-amino-4-deoxychorismate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (279 aa)
AJF87287.14-aminobutyrate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (422 aa)
AJF87321.12,4-diaminobutyrate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa)
dltA-7Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (3590 aa)
srfACPeptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1276 aa)
AJF87472.1GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (442 aa)
gabRGntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (470 aa)
gabT4-aminobutyrate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (435 aa)
AJF87551.1Thiamine pyrophosphate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (573 aa)
alr-2Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (389 aa)
AJF87630.1GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (460 aa)
AJF87634.1GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (463 aa)
AJF87649.1GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (482 aa)
datD-alanine aminotransferase; Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha-keto acid in the first half-reaction. (284 aa)
AJF84262.1PLP-dependent transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (76 aa)
patBCystathionine beta-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (387 aa)
AJF86225.1Catalyzes the transamination of the aromatic amino acid forming a ketoacid; first step in aromatic amino acid degradation in lactococci; Derived by automated computational analysis using gene prediction method: Protein Homology. (387 aa)
AJF86186.1Molybdenum cofactor sulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology. (193 aa)
glgPMaltodextrin phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (798 aa)
menD2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily. (579 aa)
bioAAdenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (448 aa)
bioF-28-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (390 aa)
ilvBAcetolactate synthase catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (574 aa)
hemL-2Glutamate-1-semialdehyde aminotransferase; Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate; Derived by automated computational analysis using gene prediction method: Protein Homology. (430 aa)
AJF85855.1Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology. (379 aa)
mccBCatalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology. (379 aa)
AJF84824.1Hypothetical protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (230 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (633 aa)
AJF85613.1Serine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (64 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (439 aa)
hisCHistidinol-phosphate aminotransferase; Catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (360 aa)
AJF85409.1Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (393 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (422 aa)
alrAlanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (393 aa)
AJF85326.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (453 aa)
sucA2-oxoglutarate dehydrogenase; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). (944 aa)
AJF87725.1Pyridoxal-5'-phosphate-dependent protein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (367 aa)
AJF85153.1Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (3980 aa)
dltA-4Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (5363 aa)
dltA-3Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (2602 aa)
ppsAPeptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (2560 aa)
srfAAPeptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (2552 aa)
Your Current Organism:
Bacillus atrophaeus
NCBI taxonomy Id: 1452
Other names: ATCC 49337, B. atrophaeus, Bacillus atriphaeus, Bacillus sp. S2 BC-2, Bacillus subtilis DSM 2277, Bacillus subtilis DSM 675, CCUG 28524, CIP 107159, DSM 7264, IFO 15539, JCM 9070, LMG 16797, LMG:16797, NBRC 15539, NRRL NRS-213
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