STRINGSTRING
phoB phoB AJF84038.1 AJF84038.1 AJF84039.1 AJF84039.1 citS citS citT citT citM citM yfkJ yfkJ mprF mprF AJF87676.1 AJF87676.1 phoA phoA AJF84578.1 AJF84578.1 AJF84620.1 AJF84620.1 kinE kinE kinD kinD AJF84663.1 AJF84663.1 mcpC mcpC kinA kinA AJF84695.1 AJF84695.1 AJF84740.1 AJF84740.1 glsA glsA ctaA ctaA AJF84916.1 AJF84916.1 cheB cheB AJF84926.1 AJF84926.1 AJF84927.1 AJF84927.1 sigD sigD glnA glnA cheY cheY AJF85276.1 AJF85276.1 desK desK AJF85278.1 AJF85278.1 AJF87738.1 AJF87738.1 AJF85324.1 AJF85324.1 atoD atoD AJF85444.1 AJF85444.1 AJF85478.1 AJF85478.1 srrA srrA AJF85592.1 AJF85592.1 AJF85651.1 AJF85651.1 spo0A spo0A pstS pstS spo0B spo0B lrgB lrgB lrgA lrgA AJF85998.1 AJF85998.1 AJF85999.1 AJF85999.1 phoR phoR phoP phoP AJF86026.1 AJF86026.1 AJF86076.1 AJF86076.1 AJF86089.1 AJF86089.1 AJF86124.1 AJF86124.1 AJF86125.1 AJF86125.1 AJF86126.1 AJF86126.1 graR graR AJF86160.1 AJF86160.1 AJF87775.1 AJF87775.1 mcpA mcpA mcpA-2 mcpA-2 mcpA-3 mcpA-3 mcpB mcpB AJF86230.1 AJF86230.1 kapB kapB AJF86236.1 AJF86236.1 AJF86237.1 AJF86237.1 AJF86242.1 AJF86242.1 comA comA AJF86253.1 AJF86253.1 AJF86254.1 AJF86254.1 AJF86370.1 AJF86370.1 cssR cssR cssS cssS AJF86378.1 AJF86378.1 AJF86379.1 AJF86379.1 AJF86380.1 AJF86380.1 AJF86381.1 AJF86381.1 AJF86382.1 AJF86382.1 AJF86383.1 AJF86383.1 AJF86442.1 AJF86442.1 rpoN rpoN sacB sacB AJF86526.1 AJF86526.1 hag hag csrA csrA flgM flgM AJF86598.1 AJF86598.1 degS degS AJF86614.1 AJF86614.1 ywqE ywqE AJF86691.1 AJF86691.1 AJF86748.1 AJF86748.1 spo0F spo0F narI narI narJ narJ narH narH narZ narZ dltA-5 dltA-5 dltB dltB dltC dltC dltD dltD cydB cydB AJF86904.1 AJF86904.1 cimH cimH AJF86988.1 AJF86988.1 AJF86989.1 AJF86989.1 AJF86990.1 AJF86990.1 AJF86991.1 AJF86991.1 AJF87072.1 AJF87072.1 yycG yycG yycF yycF dnaA dnaA agcS-3 agcS-3 glsA-2 glsA-2 AJF87364.1 AJF87364.1 AJF87365.1 AJF87365.1 phoD phoD AJF87463.1 AJF87463.1 AJF87562.1 AJF87562.1 AJF87563.1 AJF87563.1 dctA dctA AJF87620.1 AJF87620.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
phoBAlkaline phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alkaline phosphatase family. (464 aa)
AJF84038.1Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (576 aa)
AJF84039.1Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa)
citSHistidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (528 aa)
citTTranscriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)
citMCitrate transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (432 aa)
yfkJPhosphotyrosine protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (156 aa)
mprFPhosphatidylglycerol lysyltransferase; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms. (855 aa)
AJF87676.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (1177 aa)
phoAAlkaline phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alkaline phosphatase family. (458 aa)
AJF84578.1Serine protease; Derived by automated computational analysis using gene prediction method: Protein Homology. (453 aa)
AJF84620.1Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (453 aa)
kinESporulation kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (739 aa)
kinDSporulation kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (499 aa)
AJF84663.1Flagellar motor protein MotA; With Mot B forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; Derived by automated computational analysis using gene prediction method: Protein Homology. (271 aa)
mcpCChemotaxis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (655 aa)
kinASporulation kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (606 aa)
AJF84695.1Chemotaxis protein CheV; Derived by automated computational analysis using gene prediction method: Protein Homology. (303 aa)
AJF84740.1Sporulation kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (428 aa)
glsAGlutaminase; Catalyzes the formation of glutamate from glutamine; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutaminase family. (309 aa)
ctaAHeme A synthase; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 1 subfamily. (308 aa)
AJF84916.1Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology. (120 aa)
cheBChemotaxis protein CheY; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (355 aa)
AJF84926.1Chemotaxis protein CheA; Derived by automated computational analysis using gene prediction method: Protein Homology. (672 aa)
AJF84927.1Chemotaxis protein CheW; Derived by automated computational analysis using gene prediction method: Protein Homology. (158 aa)
sigDRNA polymerase sigma factor SigD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (254 aa)
glnAGlutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (444 aa)
cheYChemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology. (120 aa)
AJF85276.1Fatty acid desaturase; Derived by automated computational analysis using gene prediction method: Protein Homology. (352 aa)
desKHistidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (378 aa)
