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NMS_0049 NMS_0049 NMS_0128 NMS_0128 NMS_0205 NMS_0205 NMS_0498 NMS_0498 NMS_0563 NMS_0563 NMS_0622 NMS_0622 NMS_0877 NMS_0877 NMS_0879 NMS_0879 NMS_0880 NMS_0880 NMS_1092 NMS_1092 NMS_1093 NMS_1093 NMS_1130 NMS_1130 gcvH gcvH pckA pckA NMS_1158 NMS_1158 NMS_1254 NMS_1254 pdhA pdhA NMS_1451 NMS_1451 NMS_1498 NMS_1498 mdh mdh NMS_1608 NMS_1608 NMS_1644 NMS_1644 NMS_1645 NMS_1645 NMS_1884 NMS_1884 NMS_1927 NMS_1927 ackA ackA NMS_1973 NMS_1973 NMS_2006 NMS_2006 NMS_2154 NMS_2154 sucC sucC sucD sucD NMS_2308 NMS_2308 NMS_2317 NMS_2317 fumC fumC NMS_2397 NMS_2397 gcvT gcvT NMS_2755 NMS_2755 glyA glyA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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NMS_0049Isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (739 aa)
NMS_0128Aconitate hydratase. (755 aa)
NMS_0205Citrate synthase; Belongs to the citrate synthase family. (428 aa)
NMS_0498Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (326 aa)
NMS_0563Similar to glutathione reductase. (445 aa)
NMS_0622Aldehyde dehydrogenase B; Belongs to the aldehyde dehydrogenase family. (517 aa)
NMS_0877Succinate dehydrogenase iron-sulfur protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (248 aa)
NMS_0879Succinate dehydrogenase flavoprotein subunit. (667 aa)
NMS_0880Succinate dehydrogenase cytochrome b subunit. (223 aa)
NMS_10922-oxoglutarate dehydrogenase E1 component. (918 aa)
NMS_1093Dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (444 aa)
NMS_1130NADP-dependent malic enzyme. (770 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (535 aa)
NMS_1158Succinate-semialdehyde dehydrogenase. (461 aa)
NMS_1254Dihydrolipoamide dehydrogenase of 2-oxoglutarate dehydrogenase. (467 aa)
pdhAPyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (332 aa)
NMS_1451Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (564 aa)
NMS_1498Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex. (451 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (306 aa)
NMS_1608Dihydrolipoamide dehydrogenase of branched-chain alpha-keto acid dehydrogenase. (463 aa)
NMS_1644Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex. (456 aa)
NMS_1645Branched-chain alpha-keto acid dehydrogenase, E1 component, alpha subunit. (692 aa)
NMS_1884Branched-chain alpha-keto acid dehydrogenase, E1 component, alpha subunit. (804 aa)
NMS_1927Glycine dehydrogenase; Belongs to the GcvP family. (945 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (394 aa)
NMS_1973Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (699 aa)
NMS_2006Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (635 aa)
NMS_2154Succinate-semialdehyde dehydrogenase. (452 aa)
sucCsuccinyl-CoA ligase [ADP-forming] beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (397 aa)
sucDsuccinyl-CoA ligase [ADP-forming] alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
NMS_2308Branched-chain alpha-keto acid dehydrogenase, E1 component, alpha subunit. (659 aa)
NMS_2317Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (853 aa)
fumCFumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (464 aa)
NMS_2397L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (481 aa)
gcvTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (363 aa)
NMS_2755Dihydrolipoamide dehydrogenase of 2-oxoglutarate dehydrogenase. (466 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (425 aa)
Your Current Organism:
Nonlabens marinus
NCBI taxonomy Id: 1454201
Other names: Flavobacteria bacterium S1-08, N. marinus S1-08, Nonlabens marinus S1-08
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