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NMS_0049 NMS_0049 NMS_0069 NMS_0069 NMS_0111 NMS_0111 NMS_0112 NMS_0112 NMS_0117 NMS_0117 NMS_0128 NMS_0128 NMS_0205 NMS_0205 eno eno NMS_0275 NMS_0275 NMS_0441 NMS_0441 fbp fbp NMS_0496 NMS_0496 NMS_0497 NMS_0497 NMS_0498 NMS_0498 NMS_0542 NMS_0542 pgi pgi NMS_0563 NMS_0563 NMS_0592 NMS_0592 NMS_0622 NMS_0622 NMS_0759 NMS_0759 NMS_0762 NMS_0762 NMS_0763 NMS_0763 NMS_0806 NMS_0806 NMS_0817 NMS_0817 NMS_0830 NMS_0830 pgk pgk NMS_0857 NMS_0857 NMS_0877 NMS_0877 NMS_0879 NMS_0879 NMS_0880 NMS_0880 NMS_0979 NMS_0979 NMS_1092 NMS_1092 NMS_1093 NMS_1093 NMS_1130 NMS_1130 gcvH gcvH pckA pckA NMS_1158 NMS_1158 NMS_1159 NMS_1159 NMS_1254 NMS_1254 NMS_1291 NMS_1291 NMS_1302 NMS_1302 NMS_1351 NMS_1351 pdhA pdhA NMS_1451 NMS_1451 NMS_1467 NMS_1467 NMS_1486 NMS_1486 NMS_1498 NMS_1498 mdh mdh NMS_1585 NMS_1585 NMS_1608 NMS_1608 NMS_1611 NMS_1611 NMS_1613 NMS_1613 NMS_1615 NMS_1615 NMS_1616 NMS_1616 NMS_1617 NMS_1617 NMS_1618 NMS_1618 NMS_1619 NMS_1619 NMS_1622 NMS_1622 NMS_1623 NMS_1623 NMS_1625 NMS_1625 NMS_1637 NMS_1637 NMS_1640 NMS_1640 NMS_1644 NMS_1644 NMS_1645 NMS_1645 tpiA tpiA NMS_1757 NMS_1757 NMS_1800 NMS_1800 tal tal NMS_1884 NMS_1884 NMS_1927 NMS_1927 ackA ackA NMS_1973 NMS_1973 NMS_2006 NMS_2006 NMS_2013 NMS_2013 NMS_2025 NMS_2025 NMS_2154 NMS_2154 NMS_2170 NMS_2170 pfkA pfkA NMS_2191 NMS_2191 sucC sucC sucD sucD NMS_2308 NMS_2308 NMS_2317 NMS_2317 fumC fumC NMS_2397 NMS_2397 NMS_2483 NMS_2483 NMS_2484 NMS_2484 NMS_2600 NMS_2600 NMS_2615 NMS_2615 NMS_2616 NMS_2616 NMS_2618 NMS_2618 icmF icmF NMS_2665 NMS_2665 gcvT gcvT NMS_2755 NMS_2755 glyA glyA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NMS_0049Isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (739 aa)
NMS_0069Ferredoxin reductase. (201 aa)
NMS_0111Transketolase, N-terminal section. (340 aa)
NMS_0112Transketolase, C-terminal section. (318 aa)
NMS_0117Transcriptional regulator, MerR family. (305 aa)
NMS_0128Aconitate hydratase. (755 aa)
NMS_0205Citrate synthase; Belongs to the citrate synthase family. (428 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa)
NMS_0275NAD-dependent glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (331 aa)
NMS_0441Ribose-phosphate pyrophosphokinase. (313 aa)
fbpFructose-1,6-bisphosphatase, type I; Belongs to the FBPase class 1 family. (336 aa)
NMS_0496Electron transfer flavoprotein, alpha subunit. (322 aa)
NMS_0497Electron transfer flavoprotein, beta subunit. (248 aa)
NMS_0498Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (326 aa)
NMS_0542glutaryl-CoA dehydrogenase. (392 aa)
pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (545 aa)
NMS_0563Similar to glutathione reductase. (445 aa)
NMS_0592Pyruvate kinase; Belongs to the pyruvate kinase family. (477 aa)
NMS_0622Aldehyde dehydrogenase B; Belongs to the aldehyde dehydrogenase family. (517 aa)
NMS_07593-ketoacid-coenzyme A transferase subunit B. (217 aa)
NMS_07623-ketoacid-coenzyme A transferase subunit A. (233 aa)
NMS_0763Flavodoxin reductases (ferredoxin-NADPH reductases) family 1. (346 aa)
NMS_0806Lactoylglutathione lyase and related lyases. (135 aa)
NMS_0817Ribose 5-phosphate isomerase B. (143 aa)
NMS_0830Alkane-1 monooxygenase. (351 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (394 aa)
NMS_0857Capsular polysaccharide biosynthesis protein. (433 aa)
NMS_0877Succinate dehydrogenase iron-sulfur protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (248 aa)
NMS_0879Succinate dehydrogenase flavoprotein subunit. (667 aa)
NMS_0880Succinate dehydrogenase cytochrome b subunit. (223 aa)
NMS_0979enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (255 aa)
NMS_10922-oxoglutarate dehydrogenase E1 component. (918 aa)
NMS_1093Dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (444 aa)
NMS_1130NADP-dependent malic enzyme. (770 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (535 aa)
NMS_1158Succinate-semialdehyde dehydrogenase. (461 aa)
NMS_1159glutaryl-CoA dehydrogenase. (454 aa)
NMS_1254Dihydrolipoamide dehydrogenase of 2-oxoglutarate dehydrogenase. (467 aa)