AJF85278.1Transcriptional regulatory protein DesR; Derived by automated computational analysis using gene prediction method: Protein Homology. (199 aa)
AJF87738.1Peptidase M15; Derived by automated computational analysis using gene prediction method: Protein Homology. (274 aa)
AJF85324.1CoA-transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (217 aa)
atoDCoA-transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (229 aa)
AJF85444.1Chemotaxis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (256 aa)
AJF85478.1Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (595 aa)
srrATranscriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (240 aa)
AJF85592.1NAD-dependent malic enzyme 1; Derived by automated computational analysis using gene prediction method: Protein Homology. (439 aa)
AJF85651.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
spo0AChemotaxis protein CheY; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. (265 aa)
pstSPhosphate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (300 aa)
spo0BSporulation protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (192 aa)
lrgBAntiholin LrgB; Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses; Belongs to the CidB/LrgB family. LrgB subfamily. (231 aa)
lrgAAntiholin LrgA; Derived by automated computational analysis using gene prediction method: Protein Homology. (145 aa)
AJF85998.1Two-component response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (242 aa)
AJF85999.1Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (593 aa)
phoRAlkaline phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (578 aa)
phoPChemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology. (240 aa)
AJF86026.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (410 aa)
AJF86076.1Flagellar motor protein MotP; Homolog of MotA, appears to be involved in motility on surfaces and under different ionic conditions. With MotS (a MotB homolog) forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; Derived by automated computational analysis using gene prediction method: Protein Homology. (273 aa)
AJF86089.1Malate dehydrogenase; Malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; Derived by automated computational analysis using gene prediction method: Protein Homology. (566 aa)
AJF86124.1Bacitracin ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (646 aa)
AJF86125.1Bacitracin ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (253 aa)
AJF86126.1Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
graRPhoB family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (231 aa)
AJF86160.1Cytochrome D ubiquinol oxidase subunit I; Derived by automated computational analysis using gene prediction method: Protein Homology. (443 aa)
AJF87775.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (346 aa)
mcpAChemotaxis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (662 aa)
mcpA-2Chemotaxis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (660 aa)
mcpA-3Chemotaxis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (661 aa)
mcpBChemotaxis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (662 aa)
AJF86230.1Sporulation kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (429 aa)
kapBKinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (128 aa)
AJF86236.1Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (532 aa)
AJF86237.1Response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration; Derived by automated computational analysis using gene prediction method: Protein Homology. (235 aa)
AJF86242.1Malate permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (446 aa)
comATranscriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (213 aa)
AJF86253.1Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (769 aa)
AJF86254.1ComX pheromone; Derived by automated computational analysis using gene prediction method: Protein Homology. (73 aa)
AJF86370.1Serine protease; Derived by automated computational analysis using gene prediction method: Protein Homology. (455 aa)
cssRTranscriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (225 aa)
cssSHistidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (452 aa)
AJF86378.1LuxR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (211 aa)
AJF86379.1Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (354 aa)
AJF86380.1liaF; Derived by automated computational analysis using gene prediction method: Protein Homology. (243 aa)
AJF86381.1Protein liaG; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
AJF86382.1Protein LiaH; Derived by automated computational analysis using gene prediction method: Protein Homology. (225 aa)
AJF86383.1Protein liaI; Derived by automated computational analysis using gene prediction method: Protein Homology. (126 aa)
AJF86442.1Chemotaxis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (566 aa)
rpoNRNA polymerase sigma54 factor; Derived by automated computational analysis using gene prediction method: Protein Homology. (436 aa)
sacBLevansucrase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glycosyl hydrolase 68 family. (474 aa)
AJF86526.1Bacitracin ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)
hagFlagellin; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (320 aa)
csrACarbon storage regulator CsrA; A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'- UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW. (74 aa)
flgMFlagellar biosynthesis anti-sigma factor FlgM; Derived by automated computational analysis using gene prediction method: Protein Homology. (86 aa)
AJF86598.1Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology. (229 aa)
degSHistidine kinase; Member of the two-component regulatory system DegS/DegU, which plays an important role in the transition growth phase. (387 aa)
AJF86614.1UDP-N-acetylglucosamine 2-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (380 aa)
ywqETyrosine protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (256 aa)
AJF86691.1Nitrogen regulatory PII; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the P(II) protein family. (116 aa)
AJF86748.1Malate dehydrogenase; Malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; Derived by automated computational analysis using gene prediction method: Protein Homology. (565 aa)
spo0FChemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology. (123 aa)
narINitrate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (230 aa)
narJNitrate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (184 aa)
narHNitrate reductase; With NarGJI catalyzes the reduction of nitrate; the beta subunit is an iron sulfur cluster containing electron transfer subunit; one of 3 nitrate reductases in E. coli and in E. coli is expressed when nitrate levels are high; Derived by automated computational analysis using gene prediction method: Protein Homology. (487 aa)
narZNitrate reductase; With NarYV catalyzes the reduction of nitrate; the beta subunit is an iron sulfur cluster containing electron transfer subunit; one of 3 nitrate reductases in E. coli; expression of nitrate reductase Z is not dependent on nitrate levels; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1228 aa)
dltA-5Alanine-phosphoribitol ligase; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent A [...] (503 aa)
dltBAlanine transporter; Could be involved in the transport of activated D-alanine through the membrane. (395 aa)
dltCAlanine-phosphoribitol ligase; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. (78 aa)
dltDAlanine transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (392 aa)
cydBCytochrome d ubiquinol oxidase subunit 2; Derived by automated computational analysis using gene prediction method: Protein Homology. (338 aa)
AJF86904.1Cytochrome D ubiquinol oxidase subunit I; Derived by automated computational analysis using gene prediction method: Protein Homology. (468 aa)
cimHMalate permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (445 aa)
AJF86988.1Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (627 aa)
AJF86989.1Bacitracin ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
AJF86990.1Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
AJF86991.1Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (229 aa)
AJF87072.1Serine protease; Derived by automated computational analysis using gene prediction method: Protein Homology. (398 aa)
yycGHistidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (611 aa)
yycFPhoP family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (235 aa)
dnaAChromosomal replication initiation protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (446 aa)
agcS-3Sodium:alanine symporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa)
glsA-2Glutaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutaminase family. (327 aa)
AJF87364.1Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (430 aa)
AJF87365.1Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (318 aa)
phoDAlkaline phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (583 aa)
AJF87463.1Chemotaxis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (567 aa)
AJF87562.1Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (535 aa)
AJF87563.1Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology. (227 aa)
dctAGlutamate:protein symporter; Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate across the membrane. Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (427 aa)
AJF87620.1Fatty acid desaturase; Derived by automated computational analysis using gene prediction method: Protein Homology. (342 aa)
Your Current Organism:
Bacillus atrophaeus
NCBI taxonomy Id: 1452
Other names: ATCC 49337, B. atrophaeus, Bacillus atriphaeus, Bacillus sp. S2 BC-2, Bacillus subtilis DSM 2277, Bacillus subtilis DSM 675, CCUG 28524, CIP 107159, DSM 7264, IFO 15539, JCM 9070, LMG 16797, LMG:16797, NBRC 15539, NRRL NRS-213
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