NMS_1291Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (219 aa)
NMS_1302Fructose-bisphosphate aldolase class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (355 aa)
NMS_1351butyryl-CoA dehydrogenase. (380 aa)
pdhAPyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (332 aa)
NMS_1451Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (564 aa)
NMS_1467butyryl-CoA dehydrogenase. (389 aa)
NMS_1486Mannose-6-phosphate isomerase. (323 aa)
NMS_1498Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex. (451 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (306 aa)
NMS_1585Hypothetical protein. (233 aa)
NMS_1608Dihydrolipoamide dehydrogenase of branched-chain alpha-keto acid dehydrogenase. (463 aa)
NMS_1611hydroxymethylglutaryl-CoA lyase. (295 aa)
NMS_1613phenylacetate-CoA oxygenase/reductase, PaaK subunit. (358 aa)
NMS_1615phenylacetate-CoA oxygenase, PaaG subunit. (320 aa)
NMS_1616phenylacetate-CoA oxygenase, PaaH subunit. (62 aa)
NMS_1617phenylacetate-CoA oxygenase, PaaI subunit. (273 aa)
NMS_1618phenylacetate-CoA oxygenase, PaaJ subunit. (165 aa)
NMS_1619enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (259 aa)
NMS_16223-hydroxybutyryl-CoA dehydrogenase. (404 aa)
NMS_1623Phenylacetic acid degradation protein PaaD, thioesterase. (135 aa)
NMS_16253-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
NMS_1637Phenylacetic acid degradation protein PaaN, ring-opening aldehyde dehydrogenase. (825 aa)
NMS_1640methylglutaconyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (250 aa)
NMS_1644Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex. (456 aa)
NMS_1645Branched-chain alpha-keto acid dehydrogenase, E1 component, alpha subunit. (692 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (250 aa)
NMS_1757Putative periplasmic protein kinase ArgK and related GTPases of G3E family. (336 aa)
NMS_1800methylcrotonyl-CoA carboxylase carboxyl transferase subunit. (542 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (218 aa)
NMS_1884Branched-chain alpha-keto acid dehydrogenase, E1 component, alpha subunit. (804 aa)
NMS_1927Glycine dehydrogenase; Belongs to the GcvP family. (945 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (394 aa)
NMS_1973Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (699 aa)
NMS_2006Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (635 aa)
NMS_2013NAD-dependent glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (482 aa)
NMS_20253-hydroxybutyryl-CoA dehydrogenase. (296 aa)
NMS_2154Succinate-semialdehyde dehydrogenase. (452 aa)
NMS_2170Glucose-1-phosphate thymidylyltransferase. (390 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (327 aa)
NMS_2191NAD-dependent glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
sucCsuccinyl-CoA ligase [ADP-forming] beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (397 aa)
sucDsuccinyl-CoA ligase [ADP-forming] alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
NMS_2308Branched-chain alpha-keto acid dehydrogenase, E1 component, alpha subunit. (659 aa)
NMS_2317Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (853 aa)
fumCFumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (464 aa)
NMS_2397L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (481 aa)
NMS_2483methylmalonyl-CoA mutase, small subunit. (465 aa)
NMS_2484methylmalonyl-CoA mutase. (713 aa)
NMS_2600Phosphoglucomutase. (571 aa)
NMS_2615enoyl-CoA hydratase. (802 aa)
NMS_26163-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
NMS_2618butyryl-CoA dehydrogenase. (602 aa)
icmFB12 binding domain / kinase domain / Methylmalonyl-CoA mutase; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. (1175 aa)
NMS_2665acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
gcvTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (363 aa)
NMS_2755Dihydrolipoamide dehydrogenase of 2-oxoglutarate dehydrogenase. (466 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (425 aa)
Your Current Organism:
Nonlabens marinus
NCBI taxonomy Id: 1454201
Other names: Flavobacteria bacterium S1-08, N. marinus S1-08, Nonlabens marinus S1-08
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